Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test. Ortonne, J., P. & Queille-Roussel, C. J Eur Acad Dermatol Venereol, 21 Suppl 2:19-25, 2007. ![Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex BACKGROUND: Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin. AIM: To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin. DESIGN AND METHODS: Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6. RESULTS: On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated. CONCLUSIONS: Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.
@article{
title = {Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test},
type = {article},
year = {2007},
identifiers = {[object Object]},
keywords = {Administration, Topical,Adult,Dermatitis/*drug therapy/etiology,Emulsions/administration & dosage/*therapeutic use,Female,Humans,Ointments/administration & dosage/*therapeutic use,Skin Diseases/*drug therapy,Time Factors},
pages = {19-25},
volume = {21 Suppl 2},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17716288},
edition = {2007/10/11},
id = {c89a6be1-0a00-3dab-907a-652b3b2e3703},
created = {2017-06-19T13:45:20.603Z},
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language = {eng},
notes = {<m:note>Ortonne, J-P<m:linebreak/>Queille-Roussel, C<m:linebreak/>Randomized Controlled Trial<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>Netherlands<m:linebreak/>Journal of the European Academy of Dermatology and Venereology : JEADV<m:linebreak/>Jdv2383<m:linebreak/>J Eur Acad Dermatol Venereol. 2007 Sep;21 Suppl 2:19-25.</m:note>},
abstract = {BACKGROUND: Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin. AIM: To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin. DESIGN AND METHODS: Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6. RESULTS: On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated. CONCLUSIONS: Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.},
bibtype = {article},
author = {Ortonne, J P and Queille-Roussel, C},
journal = {J Eur Acad Dermatol Venereol}
}
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