@article{nierenberg_clinical_2005,
	title = {Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 {STEP}-{BD} participants},
	volume = {57},
	issn = {0006-3223},
	url = {http://dx.doi.org/10.1016/j.biopsych.2005.01.036},
	doi = {10.1016/j.biopsych.2005.01.036},
	abstract = {BACKGROUND: Systematic studies of children and adolescents with a
diagnosis of bipolar disorder show that rates of
attention-deficit/hyperactivity disorder (ADHD) range from 60\% to 90\%, but
the prevalence and implications of ADHD in adults with bipolar disorder
are less clear. METHODS: The first consecutive 1000 adults with bipolar
disorder enrolled in the National Institute of Mental Health's Systematic
Treatment Enhancement Program for Bipolar Disorder (STEP-BD) were assessed
for lifetime ADHD. The retrospective course of bipolar disorder, current
mood state, and prevalence of other comorbid psychiatric diagnoses were
compared for the groups with and without lifetime comorbid ADHD. RESULTS:
The overall lifetime prevalence of comorbid ADHD in this large cohort of
bipolar patients was 9.5\% (95\% confidence interval 7.6\%-11.4\%); 14.7\% of
male patients and 5.8\% of female patients with bipolar disorder had
lifetime ADHD. Patients with bipolar disorder and ADHD had the onset of
their mood disorder approximately 5 years earlier. After adjusting for age
of onset, those with ADHD comorbidity had shorter periods of wellness and
were more frequently depressed. We found that patients with bipolar
disorder comorbid with ADHD had a greater number of other comorbid
psychiatric diagnoses compared with those without comorbid ADHD, with
substantially higher rates of several anxiety disorders and alcohol and
substance abuse and dependence. CONCLUSIONS: Lifetime ADHD is a frequent
comorbid condition in adults with bipolar disorder, associated with a
worse course of bipolar disorder and greater burden of other psychiatric
comorbid conditions. Studies are needed that focus on the efficacy and
safety of treating ADHD comorbid with bipolar disorder.},
	number = {11},
	journal = {Biol. Psychiatry},
	author = {Nierenberg, Andrew A and Miyahara, Sachiko and Spencer, Tom and Wisniewski, Stephen R and Otto, Michael W and Simon, Naomi and Pollack, Mark H and Ostacher, Michael J and Yan, Leslie and Siegel, Rebecca and Sachs, Gary S and {STEP-BD Investigators}},
	month = jun,
	year = {2005},
	keywords = {Sep 20 import, duplicate},
	pages = {1467--1473}
}

{"_id":"5BM9B8StxcwQbcp2F","bibbaseid":"nierenberg-miyahara-spencer-wisniewski-otto-simon-pollack-ostacher-etal-clinicalanddiagnosticimplicationsoflifetimeattentiondeficithyperactivitydisordercomorbidityinadultswithbipolardisorderdatafromthefirst1000stepbdparticipants-2005","downloads":0,"creationDate":"2018-04-27T04:04:45.249Z","title":"Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants","author_short":["Nierenberg, A. A","Miyahara, S.","Spencer, T.","Wisniewski, S. R","Otto, M. W","Simon, N.","Pollack, M. H","Ostacher, M. J","Yan, L.","Siegel, R.","Sachs, G. S","STEP-BD Investigators"],"year":2005,"bibtype":"article","biburl":"https://bibbase.org/zotero/davidlloyd33","bibdata":{"bibtype":"article","type":"article","title":"Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants","volume":"57","issn":"0006-3223","url":"http://dx.doi.org/10.1016/j.biopsych.2005.01.036","doi":"10.1016/j.biopsych.2005.01.036","abstract":"BACKGROUND: Systematic studies of children and adolescents with a diagnosis of bipolar disorder show that rates of attention-deficit/hyperactivity disorder (ADHD) range from 60% to 90%, but the prevalence and implications of ADHD in adults with bipolar disorder are less clear. METHODS: The first consecutive 1000 adults with bipolar disorder enrolled in the National Institute of Mental Health's Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) were assessed for lifetime ADHD. The retrospective course of bipolar disorder, current mood state, and prevalence of other comorbid psychiatric diagnoses were compared for the groups with and without lifetime comorbid ADHD. RESULTS: The overall lifetime prevalence of comorbid ADHD in this large cohort of bipolar patients was 9.5% (95% confidence interval 7.6%-11.4%); 14.7% of male patients and 5.8% of female patients with bipolar disorder had lifetime ADHD. Patients with bipolar disorder and ADHD had the onset of their mood disorder approximately 5 years earlier. After adjusting for age of onset, those with ADHD comorbidity had shorter periods of wellness and were more frequently depressed. We found that patients with bipolar disorder comorbid with ADHD had a greater number of other comorbid psychiatric diagnoses compared with those without comorbid ADHD, with substantially higher rates of several anxiety disorders and alcohol and substance abuse and dependence. CONCLUSIONS: Lifetime ADHD is a frequent comorbid condition in adults with bipolar disorder, associated with a worse