Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant. Nesamari, R., Omondi, M. A, Baguma, R., Höft, M. A, Ngomti, A., Nkayi, A. A, Besethi, A. S, Magugu, S. F J, Mosala, P., Walters, A., Clark, G. M, Mennen, M., Skelem, S., Adriaanse, M., Grifoni, A., Sette, A., Keeton, R. S, Ntusi, N. A B, Riou, C., & Burgers, W. A Cell Host & Microbe, 32(2):162–169, Cell Press, feb, 2024. ![Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has given rise to recombinant Omicron lineages that dominate globally (XBB.1), as well as the emergence of hypermutated variants (BA.2.86). In this context, durable and cross-reactive T cell immune memory is critical for continued protection against severe COVID-19. We examined T cell responses to SARS-CoV-2 approximately 1.5 years since Omicron first emerged. We describe sustained CD4+ and CD8+ spike-specific T cell memory responses in healthcare workers in South Africa (n = 39) who were vaccinated and experienced at least one SARS-CoV-2 infection. Spike-specific T cells are highly cross-reactive with all Omicron variants tested, including BA.2.86. Abundant nucleocapsid and membrane-specific T cells are detectable in most participants. The bulk of SARS-CoV-2-specific T cell responses have an early-differentiated phenotype, explaining their persistent nature. Overall, hybrid immunity leads to the accumulation of spike and non-spike T cells evident 3.5 years after the start of the pandemic, with preserved recognition of highly mutated SARS-CoV-2 variants.
@article{Nesamari2024,
abstract = {Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has given rise to recombinant Omicron lineages that dominate globally (XBB.1), as well as the emergence of hypermutated variants (BA.2.86). In this context, durable and cross-reactive T cell immune memory is critical for continued protection against severe COVID-19. We examined T cell responses to SARS-CoV-2 approximately 1.5 years since Omicron first emerged. We describe sustained CD4+ and CD8+ spike-specific T cell memory responses in healthcare workers in South Africa (n = 39) who were vaccinated and experienced at least one SARS-CoV-2 infection. Spike-specific T cells are highly cross-reactive with all Omicron variants tested, including BA.2.86. Abundant nucleocapsid and membrane-specific T cells are detectable in most participants. The bulk of SARS-CoV-2-specific T cell responses have an early-differentiated phenotype, explaining their persistent nature. Overall, hybrid immunity leads to the accumulation of spike and non-spike T cells evident 3.5 years after the start of the pandemic, with preserved recognition of highly mutated SARS-CoV-2 variants.},
author = {Nesamari, Rofhiwa and Omondi, Millicent A and Baguma, Richard and H{\"{o}}ft, Maxine A and Ngomti, Amkele and Nkayi, Anathi A and Besethi, Asiphe S and Magugu, Siyabulela F J and Mosala, Paballo and Walters, Avril and Clark, Gesina M and Mennen, Mathilda and Skelem, Sango and Adriaanse, Marguerite and Grifoni, Alba and Sette, Alessandro and Keeton, Roanne S and Ntusi, Ntobeko A B and Riou, Catherine and Burgers, Wendy A},
doi = {10.1016/J.CHOM.2023.12.003},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Nesamari et al. - 2024 - Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hype.pdf:pdf},
issn = {1931-3128},
journal = {Cell Host {\&} Microbe},
keywords = {OA,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {feb},
number = {2},
pages = {162--169},
pmid = {38211583},
publisher = {Cell Press},
title = {{Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/38211583},
volume = {32},
year = {2024}
}
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