@article{
 title = {SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {C. elegans,Cholesterol,Dauer larva,Protein tyrosine phosphatase},
 volume = {130},
 id = {501c7b89-3769-3f2a-8054-88ec0c8db641},
 created = {2018-04-07T09:32:29.656Z},
 file_attached = {false},
 profile_id = {ee66f13e-7efe-3fbc-9397-2c957dcfaf2a},
 last_modified = {2018-04-07T09:32:29.656Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {The dauer larva of the nematode Caenorhabditis elegans is a good model system for investigating the regulation of developmental fates by environmental cues. Here we show that SDF-9, a protein tyrosine phosphatase-like molecule, is involved in the regulation of dauer larva formation. The dauer larva of sdf-9 mutants is different from a normal dauer larva but resembles the dauer-like larva of daf-9 and daf-12 dauer-constitutive mutants. Like these mutants, the dauer-constitutive phenotypes of sdf-9 mutants were greatly enhanced by cholesterol deprivation. Epistasis analyses, together with the relationship between sdf-9 mutations and daf-9 expression, suggested that SDF-9 increases the activity of DAF-9 or helps the execution of the DAF-9 function. SDF-9 was expressed in two head cells in which DAF-9 is expressed. By their position and by genetic mosaic experiments, we identified these cells as XXXL/R cells, which are known as embryonic hypodermal cells and whose function at later stages is unknown. Killing of the sdf-9-expressing cells in the wild-type first-stage larva induced formation of the dauer-like larva. Since this study on SDF-9 and former studies on DAF-9 showed that the functions of these proteins are related to those of steroids, XXXL/R cells seem to play a key role in the metabolism or function of a steroid hormone(s) that acts in dauer regulation.},
 bibtype = {article},
 author = {Ohkura, K. and Suzuki, N. and Ishihara, T. and Katsura, I.},
 journal = {Development},
 number = {14}
}

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