Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis. Oliveira-de-Souza, D., Vinhaes, C. L, Arriaga, M. B, Kumar, N. P., Queiroz, A. T L, Fukutani, K. F, Babu, S., & Andrade, B. B Scientific Reports, 10(1):11358, Nature Publishing Group, dec, 2020.
Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis [link]Paper  doi  abstract   bibtex   
Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specific biomarker profiles related to inflammation and the diverse clinical disease presentations in TB has been extensively studied in adults. However, relatively scarce data on profiling the inflammatory responses in pediatric TB are available. Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adults or children presenting with pulmonary or extrapulmonary disease. We used multidimensional statistical analyses to characterize the impact of age on the overall changes in the systemic inflammation profiles in subpopulation of TB patients. Our findings indicate that TB results in significant increases in molecular perturbation, with the highest values being detected in adult patients. Furthermore, there were unique differences in the biomarker perturbation patterns and the overall degree of inflammation according to disease site and age. Importantly, the molecular degree of perturbation was not influenced by sex. Our results revealed that aging is an important determinant of the differences in quality and magnitude of systemic inflammatory perturbation in distinct clinical forms of TB. Tuberculosis (TB) remains the leading cause of mortality worldwide due to a single agent 1. Mycobacterium tuberculosis (Mtb) is widely disseminated geographically and infects individuals of all ages, causing a wide spectrum of clinical manifestations associated with the host immunological status 2. The majority of the studies exploring immunopathogenesis in TB is restricted to the adult population. On the other hand, TB pathophysiology remains poorly understood in children, especially in those under 5 years-old 3-5. An important challenge in pediatric TB is the increased frequency of extrapulmonary presentations 6 , which can be paucibacillary and thus associated with challenges in microbiologic test confirmation, resulting in delayed therapy implementation. Inflammatory biomarkers in TB have been extensively studied and have gained prominence due to the potential use as host-based blood tests 7. Understanding the complexity of the inflammatory milieu during TB infection open
@article{Oliveira-de-Souza2020a,
abstract = {Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specific biomarker profiles related to inflammation and the diverse clinical disease presentations in TB has been extensively studied in adults. However, relatively scarce data on profiling the inflammatory responses in pediatric TB are available. Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adults or children presenting with pulmonary or extrapulmonary disease. We used multidimensional statistical analyses to characterize the impact of age on the overall changes in the systemic inflammation profiles in subpopulation of TB patients. Our findings indicate that TB results in significant increases in molecular perturbation, with the highest values being detected in adult patients. Furthermore, there were unique differences in the biomarker perturbation patterns and the overall degree of inflammation according to disease site and age. Importantly, the molecular degree of perturbation was not influenced by sex. Our results revealed that aging is an important determinant of the differences in quality and magnitude of systemic inflammatory perturbation in distinct clinical forms of TB. Tuberculosis (TB) remains the leading cause of mortality worldwide due to a single agent 1. Mycobacterium tuberculosis (Mtb) is widely disseminated geographically and infects individuals of all ages, causing a wide spectrum of clinical manifestations associated with the host immunological status 2. The majority of the studies exploring immunopathogenesis in TB is restricted to the adult population. On the other hand, TB pathophysiology remains poorly understood in children, especially in those under 5 years-old 3-5. An important challenge in pediatric TB is the increased frequency of extrapulmonary presentations 6 , which can be paucibacillary and thus associated with challenges in microbiologic test confirmation, resulting in delayed therapy implementation. Inflammatory biomarkers in TB have been extensively studied and have gained prominence due to the potential use as host-based blood tests 7. Understanding the complexity of the inflammatory milieu during TB infection open},
author = {Oliveira-de-Souza, Deivide and Vinhaes, Caian L and Arriaga, Mar{\'{i}}a B and Kumar, Nathella Pavan and Queiroz, Artur T L and Fukutani, Kiyoshi F and Babu, Subash and Andrade, Bruno B},
doi = {10.1038/s41598-020-68255-0},
file = {:C$\backslash$:/Users/Claire/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Oliveira-de-Souza et al. - 2020 - Aging increases the systemic molecular degree of inflammatory perturbation in patients with tubercu(2).pdf:pdf},
issn = {2045-2322},
journal = {Scientific Reports},
keywords = {Cytokines,Immunology,Infection,Infectious diseases,Inflammation,OA,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,fund{\_}not{\_}ack,original},
month = {dec},
number = {1},
pages = {11358},
publisher = {Nature Publishing Group},
title = {{Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis}},
url = {http://www.nature.com/articles/s41598-020-68255-0},
volume = {10},
year = {2020}
}
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