Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population. Niehaus, D. J., Kinnear, C. J., Corfield, V. A., du Toit, P. L., van Kradenburg, J., Moolman-Smook, J. C., Weyers, J. B., Potgieter, A., Seedat, S., Emsley, R. A., Knowles, J. A., Brink, P. A., & Stein, D. J. Journal of Affective Disorders, 65(1):61–65, June, 2001. 00063 abstract bibtex BACKGROUND: It has been proposed that the catechol-o-methyl transferase gene (COMT) may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Whereas studies in a North American population showed that the low activity (L) allele of a functional polymorphism in COMT was associated with OCD in male patients, this result was not supported by studies in a Japanese population. The present association study assessed the risk for OCD conferred by this COMT polymorphism in a geographically different patient group, namely, the relatively genetically homogeneous Afrikaner population of South Africa. METHODS: Fifty-four unrelated OCD patients and fifty-four sex-matched controls were recruited from the same Afrikaner community. Patients and controls were phenotyped (DSM-IV) and genotyped for a NlaIII polymorphism with H (high activity) or L (low activity) alleles in the COMT gene. RESULTS: The H/L genotype was significantly more common than expected in the OCD patient group (P = 0.0017). LIMITATIONS: Replication studies with related individuals may be useful in discovering factors underpinning the H/L genotype abundance in the Afrikaner population. CONCLUSIONS: These results emphasise the need for further studies in genetically homogeneous populations to help define the complex etiology of this disease.
@article{niehaus_association_2001,
title = {Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the {Afrikaner} population},
volume = {65},
issn = {0165-0327},
abstract = {BACKGROUND: It has been proposed that the catechol-o-methyl transferase gene (COMT) may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Whereas studies in a North American population showed that the low activity (L) allele of a functional polymorphism in COMT was associated with OCD in male patients, this result was not supported by studies in a Japanese population. The present association study assessed the risk for OCD conferred by this COMT polymorphism in a geographically different patient group, namely, the relatively genetically homogeneous Afrikaner population of South Africa.
METHODS: Fifty-four unrelated OCD patients and fifty-four sex-matched controls were recruited from the same Afrikaner community. Patients and controls were phenotyped (DSM-IV) and genotyped for a NlaIII polymorphism with H (high activity) or L (low activity) alleles in the COMT gene.
RESULTS: The H/L genotype was significantly more common than expected in the OCD patient group (P = 0.0017).
LIMITATIONS: Replication studies with related individuals may be useful in discovering factors underpinning the H/L genotype abundance in the Afrikaner population.
CONCLUSIONS: These results emphasise the need for further studies in genetically homogeneous populations to help define the complex etiology of this disease.},
language = {eng},
number = {1},
journal = {Journal of Affective Disorders},
author = {Niehaus, D. J. and Kinnear, C. J. and Corfield, V. A. and du Toit, P. L. and van Kradenburg, J. and Moolman-Smook, J. C. and Weyers, J. B. and Potgieter, A. and Seedat, S. and Emsley, R. A. and Knowles, J. A. and Brink, P. A. and Stein, D. J.},
month = jun,
year = {2001},
pmid = {11426511},
note = {00063 },
keywords = {Adult, Alleles, Catechol O-Methyltransferase, Cross-Cultural Comparison, Female, Genetics, Population, Genotype, Humans, Male, Obsessive-Compulsive Disorder, Polymorphism, Genetic, South Africa},
pages = {61--65},
}
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J."],"year":2001,"bibtype":"article","biburl":"http://bibbase.org/zotero/TBHostGen","bibdata":{"bibtype":"article","type":"article","title":"Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population","volume":"65","issn":"0165-0327","abstract":"BACKGROUND: It has been proposed that the catechol-o-methyl transferase gene (COMT) may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Whereas studies in a North American population showed that the low activity (L) allele of a functional polymorphism in COMT was associated with OCD in male patients, this result was not supported by studies in a Japanese population. The present association study assessed the risk for OCD conferred by this COMT polymorphism in a geographically different patient group, namely, the relatively genetically homogeneous Afrikaner population of South Africa. METHODS: Fifty-four unrelated OCD patients and fifty-four sex-matched controls were recruited from the same Afrikaner community. Patients and controls were phenotyped (DSM-IV) and genotyped for a NlaIII polymorphism with H (high activity) or L (low activity) alleles in the COMT gene. RESULTS: The H/L genotype was significantly more common than expected in the OCD patient group (P = 0.0017). LIMITATIONS: Replication studies with related individuals may be useful in discovering factors underpinning the H/L genotype abundance in the Afrikaner population. CONCLUSIONS: These results emphasise the need for further studies in genetically homogeneous populations to help define the complex etiology of this disease.","language":"eng","number":"1","journal":"Journal of Affective Disorders","author":[{"propositions":[],"lastnames":["Niehaus"],"firstnames":["D.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Kinnear"],"firstnames":["C.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Corfield"],"firstnames":["V.","A."],"suffixes":[]},{"propositions":["du"],"lastnames":["Toit"],"firstnames":["P.","L."],"suffixes":[]},{"propositions":["van"],"lastnames":["Kradenburg"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Moolman-Smook"],"firstnames":["J.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Weyers"],"firstnames":["J.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Potgieter"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Seedat"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Emsley"],"firstnames":["R.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Knowles"],"firstnames":["J.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Brink"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Stein"],"firstnames":["D.","J."],"suffixes":[]}],"month":"June","year":"2001","pmid":"11426511","note":"00063 ","keywords":"Adult, Alleles, Catechol O-Methyltransferase, Cross-Cultural Comparison, Female, Genetics, Population, Genotype, Humans, Male, Obsessive-Compulsive Disorder, Polymorphism, Genetic, South Africa","pages":"61–65","bibtex":"@article{niehaus_association_2001,\n\ttitle = {Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the {Afrikaner} population},\n\tvolume = {65},\n\tissn = {0165-0327},\n\tabstract = {BACKGROUND: It has been proposed that the catechol-o-methyl transferase gene (COMT) may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Whereas studies in a North American population showed that the low activity (L) allele of a functional polymorphism in COMT was associated with OCD in male patients, this result was not supported by studies in a Japanese population. The present association study assessed the risk for OCD conferred by this COMT polymorphism in a geographically different patient group, namely, the relatively genetically homogeneous Afrikaner population of South Africa.\nMETHODS: Fifty-four unrelated OCD patients and fifty-four sex-matched controls were recruited from the same Afrikaner community. Patients and controls were phenotyped (DSM-IV) and genotyped for a NlaIII polymorphism with H (high activity) or L (low activity) alleles in the COMT gene.\nRESULTS: The H/L genotype was significantly more common than expected in the OCD patient group (P = 0.0017).\nLIMITATIONS: Replication studies with related individuals may be useful in discovering factors underpinning the H/L genotype abundance in the Afrikaner population.\nCONCLUSIONS: These results emphasise the need for further studies in genetically homogeneous populations to help define the complex etiology of this disease.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Affective Disorders},\n\tauthor = {Niehaus, D. J. and Kinnear, C. J. and Corfield, V. A. and du Toit, P. L. and van Kradenburg, J. and Moolman-Smook, J. C. and Weyers, J. B. and Potgieter, A. and Seedat, S. and Emsley, R. A. and Knowles, J. A. and Brink, P. A. and Stein, D. 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