@article{neuman_concentrations_2016,
	title = {Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis sixteen years after anterior cruciate ligament injury.},
	rights = {Copyright (c) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
	issn = {1522-9653 1063-4584},
	doi = {10.1016/j.joca.2016.09.008},
	abstract = {{OBJECTIVE}: To describe the longitudinal patterns of release, and investigate the  association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis ({OA}) after an anterior cruciate ligament ({ACL}) injury. {DESIGN}: Synovial fluid was aspirated from the acutely {ACL} injured knee within the first two weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60\% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein ({COMP}), matrix metalloproteinase ({MMP})-3 and tissue inhibitor of metalloproteinase ({TIMP})-1 in synovial fluid were quantified by immunoassays. The presence of radiographic tibiofemoral or patellofemoral {OA} (Kellgren and Lawrence {\textgreater}/=2) was examined with weight-bearing knee radiography 16 years after the {ACL} injury. {RESULTS}: The average acute and chronic {SF} concentrations of {COMP} and aggrecan were elevated in comparison with the reference group (p {\textless} 0.001). The levels of {COMP} and aggrecan clearly decreased approximately half a year after the {ACL} injury, and returned to reference values  during the 7.5 years of follow-up. Using logistic regression analysis neither acute nor chronic concentrations of the four biomarkers were associated with the  development of radiographic knee {OA} at the 16 year follow-up. {CONCLUSION}: Increased synovial fluid concentrations of aggrecan and {COMP} was related to knee  injury, but acute and chronic synovial fluid concentrations of aggrecan, {COMP},},
	journaltitle = {Osteoarthritis and cartilage},
	shortjournal = {Osteoarthritis Cartilage},
	author = {Neuman, Paul and Dahlberg, Leif E. and Englund, Martin and Struglics, Andre},
	date = {2016-09-18},
	pmid = {27654964},
	keywords = {{ACL}, biomarkers, Knee {OA}, synovial fluid}
}