Motor behavior activates Bergmann glial networks. Nimmerjahn, A., Mukamel, E. A., & Schnitzer, M. J. Neuron, 62(3):400–12, May, 2009. Publisher: Elsevier Ltd ISBN: 0896-6273![Motor behavior activates Bergmann glial networks. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Although it is firmly established that neuronal activity is a prime determinant of animal behavior, relationships between astrocytic excitation and animal behavior have remained opaque. Cerebellar Bergmann glia are radial astrocytes that are implicated in motor behavior and exhibit Ca(2+) excitation. However, Ca(2+) excitation in these cells has not previously been studied in behaving animals. Using two-photon microscopy we found that Bergmann glia exhibit three forms of Ca(2+) excitation in awake, behaving mice. Two of these are ongoing within the cerebellar vermis. During locomotor performance concerted Ca(2+) excitation arises in networks of at least hundreds of Bergmann glia extending across several hundred microns or more. Concerted Ca(2+) excitation was abolished by anesthesia or blockade of either neural activity or glutamatergic transmission. Thus, large networks of Bergmann glia can be activated by specific animal behaviors and undergo excitation of sufficient magnitude to potentially initiate macroscopic changes in brain dynamics or blood flow.
@article{Nimmerjahn2009,
title = {Motor behavior activates {Bergmann} glial networks.},
volume = {62},
issn = {1097-4199},
url = {http://linkinghub.elsevier.com/retrieve/pii/S089662730900244X},
doi = {10.1016/j.neuron.2009.03.019},
abstract = {Although it is firmly established that neuronal activity is a prime determinant of animal behavior, relationships between astrocytic excitation and animal behavior have remained opaque. Cerebellar Bergmann glia are radial astrocytes that are implicated in motor behavior and exhibit Ca(2+) excitation. However, Ca(2+) excitation in these cells has not previously been studied in behaving animals. Using two-photon microscopy we found that Bergmann glia exhibit three forms of Ca(2+) excitation in awake, behaving mice. Two of these are ongoing within the cerebellar vermis. During locomotor performance concerted Ca(2+) excitation arises in networks of at least hundreds of Bergmann glia extending across several hundred microns or more. Concerted Ca(2+) excitation was abolished by anesthesia or blockade of either neural activity or glutamatergic transmission. Thus, large networks of Bergmann glia can be activated by specific animal behaviors and undergo excitation of sufficient magnitude to potentially initiate macroscopic changes in brain dynamics or blood flow.},
number = {3},
urldate = {2012-07-31},
journal = {Neuron},
author = {Nimmerjahn, Axel and Mukamel, Eran A. and Schnitzer, Mark J.},
month = may,
year = {2009},
pmid = {19447095},
note = {Publisher: Elsevier Ltd
ISBN: 0896-6273},
keywords = {Animals, Astrocytes, Astrocytes: physiology, CELLBIO, Calcium Signaling, Calcium Signaling: physiology, Cell Communication, Cell Communication: physiology, Cerebellum, Cerebellum: cytology, Cerebellum: physiology, Inbred C57BL, MOLNEURO, Male, Membrane Potentials, Membrane Potentials: physiology, Mice, Motor Activity, Motor Activity: physiology, Motor Skills, Motor Skills: physiology, SYSNEURO, glia},
pages = {400--12},
}
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