course of bipolar disorder and greater burden of other psychiatric comorbid conditions. Studies are needed that focus on the efficacy and safety of treating ADHD comorbid with bipolar disorder.","number":"11","journal":"Biol. Psychiatry","author":[{"propositions":[],"lastnames":["Nierenberg"],"firstnames":["Andrew","A"],"suffixes":[]},{"propositions":[],"lastnames":["Miyahara"],"firstnames":["Sachiko"],"suffixes":[]},{"propositions":[],"lastnames":["Spencer"],"firstnames":["Tom"],"suffixes":[]},{"propositions":[],"lastnames":["Wisniewski"],"firstnames":["Stephen","R"],"suffixes":[]},{"propositions":[],"lastnames":["Otto"],"firstnames":["Michael","W"],"suffixes":[]},{"propositions":[],"lastnames":["Simon"],"firstnames":["Naomi"],"suffixes":[]},{"propositions":[],"lastnames":["Pollack"],"firstnames":["Mark","H"],"suffixes":[]},{"propositions":[],"lastnames":["Ostacher"],"firstnames":["Michael","J"],"suffixes":[]},{"propositions":[],"lastnames":["Yan"],"firstnames":["Leslie"],"suffixes":[]},{"propositions":[],"lastnames":["Siegel"],"firstnames":["Rebecca"],"suffixes":[]},{"propositions":[],"lastnames":["Sachs"],"firstnames":["Gary","S"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["STEP-BD Investigators"],"suffixes":[]}],"month":"June","year":"2005","keywords":"Sep 20 import, duplicate","pages":"1467--1473","bibtex":"@article{nierenberg_clinical_2005,\n\ttitle = {Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 {STEP}-{BD} participants},\n\tvolume = {57},\n\tissn = {0006-3223},\n\turl = {http://dx.doi.org/10.1016/j.biopsych.2005.01.036},\n\tdoi = {10.1016/j.biopsych.2005.01.036},\n\tabstract = {BACKGROUND: Systematic studies of children and adolescents with a\ndiagnosis of bipolar disorder show that rates of\nattention-deficit/hyperactivity disorder (ADHD) range from 60\\% to 90\\%, but\nthe prevalence and implications of ADHD in adults with bipolar disorder\nare less clear. METHODS: The first consecutive 1000 adults with bipolar\ndisorder enrolled in the National Institute of Mental Health's Systematic\nTreatment Enhancement Program for Bipolar Disorder (STEP-BD) were assessed\nfor lifetime ADHD. The retrospective course of bipolar disorder, current\nmood state, and prevalence of other comorbid psychiatric diagnoses were\ncompared for the groups with and without lifetime comorbid ADHD. RESULTS:\nThe overall lifetime prevalence of comorbid ADHD in this large cohort of\nbipolar patients was 9.5\\% (95\\% confidence interval 7.6\\%-11.4\\%); 14.7\\% of\nmale patients and 5.8\\% of female patients with bipolar disorder had\nlifetime ADHD. Patients with bipolar disorder and ADHD had the onset of\ntheir mood disorder approximately 5 years earlier. After adjusting for age\nof onset, those with ADHD comorbidity had shorter periods of wellness and\nwere more frequently depressed. We found that patients with bipolar\ndisorder comorbid with ADHD had a greater number of other comorbid\npsychiatric diagnoses compared with those without comorbid ADHD, with\nsubstantially higher rates of several anxiety disorders and alcohol and\nsubstance abuse and dependence. CONCLUSIONS: Lifetime ADHD is a frequent\ncomorbid condition in adults with bipolar disorder, associated with a\nworse course of bipolar disorder and greater burden of other psychiatric\ncomorbid conditions. Studies are needed that focus on the efficacy and\nsafety of treating ADHD comorbid with bipolar disorder.},\n\tnumber = {11},\n\tjournal = {Biol. Psychiatry},\n\tauthor = {Nierenberg, Andrew A and Miyahara, Sachiko and Spencer, Tom and Wisniewski, Stephen R and Otto, Michael W and Simon, Naomi and Pollack, Mark H and Ostacher, Michael J and Yan, Leslie and Siegel, Rebecca and Sachs, Gary S and {STEP-BD Investigators}},\n\tmonth = jun,\n\tyear = {2005},\n\tkeywords = {Sep 20 import, duplicate},\n\tpages = {1467--1473}\n}\n\n","author_short":["Nierenberg, A. A","Miyahara, S.","Spencer, T.","Wisniewski, S. R","Otto, M. W","Simon, N.","Pollack, M. H","Ostacher, M. J","Yan, L.","Siegel, R.","Sachs, G. S","STEP-BD Investigators"],"key":"nierenberg_clinical_2005","id":"nierenberg_clinical_2005","bibbaseid":"nierenberg-miyahara-spencer-wisniewski-otto-simon-pollack-ostacher-etal-clinicalanddiagnosticimplicationsoflifetimeattentiondeficithyperactivitydisordercomorbidityinadultswithbipolardisorderdatafromthefirst1000stepbdparticipants-2005","role":"author","urls":{"Paper":"http://dx.doi.org/10.1016/j.biopsych.2005.01.036"},"keyword":["Sep 20 import","duplicate"],"downloads":0},"search_terms":["clinical","diagnostic","implications","lifetime","attention","deficit","hyperactivity","disorder","comorbidity","adults","bipolar","disorder","data","first","1000","step","participants","nierenberg","miyahara","spencer","wisniewski","otto","simon","pollack","ostacher","yan","siegel","sachs","step-bd investigators"],"keywords":["sep 20 import","duplicate"],"authorIDs":[],"dataSources":["pWG6kkFjeQheTxKbs"]}