Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging. Ogawa, S, Tank, D., Menon, R, Ellermann, J., Kim, S., Merkle, H, & Ugurbil, K PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF, 89(13):5951--5955, July, 1992. ![Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.
@article{ogawa_intrinsic_1992,
title = {Intrinsic signal changes accompanying sensory stimulation - functional brain mapping with magnetic-resonance-imaging},
volume = {89},
issn = {0027-8424},
url = {http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=U1OokhpidJ9AEC9@2Ol&page=2&doc=12},
abstract = {We report that visual stimulation produces an easily detectable (5-20\%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2*. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.},
number = {13},
urldate = {2009-01-13},
journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF},
author = {Ogawa, S and Tank, DW and Menon, R and Ellermann, JM and Kim, SG and Merkle, H and Ugurbil, K},
month = jul,
year = {1992},
keywords = {BOLD, haemodynamics},
pages = {5951--5955},
file = {ISI Web of Knowledge Snapshot:/Users/nickb/Zotero/storage/WIFSPXN9/full_record.html:text/html;ogawa1992.pdf:/Users/nickb/Zotero/storage/NGBAMITH/ogawa1992.pdf:application/pdf}
}
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