@ARTICLE{Nowakowski2018-ma,
  title    = "Regulation of cell-type-specific transcriptomes by {microRNA}
              networks during human brain development",
  author   = "Nowakowski, Tomasz J and Rani, Neha and Golkaram, Mahdi and Zhou,
              Hongjun R and Alvarado, Beatriz and Huch, Kylie and West, Jay A
              and Leyrat, Anne and Pollen, Alex A and Kriegstein, Arnold R and
              Petzold, Linda R and Kosik, Kenneth S",
  abstract = "MicroRNAs (miRNAs) regulate many cellular events during brain
              development by interacting with hundreds of mRNA transcripts.
              However, miRNAs operate nonuniformly upon the transcriptional
              profile with an as yet unknown logic. Shortcomings in defining
              miRNA-mRNA networks include limited knowledge of in vivo miRNA
              targets and their abundance in single cells. By combining
              multiple complementary approaches, high-throughput sequencing of
              RNA isolated by cross-linking immunoprecipitation with an
              antibody to AGO2 (AGO2-HITS-CLIP), single-cell profiling and
              computational analyses using bipartite and coexpression networks,
              we show that miRNA-mRNA interactions operate as functional
              modules that often correspond to cell-type identities and undergo
              dynamic transitions during brain development. These networks are
              highly dynamic during development and over the course of
              evolution. One such interaction is between radial-glia-enriched
              ORC4 and miR-2115, a great-ape-specific miRNA, which appears to
              control radial glia proliferation rates during human brain
              development.",
  journal  = "Nat Neurosci",
  volume   =  21,
  number   =  12,
  pages    = "1784--1792",
  month    =  nov,
  year     =  2018,
  language = "en"
}

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S"],"bibdata":{"bibtype":"article","type":"article","title":"Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development","author":[{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","J"],"suffixes":[]},{"propositions":[],"lastnames":["Rani"],"firstnames":["Neha"],"suffixes":[]},{"propositions":[],"lastnames":["Golkaram"],"firstnames":["Mahdi"],"suffixes":[]},{"propositions":[],"lastnames":["Zhou"],"firstnames":["Hongjun","R"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarado"],"firstnames":["Beatriz"],"suffixes":[]},{"propositions":[],"lastnames":["Huch"],"firstnames":["Kylie"],"suffixes":[]},{"propositions":[],"lastnames":["West"],"firstnames":["Jay","A"],"suffixes":[]},{"propositions":[],"lastnames":["Leyrat"],"firstnames":["Anne"],"suffixes":[]},{"propositions":[],"lastnames":["Pollen"],"firstnames":["Alex","A"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Petzold"],"firstnames":["Linda","R"],"suffixes":[]},{"propositions":[],"lastnames":["Kosik"],"firstnames":["Kenneth","S"],"suffixes":[]}],"abstract":"MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting with hundreds of mRNA transcripts. However, miRNAs operate nonuniformly upon the transcriptional profile with an as yet unknown logic. Shortcomings in defining miRNA-mRNA networks include limited knowledge of in vivo miRNA targets and their abundance in single cells. By combining multiple complementary approaches, high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation with an antibody to AGO2 (AGO2-HITS-CLIP), single-cell profiling and computational analyses using bipartite and coexpression networks, we show that miRNA-mRNA interactions operate as functional modules that often correspond to cell-type identities and undergo dynamic transitions during brain development. These networks are highly dynamic during development and over the course of evolution. One such interaction is between radial-glia-enriched ORC4 and miR-2115, a great-ape-specific miRNA, which appears to control radial glia proliferation rates during human brain development.","journal":"Nat Neurosci","volume":"21","number":"12","pages":"1784–1792","month":"November","year":"2018","language":"en","bibtex":"@ARTICLE{Nowakowski2018-ma,\n title = \"Regulation of cell-type-specific transcriptomes by {microRNA}\n networks during human brain development\",\n author = \"Nowakowski, Tomasz J and Rani, Neha and Golkaram, Mahdi and Zhou,\n Hongjun R and Alvarado, Beatriz and Huch, Kylie and West, Jay A\n and Leyrat, Anne and Pollen, Alex A and Kriegstein, Arnold R and\n Petzold, Linda R and Kosik, Kenneth S\",\n abstract = \"MicroRNAs (miRNAs) regulate many cellular events during brain\n development by interacting with hundreds of mRNA transcripts.\n However, miRNAs operate nonuniformly upon the transcriptional\n profile with an as yet unknown logic. Shortcomings in defining\n miRNA-mRNA networks include limited knowledge of in vivo miRNA\n targets and their abundance in single cells. By combining\n multiple complementary approaches, high-throughput sequencing of\n RNA isolated by cross-linking immunoprecipitation with an\n antibody to AGO2 (AGO2-HITS-CLIP), single-cell profiling and\n computational analyses using bipartite and coexpression networks,\n we show that miRNA-mRNA interactions operate as functional\n modules that often correspond to cell-type identities and undergo\n dynamic transitions during brain development. These networks are\n highly dynamic during development and over the course of\n evolution. One such interaction is between radial-glia-enriched\n ORC4 and miR-2115, a great-ape-specific miRNA, which appears to\n control radial glia proliferation rates during human brain\n development.\",\n journal = \"Nat Neurosci\",\n volume = 21,\n number = 12,\n pages = \"1784--1792\",\n month = nov,\n year = 2018,\n language = \"en\"\n}\n\n","author_short":["Nowakowski, T. J","Rani, N.","Golkaram, M.","Zhou, H. R","Alvarado, B.","Huch, K.","West, J. A","Leyrat, A.","Pollen, A. A","Kriegstein, A. R","Petzold, L. R","Kosik, K. S"],"key":"Nowakowski2018-ma","id":"Nowakowski2018-ma","bibbaseid":"nowakowski-rani-golkaram-zhou-alvarado-huch-west-leyrat-etal-regulationofcelltypespecifictranscriptomesbymicrornanetworksduringhumanbraindevelopment-2018","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["regulation","cell","type","specific","transcriptomes","microrna","networks","during","human","brain","development","nowakowski","rani","golkaram","zhou","alvarado","huch","west","leyrat","pollen","kriegstein","petzold","kosik"],"title":"Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development","year":2018}