Physcomitrium patens PpRIC, an ancestral CRIB-domain ROP effector, inhibits auxin-induced differentiation of apical initial cells. Ntefidou, M., Eklund, D. M., Bail, A. L., Schulmeister, S., Scherbel, F., Brandl, L., Dörfler, W., Eichstädt, C., Bannmüller, A., Ljung, K., & Kost, B. Cell Reports, February, 2023. Publisher: Elsevier![Physcomitrium patens PpRIC, an ancestral CRIB-domain ROP effector, inhibits auxin-induced differentiation of apical initial cells [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex RHO guanosine triphosphatases are important eukaryotic regulators of cell differentiation and behavior. Plant ROP (RHO of plant) family members activate specific, incompletely characterized downstream signaling. The structurally simple land plant Physcomitrium patens is missing homologs of key animal and flowering plant RHO effectors but contains a single CRIB (CDC42/RAC interactive binding)-domain-containing RIC (ROP-interacting CRIB-containing) protein (PpRIC). Protonemal P. patens filaments elongate based on regular division and PpROP-dependent tip growth of apical initial cells, which upon stimulation by the hormone auxin differentiate caulonemal characteristics. PpRIC interacts with active PpROP1, co-localizes with this protein at the plasma membrane at the tip of apical initial cells, and accumulates in the nucleus. Remarkably, PpRIC is not required for tip growth but is targeted to the nucleus to block caulonema differentiation downstream of auxin-controlled gene expression. These observations establish functions of PpRIC in mediating crosstalk between ROP and auxin signaling, which contributes to the maintenance of apical initial cell identity.
@article{ntefidou_physcomitrium_2023,
title = {Physcomitrium patens {PpRIC}, an ancestral {CRIB}-domain {ROP} effector, inhibits auxin-induced differentiation of apical initial cells},
volume = {42},
issn = {2211-1247},
url = {https://www.cell.com/cell-reports/abstract/S2211-1247(23)00141-9},
doi = {10.1016/j.celrep.2023.112130},
abstract = {RHO guanosine triphosphatases are important eukaryotic regulators of cell differentiation and behavior. Plant ROP (RHO of plant) family members activate specific, incompletely characterized downstream signaling. The structurally simple land plant Physcomitrium patens is missing homologs of key animal and flowering plant RHO effectors but contains a single CRIB (CDC42/RAC interactive binding)-domain-containing RIC (ROP-interacting CRIB-containing) protein (PpRIC). Protonemal P. patens filaments elongate based on regular division and PpROP-dependent tip growth of apical initial cells, which upon stimulation by the hormone auxin differentiate caulonemal characteristics. PpRIC interacts with active PpROP1, co-localizes with this protein at the plasma membrane at the tip of apical initial cells, and accumulates in the nucleus. Remarkably, PpRIC is not required for tip growth but is targeted to the nucleus to block caulonema differentiation downstream of auxin-controlled gene expression. These observations establish functions of PpRIC in mediating crosstalk between ROP and auxin signaling, which contributes to the maintenance of apical initial cell identity.},
language = {English},
number = {2},
urldate = {2023-02-23},
journal = {Cell Reports},
author = {Ntefidou, Maria and Eklund, D. Magnus and Bail, Aude Le and Schulmeister, Sylwia and Scherbel, Franziska and Brandl, Lisa and Dörfler, Wolfgang and Eichstädt, Chantal and Bannmüller, Anna and Ljung, Karin and Kost, Benedikt},
month = feb,
year = {2023},
pmid = {36790931},
note = {Publisher: Elsevier},
keywords = {CP: Developmental biology, CP: Plants, CRIB domain, Physcomitrium patens, RHO/ROP GTPases, RHO/ROP effectors, auxin, cell differentiation, initial cells, land plant evolution, nuclear targeting, tip growth},
}
Downloads: 0
{"_id":"d58dcrh3AiEyK7uqj","bibbaseid":"ntefidou-eklund-bail-schulmeister-scherbel-brandl-drfler-eichstdt-etal-physcomitriumpatensppricanancestralcribdomainropeffectorinhibitsauxininduceddifferentiationofapicalinitialcells-2023","author_short":["Ntefidou, M.","Eklund, D. M.","Bail, A. L.","Schulmeister, S.","Scherbel, F.","Brandl, L.","Dörfler, W.","Eichstädt, C.","Bannmüller, A.","Ljung, K.","Kost, B."],"bibdata":{"bibtype":"article","type":"article","title":"Physcomitrium patens PpRIC, an ancestral CRIB-domain ROP effector, inhibits auxin-induced differentiation of apical initial cells","volume":"42","issn":"2211-1247","url":"https://www.cell.com/cell-reports/abstract/S2211-1247(23)00141-9","doi":"10.1016/j.celrep.2023.112130","abstract":"RHO guanosine triphosphatases are important eukaryotic regulators of cell differentiation and behavior. Plant ROP (RHO of plant) family members activate specific, incompletely characterized downstream signaling. The structurally simple land plant Physcomitrium patens is missing homologs of key animal and flowering plant RHO effectors but contains a single CRIB (CDC42/RAC interactive binding)-domain-containing RIC (ROP-interacting CRIB-containing) protein (PpRIC). Protonemal P. patens filaments elongate based on regular division and PpROP-dependent tip growth of apical initial cells, which upon stimulation by the hormone auxin differentiate caulonemal characteristics. PpRIC interacts with active PpROP1, co-localizes with this protein at the plasma membrane at the tip of apical initial