@article{RN212,
   author = {Neal, R. E., 2nd and Garcia, P. A. and Robertson, J. L. and Davalos, R. V.},
   title = {Experimental characterization of intrapulse tissue conductivity changes for electroporation},
   journal = {Annu Int Conf IEEE Eng Med Biol Soc},
   volume = {2011},
   pages = {5581-4},
   note = {2694-0604
Neal, Robert E 2nd
Garcia, Paulo A
Robertson, John L
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
United States
2012/01/19
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:5581-4. doi: 10.1109/IEMBS.2011.6091350.},
   abstract = {Cells exposed to short electric pulses experience a change in their transmembrane potential, which can lead to increased membrane permeability of the cell. When the energy of the pulses surpasses a threshold, the cell dies in a non-thermal manner known as irreversible electroporation (IRE). IRE has shown promise in the focal ablation of pathologic tissues. Its non-thermal mechanism spares sensitive structures and facilitates rapid lesion resolution. IRE effects depend on the electric field distribution, which can be predicted with numerical modeling. When the cells become permeabilized, the bulk tissue properties change, affecting this distribution. For IRE to become a reliable and successful treatment of diseased tissues, robust predictive treatment planning methods must be developed. It is vital to understand the changes in tissue properties undergoing the electric pulses to improve numerical models and predict treatment volumes. We report on the experimental characterization of these changes for kidney tissue. Tissue samples were pulsed between plate electrodes while intrapulse voltage and current data were measured to determine the conductivity of the tissue during the pulse. Conductivity was then established as a function of the electric field to which the tissue is exposed. This conductivity curve was used in a numerical model to demonstrate the impact of accounting for these changes when modeling electric field distributions to develop treatment plans.},
   keywords = {Animals
Computer Simulation
Dose-Response Relationship, Radiation
Electric Conductivity
Electromagnetic Fields
Electroporation/*methods
In Vitro Techniques
Kidney Medulla/*physiology/*radiation effects
*Models, Biological
Radiation Dosage
Swine},
   ISSN = {2375-7477},
   DOI = {10.1109/iembs.2011.6091350},
   year = {2011},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Robertson"],"firstnames":["J.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Experimental characterization of intrapulse tissue conductivity changes for electroporation","journal":"Annu Int Conf IEEE Eng Med Biol Soc","volume":"2011","pages":"5581-4","note":"2694-0604 Neal, Robert E 2nd Garcia, Paulo A Robertson, John L Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't United States 2012/01/19 Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:5581-4. doi: 10.1109/IEMBS.2011.6091350.","abstract":"Cells exposed to short electric pulses experience a change in their transmembrane potential, which can lead to increased membrane permeability of the cell. When the energy of the pulses surpasses a threshold, the cell dies in a non-thermal manner known as irreversible electroporation (IRE). IRE has shown promise in the focal ablation of pathologic tissues. Its non-thermal mechanism spares sensitive structures and facilitates rapid lesion resolution. IRE effects depend on the electric field distribution, which can be predicted with numerical modeling. When the cells become permeabilized, the bulk tissue properties change, affecting this distribution. For IRE to become a reliable and successful treatment of diseased tissues, robust predictive treatment planning methods must be developed. It is vital to understand the changes in tissue properties undergoing the electric pulses to improve numerical models and predict treatment volumes. We report on the experimental characterization of these changes for kidney tissue. Tissue samples were pulsed between plate electrodes while intrapulse voltage and current data were measured to determine the conductivity of the tissue during the pulse. Conductivity was then established as a function of the electric field to which the tissue is exposed. This conductivity curve was used in a numerical model to demonstrate the impact of accounting for these changes when modeling electric field distributions to develop treatment plans.","keywords":"Animals Computer Simulation Dose-Response Relationship, Radiation Electric Conductivity Electromagnetic Fields Electroporation/*methods In Vitro Techniques Kidney Medulla/*physiology/*radiation effects *Models, Biological Radiation Dosage Swine","issn":"2375-7477","doi":"10.1109/iembs.2011.6091350","year":"2011","bibtex":"@article{RN212,\n author = {Neal, R. E., 2nd and Garcia, P. A. and Robertson, J. L. and Davalos, R. V.},\n title = {Experimental characterization of intrapulse tissue conductivity changes for electroporation},\n journal = {Annu Int Conf IEEE Eng Med Biol Soc},\n volume = {2011},\n pages = {5581-4},\n note = {2694-0604\nNeal, Robert E 2nd\nGarcia, Paulo A\nRobertson, John L\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nUnited States\n2012/01/19\nAnnu Int Conf IEEE Eng Med Biol Soc. 2011;2011:5581-4. doi: 10.1109/IEMBS.2011.6091350.},\n abstract = {Cells exposed to short electric pulses experience a change in their transmembrane potential, which can lead to increased membrane permeability of the cell. When the energy of the pulses surpasses a threshold, the cell dies in a non-thermal manner known as irreversible electroporation (IRE). IRE has shown promise in the focal ablation of pathologic tissues. Its non-thermal mechanism spares sensitive structures and facilitates rapid lesion resolution. IRE effects depend on the electric field distribution, which can be predicted with numerical modeling. When the cells become permeabilized, the bulk tissue properties change, affecting this distribution. For IRE to become a reliable and successful treatment of diseased tissues, robust predictive treatment planning methods must be developed. It is vital to understand the changes in tissue properties undergoing the electric pulses to improve numerical models and predict treatment volumes. We report on the experimental characterization of these changes for kidney tissue. Tissue samples were pulsed between plate electrodes while intrapulse voltage and current data were measured to determine the conductivity of the tissue during the pulse. Conductivity was then established as a function of the electric field to which the tissue is exposed. This conductivity curve was used in a numerical model to demonstrate the impact of accounting for these changes when modeling electric field distributions to develop treatment plans.},\n keywords = {Animals\nComputer Simulation\nDose-Response Relationship, Radiation\nElectric Conductivity\nElectromagnetic Fields\nElectroporation/*methods\nIn Vitro Techniques\nKidney Medulla/*physiology/*radiation effects\n*Models, Biological\nRadiation Dosage\nSwine},\n ISSN = {2375-7477},\n DOI = {10.1109/iembs.2011.6091350},\n year = {2011},\n type = {Journal Article}\n}\n\n","author_short":["Neal, R. E.","Garcia, P. A.","Robertson, J. L.","Davalos, R. V."],"key":"RN212","id":"RN212","bibbaseid":"neal-garcia-robertson-davalos-experimentalcharacterizationofintrapulsetissueconductivitychangesforelectroporation-2011","role":"author","urls":{},"keyword":["Animals Computer Simulation Dose-Response Relationship","Radiation Electric Conductivity Electromagnetic Fields Electroporation/*methods In Vitro Techniques Kidney Medulla/*physiology/*radiation effects *Models","Biological Radiation Dosage Swine"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["animals computer simulation dose-response relationship","radiation electric conductivity electromagnetic fields electroporation/*methods in vitro techniques kidney medulla/*physiology/*radiation effects *models","biological radiation dosage swine"],"search_terms":["experimental","characterization","intrapulse","tissue","conductivity","changes","electroporation","neal","garcia","robertson","davalos"],"title":"Experimental characterization of intrapulse tissue conductivity changes for electroporation","year":2011}