@article{RN214,
   author = {Neal, R. E., 2nd and Garcia, P. A. and Robertson, J. L. and Davalos, R. V.},
   title = {Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning},
   journal = {IEEE Trans Biomed Eng},
   volume = {59},
   number = {4},
   pages = {1076-85},
   note = {1558-2531
Neal, Robert E 2nd
Garcia, Paulo A
Robertson, John L
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
United States
2012/01/11
IEEE Trans Biomed Eng. 2012 Apr;59(4):1076-85. doi: 10.1109/TBME.2012.2182994. Epub 2012 Jan 6.},
   abstract = {Irreversible electroporation is a new technique to kill cells in targeted tissue, such as tumors, through a nonthermal mechanism using electric pulses to irrecoverably disrupt the cell membrane. Treatment effects relate to the tissue electric field distribution, which can be predicted with numerical modeling for therapy planning. Pulse effects will change the cell and tissue properties through thermal and electroporation (EP)-based processes. This investigation characterizes these changes by measuring the electrical conductivity and temperature of ex vivo renal porcine tissue within a single pulse and for a 200 pulse protocol. These changes are incorporated into an equivalent circuit model for cells and tissue with a variable EP-based resistance, providing a potential method to estimate conductivity as a function of electric field and pulse length for other tissues. Finally, a numerical model using a human kidney volumetric mesh evaluated how treatment predictions vary when EP- and temperature-based electrical conductivity changes are incorporated. We conclude that significant changes in predicted outcomes will occur when the experimental results are applied to the numerical model, where the direction and degree of change varies with the electric field considered.},
   keywords = {Animals
Cell Membrane Permeability/*physiology/*radiation effects
Computer Simulation
Dose-Response Relationship, Radiation
Electric Conductivity
Electromagnetic Fields
Electroporation/*methods
Kidney/*physiology/*radiation effects
*Models, Biological
Radiation Dosage
Swine},
   ISSN = {0018-9294},
   DOI = {10.1109/tbme.2012.2182994},
   year = {2012},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Robertson"],"firstnames":["J.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning","journal":"IEEE Trans Biomed Eng","volume":"59","number":"4","pages":"1076-85","note":"1558-2531 Neal, Robert E 2nd Garcia, Paulo A Robertson, John L Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States 2012/01/11 IEEE Trans Biomed Eng. 2012 Apr;59(4):1076-85. doi: 10.1109/TBME.2012.2182994. Epub 2012 Jan 6.","abstract":"Irreversible electroporation is a new technique to kill cells in targeted tissue, such as tumors, through a nonthermal mechanism using electric pulses to irrecoverably disrupt the cell membrane. Treatment effects relate to the tissue electric field distribution, which can be predicted with numerical modeling for therapy planning. Pulse effects will change the cell and tissue properties through thermal and electroporation (EP)-based processes. This investigation characterizes these changes by measuring the electrical conductivity and temperature of ex vivo renal porcine tissue within a single pulse and for a 200 pulse protocol. These changes are incorporated into an equivalent circuit model for cells and tissue with a variable EP-based resistance, providing a potential method to estimate conductivity as a function of electric field and pulse length for other tissues. Finally, a numerical model using a human kidney volumetric mesh evaluated how treatment predictions vary when EP- and temperature-based electrical conductivity changes are incorporated. We conclude that significant changes in predicted outcomes will occur when the experimental results are applied to the numerical model, where the direction and degree of change varies with the electric field considered.","keywords":"Animals Cell Membrane Permeability/*physiology/*radiation effects Computer Simulation Dose-Response Relationship, Radiation Electric Conductivity Electromagnetic Fields Electroporation/*methods Kidney/*physiology/*radiation effects *Models, Biological Radiation Dosage Swine","issn":"0018-9294","doi":"10.1109/tbme.2012.2182994","year":"2012","bibtex":"@article{RN214,\n author = {Neal, R. E., 2nd and Garcia, P. A. and Robertson, J. L. and Davalos, R. V.},\n title = {Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning},\n journal = {IEEE Trans Biomed Eng},\n volume = {59},\n number = {4},\n pages = {1076-85},\n note = {1558-2531\nNeal, Robert E 2nd\nGarcia, Paulo A\nRobertson, John L\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nResearch Support, U.S. Gov't, Non-P.H.S.\nUnited States\n2012/01/11\nIEEE Trans Biomed Eng. 2012 Apr;59(4):1076-85. doi: 10.1109/TBME.2012.2182994. Epub 2012 Jan 6.},\n abstract = {Irreversible electroporation is a new technique to kill cells in targeted tissue, such as tumors, through a nonthermal mechanism using electric pulses to irrecoverably disrupt the cell membrane. Treatment effects relate to the tissue electric field distribution, which can be predicted with numerical modeling for therapy planning. Pulse effects will change the cell and tissue properties through thermal and electroporation (EP)-based processes. This investigation characterizes these changes by measuring the electrical conductivity and temperature of ex vivo renal porcine tissue within a single pulse and for a 200 pulse protocol. These changes are incorporated into an equivalent circuit model for cells and tissue with a variable EP-based resistance, providing a potential method to estimate conductivity as a function of electric field and pulse length for other tissues. Finally, a numerical model using a human kidney volumetric mesh evaluated how treatment predictions vary when EP- and temperature-based electrical conductivity changes are incorporated. 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V."],"key":"RN214","id":"RN214","bibbaseid":"neal-garcia-robertson-davalos-experimentalcharacterizationandnumericalmodelingoftissueelectricalconductivityduringpulsedelectricfieldsforirreversibleelectroporationtreatmentplanning-2012","role":"author","urls":{},"keyword":["Animals Cell Membrane Permeability/*physiology/*radiation effects Computer Simulation Dose-Response Relationship","Radiation Electric Conductivity Electromagnetic Fields Electroporation/*methods Kidney/*physiology/*radiation effects *Models","Biological Radiation Dosage Swine"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["animals cell membrane permeability/*physiology/*radiation effects computer simulation dose-response relationship","radiation electric conductivity electromagnetic fields electroporation/*methods kidney/*physiology/*radiation effects *models","biological radiation dosage swine"],"search_terms":["experimental","characterization","numerical","modeling","tissue","electrical","conductivity","during","pulsed","electric","fields","irreversible","electroporation","treatment","planning","neal","garcia","robertson","davalos"],"title":"Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning","year":2012}