@article{neuman_longitudinal_2011,
	title = {Longitudinal assessment of femoral knee cartilage quality using contrast enhanced {MRI} ({dGEMRIC}) in patients with anterior cruciate ligament injury--comparison with asymptomatic volunteers},
	volume = {19},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2011.05.002},
	abstract = {{OBJECTIVE}: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan ({GAG}) content, in patients with an acute anterior cruciate ligament ({ACL}) injury, with or without a concomitant meniscus injury.
{METHODS}: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage ({dGEMRIC}), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. We estimated the {GAG} content (T1Gd) in the central weight-bearing parts of the medial and lateral femoral cartilage and compared results with a reference cohort (n=24) with normal knees and no history of injury examined by {dGEMRIC} at one occasion previously.
{RESULTS}: The healthy reference group had longer T1Gd values compared with the {ACL}-injured patients at follow-up both medially: 428±38 vs 363±61ms (P{\textless}0.0001) and laterally: 445±41 vs 396±48ms (P=0.0002). At follow-up T1Gd was lower in meniscectomized patients compared to those without a meniscectomy, both medially (-84ms, P=0.002) and laterally (-38ms, P=0.05). In the injured group, the medial femoral cartilage showed similar T1Gd at the two {dGEMRIC} investigations: 357±50 vs 363±61ms (P=0.57), whereas the lateral femoral cartilage T1Gd increased: 374±48 vs 396±48ms (P=0.04).
{CONCLUSIONS}: The general decrease in cartilage T1Gd in {ACL}-injured patients compared with references provide evidence for structural matrix {GAG} changes that seem more pronounced if a concomitant meniscal injury is present. The fact that post-traumatic {OA} commonly develops in {ACL}-injured patients, in particularly those with meniscectomy, suggests that shorter T1Gd may be an early biomarker for {OA}.},
	pages = {977--983},
	number = {8},
	journaltitle = {Osteoarthritis and cartilage / {OARS}, Osteoarthritis Research Society},
	shortjournal = {Osteoarthr. Cartil.},
	author = {Neuman, P. and Tjörnstrand, J. and Svensson, J. and Ragnarsson, C. and Roos, H. and Englund, M. and Tiderius, C. J. and Dahlberg, L. E.},
	date = {2011-08},
	pmid = {21621622},
	keywords = {Adolescent, Adult, Anterior Cruciate Ligament, Cartilage, Articular, Case-Control Studies, Contrast Media, Female, Follow-Up Studies, Gadolinium {DTPA}, Glycosaminoglycans, Humans, Joint Diseases, Knee Joint, Longitudinal Studies, Magnetic resonance imaging, Male, Young Adult}
}

{"_id":"6Eh2WQ5r3NW8DCy6q","bibbaseid":"neuman-tjrnstrand-svensson-ragnarsson-roos-englund-tiderius-dahlberg-longitudinalassessmentoffemoralkneecartilagequalityusingcontrastenhancedmridgemricinpatientswithanteriorcruciateligamentinjurycomparisonwithasymptomaticvolunteers","downloads":0,"creationDate":"2017-03-31T11:02:37.121Z","title":"Longitudinal assessment of femoral knee cartilage quality using contrast enhanced MRI (dGEMRIC) in patients with anterior cruciate ligament injury--comparison with asymptomatic volunteers","author_short":["Neuman, P.","Tjörnstrand, J.","Svensson, J.","Ragnarsson, C.","Roos, H.","Englund, M.","Tiderius, C. J.","Dahlberg, L. E."],"year":null,"bibtype":"article","biburl":"http://clinicalepidemiology.se/ClinEpi_LU.bib","bibdata":{"bibtype":"article","type":"article","title":"Longitudinal assessment of femoral knee cartilage quality using contrast enhanced MRI (dGEMRIC) in patients with anterior cruciate ligament injury--comparison with asymptomatic volunteers","volume":"19","issn":"1522-9653","doi":"10.1016/j.joca.2011.05.002","abstract":"OBJECTIVE: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan (GAG) content, in patients with an acute anterior cruciate ligament (ACL) injury, with or without a concomitant meniscus injury. METHODS: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. We estimated the GAG content (T1Gd) in the central weight-bearing parts of the medial and lateral femoral cartilage and compared results with a reference cohort (n=24) with normal knees and no history of injury examined by dGEMRIC at one occasion previously. RESULTS: The healthy reference group had