Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children. Orton, H., D., Szabo, N., J., Clare-Salzler, M., & Norris, J., M. Eur J Clin Nutr, 62(6):733-738, 2008.
Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children [link]Website  abstract   bibtex   
OBJECTIVE: We conducted a dietary validation study in youth aged 1-11 years by comparing dietary intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) as assessed by a parent-completed semiquantitative food frequency questionnaire (FFQ) over time to erythrocyte membrane composition of the same fatty acids. DESIGN: The study population included youth aged 1-11 years who were participants in the Diabetes Autoimmunity Study in the Young (DAISY), a longitudinal study in Denver, Colorado that is following a cohort of youth at risk for developing type I diabetes. Four hundred and four children who had erythrocyte membrane fatty acid data matched to an FFQ corresponding to the same time frame for a total of 917 visits (matches) were included. PUFA intake was expressed both as g/day (adjusted for total energy) and as percent of total fat intake. We used mixed models to test the association and calculate the correlation between the erythrocyte membrane estimates and PUFA intake using all records of data for each youth. RESULTS: Intakes of total omega-3 fatty acids (beta=0.52, P<0.0001, rho=0.23) and marine PUFAs (beta=1.62, P<0.0001, rho=0.42), as a percent of total fat in the diet, were associated with percent of omega-3 and marine PUFAs in the erythrocyte membrane. Intakes of omega-6 PUFAs (beta=0.04, P=0.418, rho=0.05) and arachidonic acid (beta=0.31, P=0.774, rho=0.01) were not associated. CONCLUSIONS: In these young children, an FFQ using parental report provided estimates of average long-term intakes of marine PUFAs that correlated well with their erythrocyte cell membrane fatty acid status.
@article{
 title = {Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {*Diet,Biological Markers/blood,Child,Child, Preschool,Cohort Studies,Colorado,Cross-Sectional Studies,Diet Surveys,Dietary Fats, Unsaturated/*administration & dosage,Erythrocyte Membrane/*chemistry,Fatty Acids, Omega-3/*administration & dosage/anal,Fatty Acids, Omega-6/*administration & dosage/*ana,Female,Humans,Infant,Longitudinal Studies,Male,Questionnaires/*standards,Reproducibility of Results,Seafood,Sensitivity and Specificity},
 pages = {733-738},
 volume = {62},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17440518},
 edition = {2007/04/19},
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 notes = {<m:note>Orton, H D<m:linebreak/>Szabo, N J<m:linebreak/>Clare-Salzler, M<m:linebreak/>Norris, J M<m:linebreak/>DK32493/DK/NIDDK NIH HHS/United States<m:linebreak/>P30 DK 57516/DK/NIDDK NIH HHS/United States<m:linebreak/>P30 DK057516-019004/DK/NIDDK NIH HHS/United States<m:linebreak/>R01 DK049654-06/DK/NIDDK NIH HHS/United States<m:linebreak/>R01-DK49654/DK/NIDDK NIH HHS/United States<m:linebreak/>R37 DK032493-18/DK/NIDDK NIH HHS/United States<m:linebreak/>Research Support, N.I.H., Extramural<m:linebreak/>Validation Studies<m:linebreak/>England<m:linebreak/>European journal of clinical nutrition<m:linebreak/>1602763<m:linebreak/>Eur J Clin Nutr. 2008 Jun;62(6):733-8. Epub 2007 Apr 18.</m:note>},
 abstract = {OBJECTIVE: We conducted a dietary validation study in youth aged 1-11 years by comparing dietary intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) as assessed by a parent-completed semiquantitative food frequency questionnaire (FFQ) over time to erythrocyte membrane composition of the same fatty acids. DESIGN: The study population included youth aged 1-11 years who were participants in the Diabetes Autoimmunity Study in the Young (DAISY), a longitudinal study in Denver, Colorado that is following a cohort of youth at risk for developing type I diabetes. Four hundred and four children who had erythrocyte membrane fatty acid data matched to an FFQ corresponding to the same time frame for a total of 917 visits (matches) were included. PUFA intake was expressed both as g/day (adjusted for total energy) and as percent of total fat intake. We used mixed models to test the association and calculate the correlation between the erythrocyte membrane estimates and PUFA intake using all records of data for each youth. RESULTS: Intakes of total omega-3 fatty acids (beta=0.52, P<0.0001, rho=0.23) and marine PUFAs (beta=1.62, P<0.0001, rho=0.42), as a percent of total fat in the diet, were associated with percent of omega-3 and marine PUFAs in the erythrocyte membrane. Intakes of omega-6 PUFAs (beta=0.04, P=0.418, rho=0.05) and arachidonic acid (beta=0.31, P=0.774, rho=0.01) were not associated. CONCLUSIONS: In these young children, an FFQ using parental report provided estimates of average long-term intakes of marine PUFAs that correlated well with their erythrocyte cell membrane fatty acid status.},
 bibtype = {article},
 author = {Orton, H D and Szabo, N J and Clare-Salzler, M and Norris, J M},
 journal = {Eur J Clin Nutr},
 number = {6}
}

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