@article{Ni2017,
	title = {Chemical modifications of nucleic acid aptamers for therapeutic purposes},
	volume = {18},
	issn = {1422-0067},
	url = {http://www.mdpi.com/1422-0067/18/8/1683},
	doi = {10.3390/ijms18081683},
	abstract = {Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.},
	number = {8},
	journal = {International Journal of Molecular Sciences},
	author = {Ni, Shuaijian and Yao, Houzong and Wang, Lili and Lu, Jun and Jiang, Feng and Lu, Aiping and Zhang, Ge},
	month = aug,
	year = {2017},
	note = {tex.ids= niChemicalModificationsNucleic2017},
	keywords = {\#nosource, Binding affinity, Chemical modification, Nuclease degradation, Nucleic acid aptamer, Rapid excretion},
	pages = {1683},
}

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