Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis sixteen years after anterior cruciate ligament injury. Neuman, P., Dahlberg, L. E., Englund, M., & Struglics, A.
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OBJECTIVE: To describe the longitudinal patterns of release, and investigate the association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury. DESIGN: Synovial fluid was aspirated from the acutely ACL injured knee within the first two weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 in synovial fluid were quantified by immunoassays. The presence of radiographic tibiofemoral or patellofemoral OA (Kellgren and Lawrence \textgreater/=2) was examined with weight-bearing knee radiography 16 years after the ACL injury. RESULTS: The average acute and chronic SF concentrations of COMP and aggrecan were elevated in comparison with the reference group (p \textless 0.001). The levels of COMP and aggrecan clearly decreased approximately half a year after the ACL injury, and returned to reference values during the 7.5 years of follow-up. Using logistic regression analysis neither acute nor chronic concentrations of the four biomarkers were associated with the development of radiographic knee OA at the 16 year follow-up. CONCLUSION: Increased synovial fluid concentrations of aggrecan and COMP was related to knee injury, but acute and chronic synovial fluid concentrations of aggrecan, COMP,
@article{neuman_concentrations_2016,
	title = {Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis sixteen years after anterior cruciate ligament injury.},
	rights = {Copyright (c) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
	issn = {1522-9653 1063-4584},
	doi = {10.1016/j.joca.2016.09.008},
	abstract = {{OBJECTIVE}: To describe the longitudinal patterns of release, and investigate the  association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis ({OA}) after an anterior cruciate ligament ({ACL}) injury. {DESIGN}: Synovial fluid was aspirated from the acutely {ACL} injured knee within the first two weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60\% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein ({COMP}), matrix metalloproteinase ({MMP})-3 and tissue inhibitor of metalloproteinase ({TIMP})-1 in synovial fluid were quantified by immunoassays. The presence of radiographic tibiofemoral or patellofemoral {OA} (Kellgren and Lawrence {\textgreater}/=2) was examined with weight-bearing knee radiography 16 years after the {ACL} injury. {RESULTS}: The average acute and chronic {SF} concentrations of {COMP} and aggrecan were elevated in comparison with the reference group (p {\textless} 0.001). The levels of {COMP} and aggrecan clearly decreased approximately half a year after the {ACL} injury, and returned to reference values  during the 7.5 years of follow-up. Using logistic regression analysis neither acute nor chronic concentrations of the four biomarkers were associated with the  development of radiographic knee {OA} at the 16 year follow-up. {CONCLUSION}: Increased synovial fluid concentrations of aggrecan and {COMP} was related to knee  injury, but acute and chronic synovial fluid concentrations of aggrecan, {COMP},},
	journaltitle = {Osteoarthritis and cartilage},
	shortjournal = {Osteoarthritis Cartilage},
	author = {Neuman, Paul and Dahlberg, Leif E. and Englund, Martin and Struglics, Andre},
	date = {2016-09-18},
	pmid = {27654964},
	keywords = {{ACL}, biomarkers, Knee {OA}, synovial fluid}
}
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