Isolation and characterization of new phenolic siderophores with antimicrobial properties from <i>Pseudomonas</i> sp. UIAU-6B. Oluwabusola, E. T, Adebisi, O. O, Reyes, F., Acquah, K. S, Cruz, M. D. L., Mweetwa, L. L, Rajakulendran, J. E, Warner, D. F, Hai, D., Ebel, R., & Jaspars, M. Beilstein Journal of Organic Chemistry, 17:2390–2398, Beilstein-Institut, sep, 2021.
Paper doi abstract bibtex Five new phenolic siderophores 1–5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseudomonas sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A–C (1–3) and pseudomobactin A and B (4 and 5) isolated alongside two known compounds, pseudomonine (6) and salicylic acid (7), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds 1–5 was determined by Marfey analysis. The antimicrobial evaluation of compound 4 exhibited the most potent activity against vancomycin-sensitive Enterococcus faecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to 32 µg/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds 1–5 were proposed.
@article{Oluwabusola2021,
abstract = {Five new phenolic siderophores 1–5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseudomonas sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A–C (1–3) and pseudomobactin A and B (4 and 5) isolated alongside two known compounds, pseudomonine (6) and salicylic acid (7), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds 1–5 was determined by Marfey analysis. The antimicrobial evaluation of compound 4 exhibited the most potent activity against vancomycin-sensitive Enterococcus faecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to 32 µg/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds 1–5 were proposed.},
author = {Oluwabusola, Emmanuel T and Adebisi, Olusoji O and Reyes, Fernando and Acquah, Kojo S and Cruz, Mercedes De La and Mweetwa, Larry L and Rajakulendran, Joy E and Warner, Digby F and Hai, Deng and Ebel, Rainer and Jaspars, Marcel},
doi = {10.3762/BJOC.17.156},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Oluwabusola et al. - 2021 - Isolation and characterization of new phenolic siderophores with antimicrobial properties from iPseudomonasi.pdf:pdf},
issn = {1860-5397},
journal = {Beilstein Journal of Organic Chemistry},
keywords = {Mycobacterium tuberculosis,OA,Phenolic siderophores,Pseudomonas sp.,fund{\_}not{\_}ack,original,pseudomonine,sensitive Enterococcus faecium,vancomycin},
mendeley-tags = {OA,fund{\_}not{\_}ack,original},
month = {sep},
pages = {2390--2398},
pmid = {34621401},
publisher = {Beilstein-Institut},
title = {{Isolation and characterization of new phenolic siderophores with antimicrobial properties from \textit{Pseudomonas} sp. UIAU-6B}},
url = {https://www.beilstein-journals.org/bjoc/articles/17/156},
volume = {17},
year = {2021}
}
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