@article{RN195,
   author = {Neal, R. E., 2nd and Millar, J. L. and Kavnoudias, H. and Royce, P. and Rosenfeldt, F. and Pham, A. and Smith, R. and Davalos, R. V. and Thomson, K. R.},
   title = {In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation},
   journal = {Prostate},
   volume = {74},
   number = {5},
   pages = {458-68},
   note = {1097-0045
Neal, Robert E 2nd
Millar, Jeremy L
Kavnoudias, Helen
Royce, Peter
Rosenfeldt, Franklin
Pham, Alan
Smith, Ryan
Davalos, Rafael V
Thomson, Kenneth R
Journal Article
Research Support, Non-U.S. Gov't
United States
2014/01/21
Prostate. 2014 May;74(5):458-68. doi: 10.1002/pros.22760. Epub 2014 Jan 17.},
   abstract = {BACKGROUND: Irreversible electroporation (IRE) delivers brief electric pulses to attain non-thermal focal ablation that spares vasculature and other sensitive systems. It is a promising prostate cancer treatment due to sparing of the tissues associated with morbidity risk from conventional therapies. IRE effects depend on electric field strength and tissue properties. These characteristics are organ-dependent, affecting IRE treatment outcomes. This study characterizes the relevant properties to improve treatment planning and outcome predictions for IRE prostate cancer treatment. METHODS: Clinically relevant IRE pulse protocols were delivered to a healthy canine and two human cancerous prostates while measuring electrical parameters to determine tissue characteristics for predictive treatment simulations. Prostates were resected 5 hr, 3 weeks, and 4 weeks post-IRE. Lesions were correlated with numerical simulations to determine an effective prostate lethal IRE electric field threshold. RESULTS: Lesions were produced in all subjects. Tissue electrical conductivity increased from 0.284 to 0.927 S/m due to IRE pulses. Numerical simulations show an average effective prostate electric field threshold of 1072 ± 119 V/cm, significantly higher than previously characterized tissues. Histological findings in the human cases show instances of complete tissue necrosis centrally with variable tissue effects beyond the margin. CONCLUSIONS: Preliminary experimental IRE trials safely ablated healthy canine and cancerous human prostates, as examined in the short- and medium-term. IRE-relevant prostate properties are now experimentally and numerically defined. Importantly, the electric field required to kill healthy prostate tissue is substantially higher than previously characterized tissues. These findings can be applied to optimize IRE prostate cancer treatment protocols.},
   keywords = {Animals
Computer Simulation
Dogs
Electric Conductivity
Electrochemotherapy/*methods
Humans
Male
Models, Biological
Prostate/pathology/*physiopathology
Prostatic Neoplasms/pathology/physiopathology/*therapy
Ire
finite element modeling
preclinical trials
prostate cancer
targeted therapy
translational research},
   ISSN = {0270-4137},
   DOI = {10.1002/pros.22760},
   year = {2014},
   type = {Journal Article}
}

{"_id":"2NiQP85KQQzDhN9Rv","bibbaseid":"neal-millar-kavnoudias-royce-rosenfeldt-pham-smith-davalos-etal-invivocharacterizationandnumericalsimulationofprostatepropertiesfornonthermalirreversibleelectroporationablation-2014","author_short":["Neal, R. E.","Millar, J. L.","Kavnoudias, H.","Royce, P.","Rosenfeldt, F.","Pham, A.","Smith, R.","Davalos, R. V.","Thomson, K. R."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Millar"],"firstnames":["J.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Kavnoudias"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Royce"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Rosenfeldt"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Pham"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Smith"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Thomson"],"firstnames":["K.","R."],"suffixes":[]}],"title":"In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation","journal":"Prostate","volume":"74","number":"5","pages":"458-68","note":"1097-0045 Neal, Robert E 2nd Millar, Jeremy L Kavnoudias, Helen Royce, Peter Rosenfeldt, Franklin Pham, Alan Smith, Ryan Davalos, Rafael V Thomson, Kenneth R Journal Article Research Support, Non-U.S. Gov't United States 2014/01/21 Prostate. 2014 May;74(5):458-68. doi: 10.1002/pros.22760. Epub 2014 Jan 17.","abstract":"BACKGROUND: Irreversible electroporation (IRE) delivers brief electric pulses to attain non-thermal focal ablation that spares vasculature and other sensitive systems. It is a promising prostate cancer treatment due to sparing of the tissues associated with morbidity risk from conventional therapies. IRE effects depend on electric field strength and tissue properties. These characteristics are organ-dependent, affecting IRE treatment outcomes. This study characterizes the relevant properties to improve treatment planning and outcome predictions for IRE prostate cancer treatment. METHODS: Clinically relevant IRE pulse protocols were delivered to a healthy canine and two human cancerous prostates while measuring electrical parameters to determine tissue characteristics for predictive treatment simulations. Prostates were resected 5 hr, 3 weeks, and 4 weeks post-IRE. Lesions were correlated with numerical simulations to determine an effective prostate lethal IRE electric field threshold. RESULTS: Lesions were produced in all subjects. Tissue electrical conductivity increased from 0.284 to 0.927 S/m due to IRE pulses. Numerical simulations show an average effective prostate electric