longer T1Gd values compared with the ACL-injured patients at follow-up both medially: 428±38 vs 363±61ms (P\\textless0.0001) and laterally: 445±41 vs 396±48ms (P=0.0002). At follow-up T1Gd was lower in meniscectomized patients compared to those without a meniscectomy, both medially (-84ms, P=0.002) and laterally (-38ms, P=0.05). In the injured group, the medial femoral cartilage showed similar T1Gd at the two dGEMRIC investigations: 357±50 vs 363±61ms (P=0.57), whereas the lateral femoral cartilage T1Gd increased: 374±48 vs 396±48ms (P=0.04). CONCLUSIONS: The general decrease in cartilage T1Gd in ACL-injured patients compared with references provide evidence for structural matrix GAG changes that seem more pronounced if a concomitant meniscal injury is present. The fact that post-traumatic OA commonly develops in ACL-injured patients, in particularly those with meniscectomy, suggests that shorter T1Gd may be an early biomarker for OA.","pages":"977--983","number":"8","journaltitle":"Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society","shortjournal":"Osteoarthr. Cartil.","author":[{"propositions":[],"lastnames":["Neuman"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Tjörnstrand"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Svensson"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Ragnarsson"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Roos"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Tiderius"],"firstnames":["C.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Dahlberg"],"firstnames":["L.","E."],"suffixes":[]}],"date":"2011-08","pmid":"21621622","keywords":"Adolescent, Adult, Anterior Cruciate Ligament, Cartilage, Articular, Case-Control Studies, Contrast Media, Female, Follow-Up Studies, Gadolinium DTPA, Glycosaminoglycans, Humans, Joint Diseases, Knee Joint, Longitudinal Studies, Magnetic resonance imaging, Male, Young Adult","bibtex":"@article{neuman_longitudinal_2011,\n\ttitle = {Longitudinal assessment of femoral knee cartilage quality using contrast enhanced {MRI} ({dGEMRIC}) in patients with anterior cruciate ligament injury--comparison with asymptomatic volunteers},\n\tvolume = {19},\n\tissn = {1522-9653},\n\tdoi = {10.1016/j.joca.2011.05.002},\n\tabstract = {{OBJECTIVE}: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan ({GAG}) content, in patients with an acute anterior cruciate ligament ({ACL}) injury, with or without a concomitant meniscus injury.\n{METHODS}: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage ({dGEMRIC}), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. We estimated the {GAG} content (T1Gd) in the central weight-bearing parts of the medial and lateral femoral cartilage and compared results with a reference cohort (n=24) with normal knees and no history of injury examined by {dGEMRIC} at one occasion previously.\n{RESULTS}: The healthy reference group had longer T1Gd values compared with the {ACL}-injured patients at follow-up both medially: 428±38 vs 363±61ms (P{\\textless}0.0001) and laterally: 445±41 vs 396±48ms (P=0.0002). At follow-up T1Gd was lower in meniscectomized patients compared to those without a meniscectomy, both medially (-84ms, P=0.002) and laterally (-38ms, P=0.05). In the injured group, the medial femoral cartilage showed similar T1Gd at the two {dGEMRIC} investigations: 357±50 vs 363±61ms (P=0.57), whereas the lateral femoral cartilage T1Gd increased: 374±48 vs 396±48ms (P=0.04).\n{CONCLUSIONS}: The general decrease in cartilage T1Gd in {ACL}-injured patients compared with references provide evidence for structural matrix {GAG} changes that seem more pronounced if a concomitant meniscal injury is present. The fact that post-traumatic {OA} commonly develops in {ACL}-injured patients, in particularly those with meniscectomy, suggests that shorter T1Gd may be an early biomarker for {OA}.},\n\tpages = {977--983},\n\tnumber = {8},\n\tjournaltitle = {Osteoarthritis and cartilage / {OARS}, Osteoarthritis Research Society},\n\tshortjournal = {Osteoarthr. Cartil.},\n\tauthor = {Neuman, P. and Tjörnstrand, J. and Svensson, J. and Ragnarsson, C. and Roos, H. and Englund, M. and Tiderius, C. J. and Dahlberg, L. 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