Metabonomics: A platform for studying drug toxicity and gene function.

Metabonomics: A platform for studying drug toxicity and gene function. Nicholson, J. K, Connelly, J., Lindon, J. C, & Holmes, E. Nat Rev Drug Discov, 1(2):153–161, 2002.
doi abstract bibtex

The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.

@Article{nicholson02metabonomics,
  author    = {Jeremy K Nicholson and John Connelly and John C Lindon and Elaine Holmes},
  title     = {Metabonomics: A platform for studying drug toxicity and gene function.},
  journal   = {Nat Rev Drug Discov},
  year      = {2002},
  volume    = {1},
  number    = {2},
  pages     = {153--161},
  abstract  = {The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.},
  doi       = {10.1038/nrd728},
  keywords  = {Animals; Drug Design; Drug Industry; Genes; Genomics; Humans; Kidney, drug effects; Liver, drug effects; Magnetic Resonance Spectroscopy; Toxicology},
  optmonth  = feb,
  owner     = {fhufsky},
  pmid      = {12120097},
  timestamp = {2011.06.28},
}

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