DNA cross-triggered cascading self-amplification artificial biochemical circuit. Nie, J., Zhao, M., Xie, W., J., Cai, L., Zhou, Y., & Zhang, X. Chemical Science, 6:1225-1229, 2015. ![DNA cross-triggered cascading self-amplification artificial biochemical circuit [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex The construction of compact and robust artificial biochemical circuits based on nucleic acids can help researchers to understand the essential mechanisms of complex biological systems, and design sophisticated strategies for various requirements. In this study, a novel DNA cross-triggered cascading self-amplification artificial biochemical circuit was developed. Once triggered by trace amounts (as low as 2 amol) of either of two fully independent oligonucleotide factors under homogeneous isothermal conditions, the circuit simultaneously amplified both factors by 105–107 fold, which was proved using mass spectrometry. The compact and robust circuit was successfully used to construct a multi-input Boolean logic operation and a sensitive DNA biosensor based on the dual-amplification of both the target and reporter. The circuit showed great potential for signal gain in complicated molecular programming, and flexible control of nucleic acid nanomachines in biochemical network systems and nanotechnology.
@article{
title = {DNA cross-triggered cascading self-amplification artificial biochemical circuit},
type = {article},
year = {2015},
keywords = {dual-amplification,enzyme,hybridization chain-reaction,isothermal amplification,micrornas,replication,rna,strand-displacement,ultrasensitive detection},
pages = {1225-1229},
volume = {6},
websites = {http://xlink.rsc.org/?DOI=C4SC03225J},
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created = {2017-09-28T14:05:00.537Z},
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last_modified = {2020-08-12T04:26:59.125Z},
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confirmed = {true},
hidden = {false},
citation_key = {Nie2015},
source_type = {Journal Article},
language = {English},
notes = {Az3sn<br/>Times Cited:3<br/>Cited References Count:29},
private_publication = {false},
abstract = {The construction of compact and robust artificial biochemical circuits based on nucleic acids can help researchers to understand the essential mechanisms of complex biological systems, and design sophisticated strategies for various requirements. In this study, a novel DNA cross-triggered cascading self-amplification artificial biochemical circuit was developed. Once triggered by trace amounts (as low as 2 amol) of either of two fully independent oligonucleotide factors under homogeneous isothermal conditions, the circuit simultaneously amplified both factors by 105–107 fold, which was proved using mass spectrometry. The compact and robust circuit was successfully used to construct a multi-input Boolean logic operation and a sensitive DNA biosensor based on the dual-amplification of both the target and reporter. The circuit showed great potential for signal gain in complicated molecular programming, and flexible control of nucleic acid nanomachines in biochemical network systems and nanotechnology.},
bibtype = {article},
author = {Nie, Ji and Zhao, Ming-Zhe and Xie, Wen Jun and Cai, Liang-Yuan and Zhou, Ying-Lin and Zhang, Xin-Xiang},
doi = {10.1039/C4SC03225J},
journal = {Chemical Science}
}
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