@ARTICLE{Noctor2007-ty,
  title    = "Neural stem and progenitor cells in cortical development",
  author   = "Noctor, Stephen C and Martinez-Cerde{\~n}o, Veronica and
              Kriegstein, Arnold R",
  abstract = "Recent work has begun to identify neural stem and progenitor
              cells in the embryonic and adult brain, and is unravelling the
              mechanisms whereby new nerve cells are created and delivered to
              their correct locations. Radial glial (RG) cells, which are
              present in the developing mammalian brain, have been proposed to
              be neural stem cells because they produce multiple cell types.
              Furthermore, time-lapse imaging demonstrates that RG cells
              undergo asymmetric self-renewing divisions to produce immature
              neurons that migrate along their parent radial fibre to reach the
              developing cerebral cortex. RG cells also produce intermediate
              progenitor (IP) cells that undergo symmetric division in the
              subventricular zone of the embryonic cortex to produce pairs of
              neurons. The symmetric IP divisions increase cell number within
              the same cortical layer. This two-step process of neurogenesis
              suggests new mechanisms for the generation of cell diversity and
              cell number in the developing cortex and supports a model similar
              to that proposed for the development of the fruit fly CNS. In
              this model, a temporal sequence of gene expression changes in
              asymmetrically dividing self-renewed RG cells could lead to the
              differential inheritance of cell identity genes in cortical cells
              generated at different cell cycles.",
  journal  = "Novartis Found Symp",
  volume   =  288,
  pages    = "59--73; discussion 73--8, 96--8",
  year     =  2007,
  address  = "England",
  language = "en"
}

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