cells, and accumulates in the nucleus. Remarkably, PpRIC is not required for tip growth but is targeted to the nucleus to block caulonema differentiation downstream of auxin-controlled gene expression. These observations establish functions of PpRIC in mediating crosstalk between ROP and auxin signaling, which contributes to the maintenance of apical initial cell identity.","language":"English","number":"2","urldate":"2023-02-23","journal":"Cell Reports","author":[{"propositions":[],"lastnames":["Ntefidou"],"firstnames":["Maria"],"suffixes":[]},{"propositions":[],"lastnames":["Eklund"],"firstnames":["D.","Magnus"],"suffixes":[]},{"propositions":[],"lastnames":["Bail"],"firstnames":["Aude","Le"],"suffixes":[]},{"propositions":[],"lastnames":["Schulmeister"],"firstnames":["Sylwia"],"suffixes":[]},{"propositions":[],"lastnames":["Scherbel"],"firstnames":["Franziska"],"suffixes":[]},{"propositions":[],"lastnames":["Brandl"],"firstnames":["Lisa"],"suffixes":[]},{"propositions":[],"lastnames":["Dörfler"],"firstnames":["Wolfgang"],"suffixes":[]},{"propositions":[],"lastnames":["Eichstädt"],"firstnames":["Chantal"],"suffixes":[]},{"propositions":[],"lastnames":["Bannmüller"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Ljung"],"firstnames":["Karin"],"suffixes":[]},{"propositions":[],"lastnames":["Kost"],"firstnames":["Benedikt"],"suffixes":[]}],"month":"February","year":"2023","pmid":"36790931","note":"Publisher: Elsevier","keywords":"CP: Developmental biology, CP: Plants, CRIB domain, Physcomitrium patens, RHO/ROP GTPases, RHO/ROP effectors, auxin, cell differentiation, initial cells, land plant evolution, nuclear targeting, tip growth","bibtex":"@article{ntefidou_physcomitrium_2023,\n\ttitle = {Physcomitrium patens {PpRIC}, an ancestral {CRIB}-domain {ROP} effector, inhibits auxin-induced differentiation of apical initial cells},\n\tvolume = {42},\n\tissn = {2211-1247},\n\turl = {https://www.cell.com/cell-reports/abstract/S2211-1247(23)00141-9},\n\tdoi = {10.1016/j.celrep.2023.112130},\n\tabstract = {RHO guanosine triphosphatases are important eukaryotic regulators of cell differentiation and behavior. Plant ROP (RHO of plant) family members activate specific, incompletely characterized downstream signaling. The structurally simple land plant Physcomitrium patens is missing homologs of key animal and flowering plant RHO effectors but contains a single CRIB (CDC42/RAC interactive binding)-domain-containing RIC (ROP-interacting CRIB-containing) protein (PpRIC). Protonemal P. patens filaments elongate based on regular division and PpROP-dependent tip growth of apical initial cells, which upon stimulation by the hormone auxin differentiate caulonemal characteristics. PpRIC interacts with active PpROP1, co-localizes with this protein at the plasma membrane at the tip of apical initial cells, and accumulates in the nucleus. Remarkably, PpRIC is not required for tip growth but is targeted to the nucleus to block caulonema differentiation downstream of auxin-controlled gene expression. These observations establish functions of PpRIC in mediating crosstalk between ROP and auxin signaling, which contributes to the maintenance of apical initial cell identity.},\n\tlanguage = {English},\n\tnumber = {2},\n\turldate = {2023-02-23},\n\tjournal = {Cell Reports},\n\tauthor = {Ntefidou, Maria and Eklund, D. Magnus and Bail, Aude Le and Schulmeister, Sylwia and Scherbel, Franziska and Brandl, Lisa and Dörfler, Wolfgang and Eichstädt, Chantal and Bannmüller, Anna and Ljung, Karin and Kost, Benedikt},\n\tmonth = feb,\n\tyear = {2023},\n\tpmid = {36790931},\n\tnote = {Publisher: Elsevier},\n\tkeywords = {CP: Developmental biology, CP: Plants, CRIB domain, Physcomitrium patens, RHO/ROP GTPases, RHO/ROP effectors, auxin, cell differentiation, initial cells, land plant evolution, nuclear targeting, tip growth},\n}\n\n","author_short":["Ntefidou, M.","Eklund, D. M.","Bail, A. L.","Schulmeister, S.","Scherbel, F.","Brandl, L.","Dörfler, W.","Eichstädt, C.","Bannmüller, A.","Ljung, K.","Kost, B."],"key":"ntefidou_physcomitrium_2023","id":"ntefidou_physcomitrium_2023","bibbaseid":"ntefidou-eklund-bail-schulmeister-scherbel-brandl-drfler-eichstdt-etal-physcomitriumpatensppricanancestralcribdomainropeffectorinhibitsauxininduceddifferentiationofapicalinitialcells-2023","role":"author","urls":{"Paper":"https://www.cell.com/cell-reports/abstract/S2211-1247(23)00141-9"},"keyword":["CP: Developmental biology","CP: Plants","CRIB domain","Physcomitrium patens","RHO/ROP GTPases","RHO/ROP effectors","auxin","cell differentiation","initial cells","land plant evolution","nuclear targeting","tip growth"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["9cGcv2t8pRzC92kzs"],"keywords":["cp: developmental biology","cp: plants","crib domain","physcomitrium patens","rho/rop gtpases","rho/rop effectors","auxin","cell differentiation","initial cells","land plant evolution","nuclear targeting","tip growth"],"search_terms":["physcomitrium","patens","ppric","ancestral","crib","domain","rop","effector","inhibits","auxin","induced","differentiation","apical","initial","cells","ntefidou","eklund","bail","schulmeister","scherbel","brandl","dörfler","eichstädt","bannmüller","ljung","kost"],"title":"Physcomitrium patens PpRIC, an ancestral CRIB-domain ROP effector, inhibits auxin-induced differentiation of apical initial cells","year":2023}