Contribution of intermediate progenitor cells to cortical histogenesis. Noctor, S. C, Martı́nez-Cerdeño, Verónica, & Kriegstein, A. R Arch Neurol, 64(5):639–642, United States, May, 2007.
abstract   bibtex   
The mammalian cerebral cortex is the most cellularly complex structure in the animal kingdom. Almost all cortical neurons are produced during a limited embryonic period by cortical progenitor cells in a proliferative region that surrounds the ventricular system of the developing brain. The proliferative region comprises 2 distinct zones, the ventricular zone, which is a neuroepithelial layer directly adjacent to the ventricular lumen, and the subventricular zone, which is positioned superficial to the ventricular zone. Recent advances in molecular and cell biology have made possible the study of specific cell populations, and 2 cortical progenitor cell types, radial glial cells in the ventricular zone and intermediate progenitor cells in the subventricular zone, have been shown to generate neurons in the embryonic cerebral cortex. These findings have refined our understanding of cortical neurogenesis, with implications for understanding the causes of neurodevelopmental disorders and for their potential treatment.
@ARTICLE{Noctor2007-wh,
  title    = "Contribution of intermediate progenitor cells to cortical
              histogenesis",
  author   = "Noctor, Stephen C and Mart{\'\i}nez-Cerde{\~n}o, Ver{\'o}nica and
              Kriegstein, Arnold R",
  abstract = "The mammalian cerebral cortex is the most cellularly complex
              structure in the animal kingdom. Almost all cortical neurons are
              produced during a limited embryonic period by cortical progenitor
              cells in a proliferative region that surrounds the ventricular
              system of the developing brain. The proliferative region
              comprises 2 distinct zones, the ventricular zone, which is a
              neuroepithelial layer directly adjacent to the ventricular lumen,
              and the subventricular zone, which is positioned superficial to
              the ventricular zone. Recent advances in molecular and cell
              biology have made possible the study of specific cell
              populations, and 2 cortical progenitor cell types, radial glial
              cells in the ventricular zone and intermediate progenitor cells
              in the subventricular zone, have been shown to generate neurons
              in the embryonic cerebral cortex. These findings have refined our
              understanding of cortical neurogenesis, with implications for
              understanding the causes of neurodevelopmental disorders and for
              their potential treatment.",
  journal  = "Arch Neurol",
  volume   =  64,
  number   =  5,
  pages    = "639--642",
  month    =  may,
  year     =  2007,
  address  = "United States",
  language = "en"
}

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