Sperm motility-activating complex formed by t-complex distorters. Ogawa, K. and Inaba, K. Biochemical and Biophysical Research Communications, 310(4):1155–1159, October, 2003.
Sperm motility-activating complex formed by t-complex distorters [link]Paper  doi  abstract   bibtex   
Transmission ratio distortion is a dramatic example of non-Mendelian transmission. In mice, t-haplotype males produce dysfunctional +-sperm and normal t-sperm, leading to transmission in favor of t-sperm. Genetic studies have indicated that the t-complex responder locus, Tcr, rescues t-sperm but not +-sperm from defective products of t-complex distorter loci, Tcds. Light chain 1 (LC1) and LC3 from sea urchin sperm outer arm dynein have sequence similarities to Tctex2 and Tctex1, respectively, both of which are wild-type products of Tcds. We show here that LC1 and LC3 are able to make a 1:1 complex. Since Tcr is a member of the Smok (sperm motility kinase) family and LC1 is phosphorylated at the activation of sperm motility in a cAMP-dependent manner, this complex in a dynein motor molecule might be a direct target of Smok/Tcr kinase in a signal cascade that regulates sperm motility. Thus, we designate it as Smoac (sperm motility activating complex).
@article{ogawa_sperm_2003,
	title = {Sperm motility-activating complex formed by t-complex distorters},
	volume = {310},
	issn = {0006-291X},
	url = {http://www.sciencedirect.com/science/article/pii/S0006291X03019466},
	doi = {10.1016/j.bbrc.2003.09.137},
	abstract = {Transmission ratio distortion is a dramatic example of non-Mendelian transmission. In mice, t-haplotype males produce dysfunctional +-sperm and normal t-sperm, leading to transmission in favor of t-sperm. Genetic studies have indicated that the t-complex responder locus, Tcr, rescues t-sperm but not +-sperm from defective products of t-complex distorter loci, Tcds. Light chain 1 (LC1) and LC3 from sea urchin sperm outer arm dynein have sequence similarities to Tctex2 and Tctex1, respectively, both of which are wild-type products of Tcds. We show here that LC1 and LC3 are able to make a 1:1 complex. Since Tcr is a member of the Smok (sperm motility kinase) family and LC1 is phosphorylated at the activation of sperm motility in a cAMP-dependent manner, this complex in a dynein motor molecule might be a direct target of Smok/Tcr kinase in a signal cascade that regulates sperm motility. Thus, we designate it as Smoac (sperm motility activating complex).},
	language = {en},
	number = {4},
	urldate = {2020-03-03},
	journal = {Biochemical and Biophysical Research Communications},
	author = {Ogawa, Kazuo and Inaba, Kazuo},
	month = oct,
	year = {2003},
	keywords = {Inaba K},
	pages = {1155--1159}
}
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