Omega-3 fatty acid and iron supplementation alone, but not in combination, lower inflammation and anemia of infection in Mycobacterium tuberculosis-infected mice. Nienaber, A., Baumgartner, J., Dolman, R. C, Ozturk, M., Zandberg, L., Hayford, F. E A, Brombacher, F., Blaauw, R., Parihar, S. P, Smuts, C. M, & Malan, L. Nutrients, 12(9):2897, Multidisciplinary Digital Publishing Institute, sep, 2020. ![Omega-3 fatty acid and iron supplementation alone, but not in combination, lower inflammation and anemia of infection in Mycobacterium tuberculosis-infected mice [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Progressive inflammation and anemia are common in tuberculosis (TB) and linked to poor clinical outcomes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have inflammation-resolving properties, whereas iron supplementation in TB may have limited efficacy and enhance bacterial growth. We investigated effects of iron and EPA/DHA supplementation, alone and in combination, on inflammation, anemia, iron status markers and clinical outcomes in Mycobacterium tuberculosis-infected C3HeB/FeJ mice. One week post-infection, mice received the AIN-93 diet without (control) or with supplemental iron (Fe), EPA/DHA, or Fe+EPA/DHA for 3 weeks. Mice supplemented with Fe or EPA/DHA had lower soluble transferrin receptor, ferritin and hepcidin than controls, but these effects were attenuated in Fe+EPA/DHA mice. EPA/DHA increased inflammation-resolving lipid mediators and lowered lung IL-1$α$, IFN-$γ$, plasma IL-1$β$, and TNF-$α$. Fe lowered lung IL-1$α$, IL-1$β$, plasma IL-1$β$, TNF-$α$, and IL-6. However, the cytokine-lowering effects in the lungs were attenuated with Fe+EPA/DHA. Mice supplemented with EPA/DHA had lower lung bacterial loads than controls, but this effect was attenuated in Fe+EPA/DHA mice. Thus, individually, post-infection EPA/DHA and iron supplementation lowered systemic and lung inflammation and mitigated anemia of infection in TB, but not when combined. EPA/DHA also enhanced bactericidal effects and could support inflammation resolution and management of anemia.
@article{Nienaber2020,
abstract = {Progressive inflammation and anemia are common in tuberculosis (TB) and linked to poor clinical outcomes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have inflammation-resolving properties, whereas iron supplementation in TB may have limited efficacy and enhance bacterial growth. We investigated effects of iron and EPA/DHA supplementation, alone and in combination, on inflammation, anemia, iron status markers and clinical outcomes in Mycobacterium tuberculosis-infected C3HeB/FeJ mice. One week post-infection, mice received the AIN-93 diet without (control) or with supplemental iron (Fe), EPA/DHA, or Fe+EPA/DHA for 3 weeks. Mice supplemented with Fe or EPA/DHA had lower soluble transferrin receptor, ferritin and hepcidin than controls, but these effects were attenuated in Fe+EPA/DHA mice. EPA/DHA increased inflammation-resolving lipid mediators and lowered lung IL-1$\alpha$, IFN-$\gamma$, plasma IL-1$\beta$, and TNF-$\alpha$. Fe lowered lung IL-1$\alpha$, IL-1$\beta$, plasma IL-1$\beta$, TNF-$\alpha$, and IL-6. However, the cytokine-lowering effects in the lungs were attenuated with Fe+EPA/DHA. Mice supplemented with EPA/DHA had lower lung bacterial loads than controls, but this effect was attenuated in Fe+EPA/DHA mice. Thus, individually, post-infection EPA/DHA and iron supplementation lowered systemic and lung inflammation and mitigated anemia of infection in TB, but not when combined. EPA/DHA also enhanced bactericidal effects and could support inflammation resolution and management of anemia.},
author = {Nienaber, Arista and Baumgartner, Jeannine and Dolman, Robin C and Ozturk, Mumin and Zandberg, Lizelle and Hayford, Frank E A and Brombacher, Frank and Blaauw, Renee and Parihar, Suraj P and Smuts, Cornelius M and Malan, Linda},
doi = {10.3390/nu12092897},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Nienaber et al. - 2020 - Omega-3 fatty acid and iron supplementation alone, but not in combination, lower inflammation and anemia of inf.pdf:pdf},
issn = {2072-6643},
journal = {Nutrients},
keywords = {OA,anemia of infection,docosahexaenoic acid,eicosapentaenoic acid,fund{\_}ack,inflammation,iron,original,tuberculosis},
mendeley-tags = {OA,fund{\_}ack,original},
month = {sep},
number = {9},
pages = {2897},
pmid = {32971969},
publisher = {Multidisciplinary Digital Publishing Institute},
title = {{Omega-3 fatty acid and iron supplementation alone, but not in combination, lower inflammation and anemia of infection in Mycobacterium tuberculosis-infected mice}},
url = {https://www.mdpi.com/2072-6643/12/9/2897},
volume = {12},
year = {2020}
}
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We investigated effects of iron and EPA/DHA supplementation, alone and in combination, on inflammation, anemia, iron status markers and clinical outcomes in Mycobacterium tuberculosis-infected C3HeB/FeJ mice. One week post-infection, mice received the AIN-93 diet without (control) or with supplemental iron (Fe), EPA/DHA, or Fe+EPA/DHA for 3 weeks. Mice supplemented with Fe or EPA/DHA had lower soluble transferrin receptor, ferritin and hepcidin than controls, but these effects were attenuated in Fe+EPA/DHA mice. EPA/DHA increased inflammation-resolving lipid mediators and lowered lung IL-1$α$, IFN-$γ$, plasma IL-1$β$, and TNF-$α$. Fe lowered lung IL-1$α$, IL-1$β$, plasma IL-1$β$, TNF-$α$, and IL-6. However, the cytokine-lowering effects in the lungs were attenuated with Fe+EPA/DHA. Mice supplemented with EPA/DHA had lower lung bacterial loads than controls, but this effect was attenuated in Fe+EPA/DHA mice. 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