Amygdala role in conditioned associative learning. Ono, T, Nishijo, H, & Uwano, T Prog Neurobiol, 46(4):401-22, 1995. abstract bibtex Amygdala role in emotion was reviewed in reference to recent amygdala lesion studies and neuronal responses in the rat amygdala to conditioned stimuli. Extensive lesion studies suggest that the amygdala is crucial in various kinds of motivated and emotional behavior, and related autonomic responses. These amygdala functions critically depend on learning and memory. Amygdala lesions, both before and after training of conditioned associative learning, impaired emotional expression without simple sensory-motor deficits. Pharmacological experiments indicated neurotransmission in the amygdala is mediated through NMDA and AMPA receptors. These results strongly suggest the amygdala involvement in acquiring and storing associative memory (i.e. stimulus-affect association), by which animals recognize and evaluate the biological significance of a stimulus. This information is then transferred to the brainstem executing system. In the neurophysiological experiments, there were topographic distributions of sensory-responsive neurons within the amygdala, which were well correlated to anatomical data. The responses of rat amygdala neurons changed plastically during learning. Furthermore, more sensory-responsive neurons were encountered in the amygdala of rats trained to associate the sensory stimuli with a reinforcement than in the amygdala of rats that were not trained. In trained rats, multimodal neurons that responded to conditioned and unconditioned stimuli were frequently found in the basolateral and central nuclei of the amygdala. The results suggest that basolateral and central nuclei are foci where various sensory modalities converge, and which might perform critical functions in acquiring and storing long-term associative memory to link between sensory information and affective significance.
@Article{Ono1995,
author = {T Ono and H Nishijo and T Uwano},
journal = {Prog Neurobiol},
title = {Amygdala role in conditioned associative learning.},
year = {1995},
number = {4},
pages = {401-22},
volume = {46},
abstract = {Amygdala role in emotion was reviewed in reference to recent amygdala
lesion studies and neuronal responses in the rat amygdala to conditioned
stimuli. Extensive lesion studies suggest that the amygdala is crucial
in various kinds of motivated and emotional behavior, and related
autonomic responses. These amygdala functions critically depend on
learning and memory. Amygdala lesions, both before and after training
of conditioned associative learning, impaired emotional expression
without simple sensory-motor deficits. Pharmacological experiments
indicated neurotransmission in the amygdala is mediated through NMDA
and AMPA receptors. These results strongly suggest the amygdala involvement
in acquiring and storing associative memory (i.e. stimulus-affect
association), by which animals recognize and evaluate the biological
significance of a stimulus. This information is then transferred
to the brainstem executing system. In the neurophysiological experiments,
there were topographic distributions of sensory-responsive neurons
within the amygdala, which were well correlated to anatomical data.
The responses of rat amygdala neurons changed plastically during
learning. Furthermore, more sensory-responsive neurons were encountered
in the amygdala of rats trained to associate the sensory stimuli
with a reinforcement than in the amygdala of rats that were not trained.
In trained rats, multimodal neurons that responded to conditioned
and unconditioned stimuli were frequently found in the basolateral
and central nuclei of the amygdala. The results suggest that basolateral
and central nuclei are foci where various sensory modalities converge,
and which might perform critical functions in acquiring and storing
long-term associative memory to link between sensory information
and affective significance.},
keywords = {Amygdala, Animals, Conditioning, Operant, Emotions, Hypothalamus, Learning, Support, Non-U.S. Gov't, 8532847},
}
Downloads: 0
