@ARTICLE{Nekhai2014,
author={Nekhai, S. and Petukhov, M. and Breuer, D.},
title={Regulation of CDK9 activity by phosphorylation and dephosphorylation},
journal={BioMed Research International},
year={2014},
volume={2014},
doi={10.1155/2014/964964},
art_number={964964},
note={cited By 14},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893776798&doi=10.1155%2f2014%2f964964&partnerID=40&md5=43597b129d4bdb05cf26f67f09aeefbe},
affiliation={Center for Sickle Cell Disease, Department of Medicine, Howard University, 520 W Street, N.W., Washington, DC 20059, United States; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Gatchina 188350, Russian Federation; Department of Biophysics, St. Petersburg State Polytechnical University, Polytechnicheskaya Street 29, St. Petersburg 195251, Russian Federation},
abstract={HIV-1 transcription is regulated by CDK9/cyclin T1, which, unlike a typical cell cycle-dependent kinase, is regulated by associating with 7SK small nuclear ribonuclear protein complex (snRNP). While the protein components of this complex are well studied, the mechanism of the complex formation is still not fully understood. The association of CDK9/cyclin T1 with 7SK snRNP is, in part, regulated by a reversible CDK9 phosphorylation. Here, we present a comprehensive review of the kinases and phosphatases involved in CDK9 phosphorylation and discuss their role in regulation of HIV-1 replication and potential for being targeted for drug development. We propose a novel pathway of HIV-1 transcription regulation via CDK9 Ser-90 phosphorylation by CDK2 and CDK9 Ser-175 dephosphorylation by protein phosphatase-1. © 2014 Sergei Nekhai et al.},
correspondence_address1={Nekhai, S.; Center for Sickle Cell Disease, Department of Medicine, Howard University, 520 W Street, N.W., Washington, DC 20059, United States; email: snekhai@howard.edu},
issn={23146133},
pubmed_id={24524087},
language={English},
abbrev_source_title={BioMed Res. Int.},
document_type={Review},
source={Scopus},
}

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