field threshold of 1072 ± 119 V/cm, significantly higher than previously characterized tissues. Histological findings in the human cases show instances of complete tissue necrosis centrally with variable tissue effects beyond the margin. CONCLUSIONS: Preliminary experimental IRE trials safely ablated healthy canine and cancerous human prostates, as examined in the short- and medium-term. IRE-relevant prostate properties are now experimentally and numerically defined. Importantly, the electric field required to kill healthy prostate tissue is substantially higher than previously characterized tissues. These findings can be applied to optimize IRE prostate cancer treatment protocols.","keywords":"Animals Computer Simulation Dogs Electric Conductivity Electrochemotherapy/*methods Humans Male Models, Biological Prostate/pathology/*physiopathology Prostatic Neoplasms/pathology/physiopathology/*therapy Ire finite element modeling preclinical trials prostate cancer targeted therapy translational research","issn":"0270-4137","doi":"10.1002/pros.22760","year":"2014","bibtex":"@article{RN195,\n author = {Neal, R. E., 2nd and Millar, J. L. and Kavnoudias, H. and Royce, P. and Rosenfeldt, F. and Pham, A. and Smith, R. and Davalos, R. V. and Thomson, K. R.},\n title = {In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation},\n journal = {Prostate},\n volume = {74},\n number = {5},\n pages = {458-68},\n note = {1097-0045\nNeal, Robert E 2nd\nMillar, Jeremy L\nKavnoudias, Helen\nRoyce, Peter\nRosenfeldt, Franklin\nPham, Alan\nSmith, Ryan\nDavalos, Rafael V\nThomson, Kenneth R\nJournal Article\nResearch Support, Non-U.S. Gov't\nUnited States\n2014/01/21\nProstate. 2014 May;74(5):458-68. doi: 10.1002/pros.22760. Epub 2014 Jan 17.},\n abstract = {BACKGROUND: Irreversible electroporation (IRE) delivers brief electric pulses to attain non-thermal focal ablation that spares vasculature and other sensitive systems. It is a promising prostate cancer treatment due to sparing of the tissues associated with morbidity risk from conventional therapies. IRE effects depend on electric field strength and tissue properties. These characteristics are organ-dependent, affecting IRE treatment outcomes. This study characterizes the relevant properties to improve treatment planning and outcome predictions for IRE prostate cancer treatment. METHODS: Clinically relevant IRE pulse protocols were delivered to a healthy canine and two human cancerous prostates while measuring electrical parameters to determine tissue characteristics for predictive treatment simulations. Prostates were resected 5 hr, 3 weeks, and 4 weeks post-IRE. Lesions were correlated with numerical simulations to determine an effective prostate lethal IRE electric field threshold. RESULTS: Lesions were produced in all subjects. Tissue electrical conductivity increased from 0.284 to 0.927 S/m due to IRE pulses. Numerical simulations show an average effective prostate electric field threshold of 1072 ± 119 V/cm, significantly higher than previously characterized tissues. Histological findings in the human cases show instances of complete tissue necrosis centrally with variable tissue effects beyond the margin. CONCLUSIONS: Preliminary experimental IRE trials safely ablated healthy canine and cancerous human prostates, as examined in the short- and medium-term. IRE-relevant prostate properties are now experimentally and numerically defined. Importantly, the electric field required to kill healthy prostate tissue is substantially higher than previously characterized tissues. These findings can be applied to optimize IRE prostate cancer treatment protocols.},\n keywords = {Animals\nComputer Simulation\nDogs\nElectric Conductivity\nElectrochemotherapy/*methods\nHumans\nMale\nModels, Biological\nProstate/pathology/*physiopathology\nProstatic Neoplasms/pathology/physiopathology/*therapy\nIre\nfinite element modeling\npreclinical trials\nprostate cancer\ntargeted therapy\ntranslational research},\n ISSN = {0270-4137},\n DOI = {10.1002/pros.22760},\n year = {2014},\n type = {Journal Article}\n}\n\n","author_short":["Neal, R. E.","Millar, J. L.","Kavnoudias, H.","Royce, P.","Rosenfeldt, F.","Pham, A.","Smith, R.","Davalos, R. V.","Thomson, K. R."],"key":"RN195","id":"RN195","bibbaseid":"neal-millar-kavnoudias-royce-rosenfeldt-pham-smith-davalos-etal-invivocharacterizationandnumericalsimulationofprostatepropertiesfornonthermalirreversibleelectroporationablation-2014","role":"author","urls":{},"keyword":["Animals Computer Simulation Dogs Electric Conductivity Electrochemotherapy/*methods Humans Male Models","Biological Prostate/pathology/*physiopathology Prostatic Neoplasms/pathology/physiopathology/*therapy Ire finite element modeling preclinical trials prostate cancer targeted therapy translational research"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["animals computer simulation dogs electric conductivity electrochemotherapy/*methods humans male models","biological prostate/pathology/*physiopathology prostatic neoplasms/pathology/physiopathology/*therapy ire finite element modeling preclinical trials prostate cancer targeted therapy translational research"],"search_terms":["vivo","characterization","numerical","simulation","prostate","properties","non","thermal","irreversible","electroporation","ablation","neal","millar","kavnoudias","royce","rosenfeldt","pham","smith","davalos","thomson"],"title":"In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation","year":2014}