@article{RN232,
   author = {Neal, R. E., 2nd and Singh, R. and Hatcher, H. C. and Kock, N. D. and Torti, S. V. and Davalos, R. V.},
   title = {Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode},
   journal = {Breast Cancer Res Treat},
   volume = {123},
   number = {1},
   pages = {295-301},
   note = {1573-7217
Neal, Robert E 2nd
Singh, Ravi
Hatcher, Heather C
Kock, Nancy D
Torti, Suzy V
Davalos, Rafael V
R01 CA128428/CA/NCI NIH HHS/United States
T32 CA079448/CA/NCI NIH HHS/United States
R01CA12842/CA/NCI NIH HHS/United States
T32 CA-079448/CA/NCI NIH HHS/United States
R01 CA128428-03/CA/NCI NIH HHS/United States
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Netherlands
2010/03/02
Breast Cancer Res Treat. 2010 Aug;123(1):295-301. doi: 10.1007/s10549-010-0803-5. Epub 2010 Feb 27.},
   abstract = {Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.},
   keywords = {Animals
Cell Line, Tumor
Electrochemotherapy/*instrumentation/*methods
Electrodes
Female
Humans
Mammary Neoplasms, Experimental/pathology/*therapy
Mice
Mice, Nude
*Needles
Xenograft Model Antitumor Assays},
   ISSN = {0167-6806 (Print)
0167-6806},
   DOI = {10.1007/s10549-010-0803-5},
   year = {2010},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Singh"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Hatcher"],"firstnames":["H.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Kock"],"firstnames":["N.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Torti"],"firstnames":["S.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode","journal":"Breast Cancer Res Treat","volume":"123","number":"1","pages":"295-301","note":"1573-7217 Neal, Robert E 2nd Singh, Ravi Hatcher, Heather C Kock, Nancy D Torti, Suzy V Davalos, Rafael V R01 CA128428/CA/NCI NIH HHS/United States T32 CA079448/CA/NCI NIH HHS/United States R01CA12842/CA/NCI NIH HHS/United States T32 CA-079448/CA/NCI NIH HHS/United States R01 CA128428-03/CA/NCI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Netherlands 2010/03/02 Breast Cancer Res Treat. 2010 Aug;123(1):295-301. doi: 10.1007/s10549-010-0803-5. Epub 2010 Feb 27.","abstract":"Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.","keywords":"Animals Cell Line, Tumor Electrochemotherapy/*instrumentation/*methods Electrodes Female Humans Mammary Neoplasms, Experimental/pathology/*therapy Mice Mice, Nude *Needles Xenograft Model Antitumor Assays","issn":"0167-6806 (Print) 0167-6806","doi":"10.1007/s10549-010-0803-5","year":"2010","bibtex":"@article{RN232,\n author = {Neal, R. E., 2nd and Singh, R. and Hatcher, H. C. and Kock, N. D. and Torti, S. V. and Davalos, R. V.},\n title = {Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode},\n journal = {Breast Cancer Res Treat},\n volume = {123},\n number = {1},\n pages = {295-301},\n note = {1573-7217\nNeal, Robert E 2nd\nSingh, Ravi\nHatcher, Heather C\nKock, Nancy D\nTorti, Suzy V\nDavalos, Rafael V\nR01 CA128428/CA/NCI NIH HHS/United States\nT32 CA079448/CA/NCI NIH HHS/United States\nR01CA12842/CA/NCI NIH HHS/United States\nT32 CA-079448/CA/NCI NIH HHS/United States\nR01 CA128428-03/CA/NCI NIH HHS/United States\nJournal Article\nResearch Support, N.I.H., Extramural\nResearch Support, Non-U.S. Gov't\nNetherlands\n2010/03/02\nBreast Cancer Res Treat. 2010 Aug;123(1):295-301. doi: 10.1007/s10549-010-0803-5. Epub 2010 Feb 27.},\n abstract = {Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.},\n keywords = {Animals\nCell Line, Tumor\nElectrochemotherapy/*instrumentation/*methods\nElectrodes\nFemale\nHumans\nMammary Neoplasms, Experimental/pathology/*therapy\nMice\nMice, Nude\n*Needles\nXenograft Model Antitumor Assays},\n ISSN = {0167-6806 (Print)\n0167-6806},\n DOI = {10.1007/s10549-010-0803-5},\n year = {2010},\n type = {Journal Article}\n}\n\n","author_short":["Neal, R. E.","Singh, R.","Hatcher, H. C.","Kock, N. D.","Torti, S. V.","Davalos, R. V."],"key":"RN232","id":"RN232","bibbaseid":"neal-singh-hatcher-kock-torti-davalos-treatmentofbreastcancerthroughtheapplicationofirreversibleelectroporationusinganovelminimallyinvasivesingleneedleelectrode-2010","role":"author","urls":{},"keyword":["Animals Cell Line","Tumor Electrochemotherapy/*instrumentation/*methods Electrodes Female Humans Mammary Neoplasms","Experimental/pathology/*therapy Mice Mice","Nude *Needles Xenograft Model Antitumor Assays"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["animals cell line","tumor electrochemotherapy/*instrumentation/*methods electrodes female humans mammary neoplasms","experimental/pathology/*therapy mice mice","nude *needles xenograft model antitumor assays"],"search_terms":["treatment","breast","cancer","through","application","irreversible","electroporation","using","novel","minimally","invasive","single","needle","electrode","neal","singh","hatcher","kock","torti","davalos"],"title":"Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode","year":2010}