Knee cartilage assessment with MRI (dGEMRIC) and subjective knee function in ACL injured copers: a cohort study with a 20 year follow-up. Neuman, P., Owman, H., Müller, G., Englund, M., Tiderius, C. J., & Dahlberg, L. E. 22(1):84--90.
doi  abstract   bibtex   
OBJECTIVE: To assess knee cartilage quality and subjective knee function, 20 years after injury in anterior cruciate ligament (ACL) injured copers. METHOD: We examined 32 knees using delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC), 20 years after a complete ACL tear. Only subjects who had coped with the ACL injury without ACL reconstruction (ACLR), and who presented without radiographic signs of osteoarthritis (OA) at an earlier 16-year follow-up, were included in this study. The quality of the central weight-bearing parts of the medial and lateral femoral cartilage was estimated with dGEMRIC (T1Gd). These results were compared with corresponding results in 24 healthy individuals, and with the subjects' self-reported subjective knee function using the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. RESULTS: The values of T1Gd in the medial and lateral femoral cartilage of the study group (mean (95% CI)), were 404 (385-423) and 427 (399-455) ms, not statistically different from those of the healthy reference group (P = 0.065 and 0.31). The subjective knee function 20 years after the injury, according to the five domains of the KOOS score, was good, with a mean score of 90 ± 11. Values of T1Gd for the medial femoral cartilage were correlated with the KOOS subgroup QOL (P = 0.021, Pearson correlation). CONCLUSIONS: Subjects who have managed to cope with their ACL injury for 20 years with sustained good subjective knee function also seem to have knee cartilage of good quality, with T1Gd values not very different from a healthy reference group.
@article{neuman_knee_2014,
	title = {Knee cartilage assessment with {MRI} ({dGEMRIC}) and subjective knee function in {ACL} injured copers: a cohort study with a 20 year follow-up},
	volume = {22},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2013.10.006},
	shorttitle = {Knee cartilage assessment with {MRI} ({dGEMRIC}) and subjective knee function in {ACL} injured copers},
	abstract = {{OBJECTIVE}: To assess knee cartilage quality and subjective knee function, 20 years after injury in anterior cruciate ligament ({ACL}) injured copers.
{METHOD}: We examined 32 knees using delayed gadolinium-enhanced magnetic resonance imaging ({MRI}) of cartilage ({dGEMRIC}), 20 years after a complete {ACL} tear. Only subjects who had coped with the {ACL} injury without {ACL} reconstruction ({ACLR}), and who presented without radiographic signs of osteoarthritis ({OA}) at an earlier 16-year follow-up, were included in this study. The quality of the central weight-bearing parts of the medial and lateral femoral cartilage was estimated with {dGEMRIC} (T1Gd). These results were compared with corresponding results in 24 healthy individuals, and with the subjects' self-reported subjective knee function using the Knee Injury and Osteoarthritis Outcome Score ({KOOS}) questionnaire.
{RESULTS}: The values of T1Gd in the medial and lateral femoral cartilage of the study group (mean (95\% {CI})), were 404 (385-423) and 427 (399-455) ms, not statistically different from those of the healthy reference group (P = 0.065 and 0.31). The subjective knee function 20 years after the injury, according to the five domains of the {KOOS} score, was good, with a mean score of 90 ± 11. Values of T1Gd for the medial femoral cartilage were correlated with the {KOOS} subgroup {QOL} (P = 0.021, Pearson correlation).
{CONCLUSIONS}: Subjects who have managed to cope with their {ACL} injury for 20 years with sustained good subjective knee function also seem to have knee cartilage of good quality, with T1Gd values not very different from a healthy reference group.},
	pages = {84--90},
	number = {1},
	journaltitle = {Osteoarthritis and cartilage / {OARS}, Osteoarthritis Research Society},
	shortjournal = {Osteoarthr. Cartil.},
	author = {Neuman, P. and Owman, H. and Müller, G. and Englund, M. and Tiderius, C. J. and Dahlberg, L. E.},
	date = {2014-01},
	pmid = {24185106},
	keywords = {Adaptation, Psychological, Adult, Anterior Cruciate Ligament, Anterior cruciate ligament injury, Cartilage, Articular, Cohort Studies, Contrast Media, {dGEMRIC}, Female, Follow-Up Studies, Gadolinium {DTPA}, Humans, Knee, Knee Injuries, Knee Joint, Magnetic resonance imaging, Male, Meniscus injury, Middle Aged, {MRI}, Osteoarthritis, Prognosis, Recovery of Function, Self Report}
}
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