{"_id":"4cq4TD6pdcJcwyAgP","bibbaseid":"ono-nishijo-uwano-amygdalaroleinconditionedassociativelearning-1995","author_short":["Ono, T","Nishijo, H","Uwano, T"],"bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["T"],"propositions":[],"lastnames":["Ono"],"suffixes":[]},{"firstnames":["H"],"propositions":[],"lastnames":["Nishijo"],"suffixes":[]},{"firstnames":["T"],"propositions":[],"lastnames":["Uwano"],"suffixes":[]}],"journal":"Prog Neurobiol","title":"Amygdala role in conditioned associative learning.","year":"1995","number":"4","pages":"401-22","volume":"46","abstract":"Amygdala role in emotion was reviewed in reference to recent amygdala lesion studies and neuronal responses in the rat amygdala to conditioned stimuli. Extensive lesion studies suggest that the amygdala is crucial in various kinds of motivated and emotional behavior, and related autonomic responses. These amygdala functions critically depend on learning and memory. Amygdala lesions, both before and after training of conditioned associative learning, impaired emotional expression without simple sensory-motor deficits. Pharmacological experiments indicated neurotransmission in the amygdala is mediated through NMDA and AMPA receptors. These results strongly suggest the amygdala involvement in acquiring and storing associative memory (i.e. stimulus-affect association), by which animals recognize and evaluate the biological significance of a stimulus. This information is then transferred to the brainstem executing system. In the neurophysiological experiments, there were topographic distributions of sensory-responsive neurons within the amygdala, which were well correlated to anatomical data. The responses of rat amygdala neurons changed plastically during learning. Furthermore, more sensory-responsive neurons were encountered in the amygdala of rats trained to associate the sensory stimuli with a reinforcement than in the amygdala of rats that were not trained. In trained rats, multimodal neurons that responded to conditioned and unconditioned stimuli were frequently found in the basolateral and central nuclei of the amygdala. The results suggest that basolateral and central nuclei are foci where various sensory modalities converge, and which might perform critical functions in acquiring and storing long-term associative memory to link between sensory information and affective significance.","keywords":"Amygdala, Animals, Conditioning, Operant, Emotions, Hypothalamus, Learning, Support, Non-U.S. Gov't, 8532847","bibtex":"@Article{Ono1995,\n author = {T Ono and H Nishijo and T Uwano},\n journal = {Prog Neurobiol},\n title = {Amygdala role in conditioned associative learning.},\n year = {1995},\n number = {4},\n pages = {401-22},\n volume = {46},\n abstract = {Amygdala role in emotion was reviewed in reference to recent amygdala\n\tlesion studies and neuronal responses in the rat amygdala to conditioned\n\tstimuli. Extensive lesion studies suggest that the amygdala is crucial\n\tin various kinds of motivated and emotional behavior, and related\n\tautonomic responses. These amygdala functions critically depend on\n\tlearning and memory. Amygdala lesions, both before and after training\n\tof conditioned associative learning, impaired emotional expression\n\twithout simple sensory-motor deficits. Pharmacological experiments\n\tindicated neurotransmission in the amygdala is mediated through NMDA\n\tand AMPA receptors. These results strongly suggest the amygdala involvement\n\tin acquiring and storing associative memory (i.e. stimulus-affect\n\tassociation), by which animals recognize and evaluate the biological\n\tsignificance of a stimulus. This information is then transferred\n\tto the brainstem executing system. In the neurophysiological experiments,\n\tthere were topographic distributions of sensory-responsive neurons\n\twithin the amygdala, which were well correlated to anatomical data.\n\tThe responses of rat amygdala neurons changed plastically during\n\tlearning. Furthermore, more sensory-responsive neurons were encountered\n\tin the amygdala of rats trained to associate the sensory stimuli\n\twith a reinforcement than in the amygdala of rats that were not trained.\n\tIn trained rats, multimodal neurons that responded to conditioned\n\tand unconditioned stimuli were frequently found in the basolateral\n\tand central nuclei of the amygdala. The results suggest that basolateral\n\tand central nuclei are foci where various sensory modalities converge,\n\tand which might perform critical functions in acquiring and storing\n\tlong-term associative memory to link between sensory information\n\tand affective significance.},\n keywords = {Amygdala, Animals, Conditioning, Operant, Emotions, Hypothalamus, Learning, Support, Non-U.S. Gov't, 8532847},\n}\n\n","author_short":["Ono, T","Nishijo, H","Uwano, T"],"key":"Ono1995","id":"Ono1995","bibbaseid":"ono-nishijo-uwano-amygdalaroleinconditionedassociativelearning-1995","role":"author","urls":{},"keyword":["Amygdala","Animals","Conditioning","Operant","Emotions","Hypothalamus","Learning","Support","Non-U.S. Gov't","8532847"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://endress.org/publications/ansgar.bib","dataSources":["xPGxHAeh3vZpx4yyE"],"keywords":["amygdala","animals","conditioning","operant","emotions","hypothalamus","learning","support","non-u.s. gov't","8532847"],"search_terms":["amygdala","role","conditioned","associative","learning","ono","nishijo","uwano"],"title":"Amygdala role in conditioned associative learning.","year":1995}