TonB-dependent transporters: regulation, structure, and function. Noinaj, N., Guillier, M., Barnard, T. J, & Buchanan, S. K Annual Review of Microbiology, April, 2010. ![TonB-dependent transporters: regulation, structure, and function [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and transport ferric chelates, called siderophores, as well as vitamin B(12), nickel complexes, and carbohydrates. The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane. The siderophore substrates range in complexity from simple small molecules such as citrate to large proteins such as serum transferrin and hemoglobin. Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-dependent regulators, sigma/anti-sigma factor systems, small RNAs, and even a riboswitch. In recent years, many new structures of TBDTs have been solved in various states, resulting in a more complete understanding of siderophore selectivity and binding, signal transduction across the outer membrane, and interaction with the TonB-ExbB-ExbD complex. However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered. Expected final online publication date for the Annual Review of Microbiology Volume 64 is September 08, 2010. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
@article{noinaj_tonb-dependent_2010,
title = {{TonB}-dependent transporters: regulation, structure, and function},
issn = {1545-3251},
shorttitle = {{TonB}-{Dependent} {Transporters}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20420522},
doi = {10.1146/annurev.micro.112408.134247},
abstract = {TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and transport ferric chelates, called siderophores, as well as vitamin B(12), nickel complexes, and carbohydrates. The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane. The siderophore substrates range in complexity from simple small molecules such as citrate to large proteins such as serum transferrin and hemoglobin. Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-dependent regulators, sigma/anti-sigma factor systems, small RNAs, and even a riboswitch. In recent years, many new structures of TBDTs have been solved in various states, resulting in a more complete understanding of siderophore selectivity and binding, signal transduction across the outer membrane, and interaction with the TonB-ExbB-ExbD complex. However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered. Expected final online publication date for the Annual Review of Microbiology Volume 64 is September 08, 2010. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.},
urldate = {2010-05-14TZ},
journal = {Annual Review of Microbiology},
author = {Noinaj, Nicholas and Guillier, Maude and Barnard, Travis J and Buchanan, Susan K},
month = apr,
year = {2010},
pmid = {20420522}
}
Downloads: 0
{"_id":"sKXrvga4B4MsfW9Ta","bibbaseid":"noinaj-guillier-barnard-buchanan-tonbdependenttransportersregulationstructureandfunction-2010","downloads":0,"creationDate":"2017-04-04T08:13:35.654Z","title":"TonB-dependent transporters: regulation, structure, and function","author_short":["Noinaj, N.","Guillier, M.","Barnard, T. J","Buchanan, S. K"],"year":2010,"bibtype":"article","biburl":"http://bibbase.org/zotero/velocityhughes","bibdata":{"bibtype":"article","type":"article","title":"TonB-dependent transporters: regulation, structure, and function","issn":"1545-3251","shorttitle":"TonB-Dependent Transporters","url":"http://www.ncbi.nlm.nih.gov/pubmed/20420522","doi":"10.1146/annurev.micro.112408.134247","abstract":"TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and transport ferric chelates, called siderophores, as well as vitamin B(12), nickel complexes, and carbohydrates. The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane. The siderophore substrates range in complexity from simple small molecules such as citrate to large proteins such as serum transferrin and hemoglobin. Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-dependent regulators, sigma/anti-sigma factor systems, small RNAs, and even a riboswitch. In recent years, many new structures of TBDTs have been solved in various states, resulting in a more complete understanding of siderophore selectivity and binding, signal transduction across the outer membrane, and interaction with the TonB-ExbB-ExbD complex. However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered. Expected final online publication date for the Annual Review of Microbiology Volume 64 is September 08, 2010. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.","urldate":"2010-05-14TZ","journal":"Annual Review of Microbiology","author":[{"propositions":[],"lastnames":["Noinaj"],"firstnames":["Nicholas"],"suffixes":[]},{"propositions":[],"lastnames":["Guillier"],"firstnames":["Maude"],"suffixes":[]},{"propositions":[],"lastnames":["Barnard"],"firstnames":["Travis","J"],"suffixes":[]},{"propositions":[],"lastnames":["Buchanan"],"firstnames":["Susan","K"],"suffixes":[]}],"month":"April","year":"2010","pmid":"20420522","bibtex":"@article{noinaj_tonb-dependent_2010,\n\ttitle = {{TonB}-dependent transporters: regulation, structure, and function},\n\tissn = {1545-3251},\n\tshorttitle = {{TonB}-{Dependent} {Transporters}},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/20420522},\n\tdoi = {10.1146/annurev.micro.112408.134247},\n\tabstract = {TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and transport ferric chelates, called siderophores, as well as vitamin B(12), nickel complexes, and carbohydrates. The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane. The siderophore substrates range in complexity from simple small molecules such as citrate to large proteins such as serum transferrin and hemoglobin. Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-dependent regulators, sigma/anti-sigma factor systems, small RNAs, and even a riboswitch. In recent years, many new structures of TBDTs have been solved in various states, resulting in a more complete understanding of siderophore selectivity and binding, signal transduction across the outer membrane, and interaction with the TonB-ExbB-ExbD complex. However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered. Expected final online publication date for the Annual Review of Microbiology Volume 64 is September 08, 2010. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.},\n\turldate = {2010-05-14TZ},\n\tjournal = {Annual Review of Microbiology},\n\tauthor = {Noinaj, Nicholas and Guillier, Maude and Barnard, Travis J and Buchanan, Susan K},\n\tmonth = apr,\n\tyear = {2010},\n\tpmid = {20420522}\n}\n\n","author_short":["Noinaj, N.","Guillier, M.","Barnard, T. J","Buchanan, S. K"],"key":"noinaj_tonb-dependent_2010","id":"noinaj_tonb-dependent_2010","bibbaseid":"noinaj-guillier-barnard-buchanan-tonbdependenttransportersregulationstructureandfunction-2010","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/20420522"},"downloads":0},"search_terms":["tonb","dependent","transporters","regulation","structure","function","noinaj","guillier","barnard","buchanan"],"keywords":[],"authorIDs":[],"dataSources":["QQyXj7M8pdnbq89aP"]}