Piecewise smooth hybrid systems as models for networks in molecular biology. Noel, V., Vakulenko, S., & Radulescu, O.
abstract   bibtex   
We discuss piecewise smooth hybrid systems as models for regulatory networks in molecular biology. These systems involve both continuous and discrete variables. In the context of gene networks, the discrete variables allow to switch on and off some of the molecular interactions in the model of the biological system. Piecewise smooth hybrid models are well adapted to approximate the dynamics of multiscale dissipative systems that occur in molecular biology. We show how to produce such models by a top down approach that use biological knowledge for a guided choice of important variables and interactions. Then we propose an algorithm for fitting parameters of the piecewise smooth models from data. We illustrate some of the possibilities of this approach by proposing a minimal piecewise smooth model for the cell cycle.
@article{noel_piecewise_nodate,
	title = {Piecewise smooth hybrid systems as models for networks in molecular biology},
	copyright = {All rights reserved},
	abstract = {We discuss piecewise smooth hybrid systems as models for regulatory networks in molecular biology. These systems involve both continuous and discrete variables. In the context of gene networks, the discrete variables allow to switch on and off some of the molecular interactions in the model of the biological system. Piecewise smooth hybrid models are well adapted to approximate the dynamics of multiscale dissipative systems that occur in molecular biology. We show how to produce such models by a top down approach that use biological knowledge for a guided choice of important variables and interactions. Then we propose an algorithm for fitting parameters of the piecewise smooth models from data. We illustrate some of the possibilities of this approach by proposing a minimal piecewise smooth model for the cell cycle.},
	language = {en},
	author = {Noel, Vincent and Vakulenko, Sergei and Radulescu, Ovidiu},
	pages = {6}
}
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