Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging. Ogawa, S, Tank, D., Menon, R, Ellermann, J., Kim, S., Merkle, H, & Ugurbil, K PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF, 89(13):5951--5955, July, 1992. Paper abstract bibtex We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.
@article{ogawa_intrinsic_1992,
title = {Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging},
volume = {89},
issn = {0027-8424},
url = {http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=U1OokhpidJ9AEC9@2Ol&page=2&doc=12},
abstract = {We report that visual stimulation produces an easily detectable (5-20\%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.},
number = {13},
urldate = {2009-01-13},
journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF},
author = {Ogawa, S and Tank, DW and Menon, R and Ellermann, JM and Kim, SG and Merkle, H and Ugurbil, K},
month = jul,
year = {1992},
keywords = {BOLD, haemodynamics},
pages = {5951--5955},
file = {ISI Web of Knowledge Snapshot:/Users/nickb/Zotero/storage/WIFSPXN9/full_record.html:text/html;ogawa1992.pdf:/Users/nickb/Zotero/storage/NGBAMITH/ogawa1992.pdf:application/pdf}
}
Downloads: 0
{"_id":"ppTbSuEcvFdY6yKyv","bibbaseid":"ogawa-tank-menon-ellermann-kim-merkle-ugurbil-intrinsicsignalchangesaccompanyingsensorystimulationfunctionalbrainmappingwithmagneticresonanceimaging-1992","downloads":0,"creationDate":"2017-07-20T09:27:29.621Z","title":"Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging","author_short":["Ogawa, S","Tank, D.","Menon, R","Ellermann, J.","Kim, S.","Merkle, H","Ugurbil, K"],"year":1992,"bibtype":"article","biburl":"https://users.fmrib.ox.ac.uk/~nickb/ExportedItemsLge.bib","bibdata":{"bibtype":"article","type":"article","title":"Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging","volume":"89","issn":"0027-8424","url":"http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=U1OokhpidJ9AEC9@2Ol&page=2&doc=12","abstract":"We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.","number":"13","urldate":"2009-01-13","journal":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF","author":[{"propositions":[],"lastnames":["Ogawa"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Tank"],"firstnames":["DW"],"suffixes":[]},{"propositions":[],"lastnames":["Menon"],"firstnames":["R"],"suffixes":[]},{"propositions":[],"lastnames":["Ellermann"],"firstnames":["JM"],"suffixes":[]},{"propositions":[],"lastnames":["Kim"],"firstnames":["SG"],"suffixes":[]},{"propositions":[],"lastnames":["Merkle"],"firstnames":["H"],"suffixes":[]},{"propositions":[],"lastnames":["Ugurbil"],"firstnames":["K"],"suffixes":[]}],"month":"July","year":"1992","keywords":"BOLD, haemodynamics","pages":"5951--5955","file":"ISI Web of Knowledge Snapshot:/Users/nickb/Zotero/storage/WIFSPXN9/full_record.html:text/html;ogawa1992.pdf:/Users/nickb/Zotero/storage/NGBAMITH/ogawa1992.pdf:application/pdf","bibtex":"@article{ogawa_intrinsic_1992,\n\ttitle = {Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging},\n\tvolume = {89},\n\tissn = {0027-8424},\n\turl = {http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=U1OokhpidJ9AEC9@2Ol&page=2&doc=12},\n\tabstract = {We report that visual stimulation produces an easily detectable (5-20\\%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.},\n\tnumber = {13},\n\turldate = {2009-01-13},\n\tjournal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF},\n\tauthor = {Ogawa, S and Tank, DW and Menon, R and Ellermann, JM and Kim, SG and Merkle, H and Ugurbil, K},\n\tmonth = jul,\n\tyear = {1992},\n\tkeywords = {BOLD, haemodynamics},\n\tpages = {5951--5955},\n\tfile = {ISI Web of Knowledge Snapshot:/Users/nickb/Zotero/storage/WIFSPXN9/full_record.html:text/html;ogawa1992.pdf:/Users/nickb/Zotero/storage/NGBAMITH/ogawa1992.pdf:application/pdf}\n}\n\n","author_short":["Ogawa, S","Tank, D.","Menon, R","Ellermann, J.","Kim, S.","Merkle, H","Ugurbil, K"],"key":"ogawa_intrinsic_1992","id":"ogawa_intrinsic_1992","bibbaseid":"ogawa-tank-menon-ellermann-kim-merkle-ugurbil-intrinsicsignalchangesaccompanyingsensorystimulationfunctionalbrainmappingwithmagneticresonanceimaging-1992","role":"author","urls":{"Paper":"http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=U1OokhpidJ9AEC9@2Ol&page=2&doc=12"},"keyword":["BOLD","haemodynamics"],"downloads":0,"html":""},"search_terms":["intrinsic","signal","changes","accompanying","sensory","stimulation","functional","brain","mapping","magnetic","resonance","imaging","ogawa","tank","menon","ellermann","kim","merkle","ugurbil"],"keywords":["bold","haemodynamics"],"authorIDs":[],"dataSources":["ZnSCiZ543imjXQzRu"]}