@ARTICLE{Noctor2008-ot,
  title    = "Distinct behaviors of neural stem and progenitor cells underlie
              cortical neurogenesis",
  author   = "Noctor, Stephen C and Mart{\'\i}nez-Cerde{\~n}o, Ver{\'o}nica and
              Kriegstein, Arnold R",
  abstract = "Neocortical precursor cells undergo symmetric and asymmetric
              divisions while producing large numbers of diverse cortical cell
              types. In Drosophila, cleavage plane orientation dictates the
              inheritance of fate-determinants and the symmetry of newborn
              daughter cells during neuroblast cell divisions. One model for
              predicting daughter cell fate in the mammalian neocortex is also
              based on cleavage plane orientation. Precursor cell divisions
              with a cleavage plane orientation that is perpendicular with
              respect to the ventricular surface (vertical) are predicted to be
              symmetric, while divisions with a cleavage plane orientation that
              is parallel to the surface (horizontal) are predicted to be
              asymmetric neurogenic divisions. However, analysis of cleavage
              plane orientation at the ventricle suggests that the number of
              predicted neurogenic divisions might be insufficient to produce
              large amounts of cortical neurons. To understand factors that
              correlate with the symmetry of cell divisions, we examined rat
              neocortical precursor cells in situ through real-time imaging,
              marker analysis, and electrophysiological recordings. We find
              that cleavage plane orientation is more closely associated with
              precursor cell type than with daughter cell fate, as commonly
              thought. Radial glia cells in the VZ primarily divide with a
              vertical orientation throughout cortical development and undergo
              symmetric or asymmetric self-renewing divisions depending on the
              stage of development. In contrast, most intermediate progenitor
              cells divide in the subventricular zone with a horizontal
              orientation and produce symmetric daughter cells. We propose a
              model for predicting daughter cell fate that considers precursor
              cell type, stage of development, and the planar segregation of
              fate determinants.",
  journal  = "J Comp Neurol",
  volume   =  508,
  number   =  1,
  pages    = "28--44",
  month    =  may,
  year     =  2008,
  language = "en"
}

{"_id":"A7oa6DAm5KhA9cjbp","bibbaseid":"noctor-martnezcerdeo-kriegstein-distinctbehaviorsofneuralstemandprogenitorcellsunderliecorticalneurogenesis-2008","author_short":["Noctor, S. C","Martı́nez-Cerdeño, Verónica","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis","author":[{"propositions":[],"lastnames":["Noctor"],"firstnames":["Stephen","C"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Martı́nez-Cerdeño, Verónica"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Neocortical precursor cells undergo symmetric and asymmetric divisions while producing large numbers of diverse cortical cell types. In Drosophila, cleavage plane orientation dictates the inheritance of fate-determinants and the symmetry of newborn daughter cells during neuroblast cell divisions. One model for predicting daughter cell fate in the mammalian neocortex is also based on cleavage plane orientation. Precursor cell divisions with a cleavage plane orientation that is perpendicular with respect to the ventricular surface (vertical) are predicted to be symmetric, while divisions with a cleavage plane orientation that is parallel to the surface (horizontal) are predicted to be asymmetric neurogenic divisions. However, analysis of cleavage plane orientation at the ventricle suggests that the number of predicted neurogenic divisions might be insufficient to produce large amounts of cortical neurons. To understand factors that correlate with the symmetry of cell divisions, we examined rat neocortical precursor cells in situ through real-time imaging, marker analysis, and electrophysiological recordings. We find that cleavage plane orientation is more closely associated with precursor cell type than with daughter cell fate, as commonly thought. Radial glia cells in the VZ primarily divide with a vertical orientation throughout cortical development and undergo symmetric or asymmetric self-renewing divisions depending on the stage of development. In contrast, most intermediate progenitor cells divide in the subventricular zone with a horizontal orientation and produce symmetric daughter cells. We propose a model for predicting daughter cell fate that considers precursor cell type, stage of development, and the planar segregation of fate determinants.","journal":"J Comp Neurol","volume":"508","number":"1","pages":"28–44","month":"May","year":"2008","language":"en","bibtex":"@ARTICLE{Noctor2008-ot,\n title = \"Distinct behaviors of neural stem and progenitor cells underlie\n cortical neurogenesis\",\n author = \"Noctor, Stephen C and Mart{\\'\\i}nez-Cerde{\\~n}o, Ver{\\'o}nica and\n Kriegstein, Arnold R\",\n abstract = \"Neocortical precursor cells undergo symmetric and asymmetric\n divisions while producing large numbers of diverse cortical cell\n types. In Drosophila, cleavage plane orientation dictates the\n inheritance of fate-determinants and the symmetry of newborn\n daughter cells during neuroblast cell divisions. One model for\n predicting daughter cell fate in the mammalian neocortex is also\n based on cleavage plane orientation. Precursor cell divisions\n with a cleavage plane orientation that is perpendicular with\n respect to the ventricular surface (vertical) are predicted to be\n symmetric, while divisions with a cleavage plane orientation that\n is parallel to the surface (horizontal) are predicted to be\n asymmetric neurogenic divisions. However, analysis of cleavage\n plane orientation at the ventricle suggests that the number of\n predicted neurogenic divisions might be insufficient to produce\n large amounts of cortical neurons. To understand factors that\n correlate with the symmetry of cell divisions, we examined rat\n neocortical precursor cells in situ through real-time imaging,\n marker analysis, and electrophysiological recordings. We find\n that cleavage plane orientation is more closely associated with\n precursor cell type than with daughter cell fate, as commonly\n thought. Radial glia cells in the VZ primarily divide with a\n vertical orientation throughout cortical development and undergo\n symmetric or asymmetric self-renewing divisions depending on the\n stage of development. In contrast, most intermediate progenitor\n cells divide in the subventricular zone with a horizontal\n orientation and produce symmetric daughter cells. We propose a\n model for predicting daughter cell fate that considers precursor\n cell type, stage of development, and the planar segregation of\n fate determinants.\",\n journal = \"J Comp Neurol\",\n volume = 508,\n number = 1,\n pages = \"28--44\",\n month = may,\n year = 2008,\n language = \"en\"\n}\n\n","author_short":["Noctor, S. C","Martı́nez-Cerdeño, Verónica","Kriegstein, A. R"],"key":"Noctor2008-ot","id":"Noctor2008-ot","bibbaseid":"noctor-martnezcerdeo-kriegstein-distinctbehaviorsofneuralstemandprogenitorcellsunderliecorticalneurogenesis-2008","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["distinct","behaviors","neural","stem","progenitor","cells","underlie","cortical","neurogenesis","noctor","martı́nez-cerdeño","kriegstein"],"title":"Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis","year":2008}