@ARTICLE{Ostrem2014-ds,
  title    = "Control of outer radial glial stem cell mitosis in the human
              brain",
  author   = "Ostrem, Bridget E L and Lui, Jan H and Gertz, Caitlyn C and
              Kriegstein, Arnold R",
  abstract = "Evolutionary expansion of the human neocortex is partially
              attributed to a relative abundance of neural stem cells in the
              fetal brain called outer radial glia (oRG). oRG cells display a
              characteristic division mode, mitotic somal translocation (MST),
              in which the soma rapidly translocates toward the cortical plate
              immediately prior to cytokinesis. MST may be essential for
              progenitor zone expansion, but the mechanism of MST is unknown,
              hindering exploration of its function in development and disease.
              Here, we show that MST requires activation of the Rho effector
              ROCK and nonmuscle myosin II, but not intact microtubules,
              centrosomal translocation into the leading process, or calcium
              influx. MST is independent of mitosis and distinct from
              interkinetic nuclear migration and saltatory migration. Our
              findings suggest that disrupted MST may underlie
              neurodevelopmental diseases affecting the Rho-ROCK-myosin pathway
              and provide a foundation for future exploration of the role of
              MST in neocortical development, evolution, and disease.",
  journal  = "Cell Rep",
  volume   =  8,
  number   =  3,
  pages    = "656--664",
  month    =  jul,
  year     =  2014,
  language = "en"
}

{"_id":"5afdymLA6rZB7N5mZ","bibbaseid":"ostrem-lui-gertz-kriegstein-controlofouterradialglialstemcellmitosisinthehumanbrain-2014","author_short":["Ostrem, B. E L","Lui, J. H","Gertz, C. C","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Control of outer radial glial stem cell mitosis in the human brain","author":[{"propositions":[],"lastnames":["Ostrem"],"firstnames":["Bridget","E","L"],"suffixes":[]},{"propositions":[],"lastnames":["Lui"],"firstnames":["Jan","H"],"suffixes":[]},{"propositions":[],"lastnames":["Gertz"],"firstnames":["Caitlyn","C"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (oRG). oRG cells display a characteristic division mode, mitotic somal translocation (MST), in which the soma rapidly translocates toward the cortical plate immediately prior to cytokinesis. MST may be essential for progenitor zone expansion, but the mechanism of MST is unknown, hindering exploration of its function in development and disease. Here, we show that MST requires activation of the Rho effector ROCK and nonmuscle myosin II, but not intact microtubules, centrosomal translocation into the leading process, or calcium influx. MST is independent of mitosis and distinct from interkinetic nuclear migration and saltatory migration. Our findings suggest that disrupted MST may underlie neurodevelopmental diseases affecting the Rho-ROCK-myosin pathway and provide a foundation for future exploration of the role of MST in neocortical development, evolution, and disease.","journal":"Cell Rep","volume":"8","number":"3","pages":"656–664","month":"July","year":"2014","language":"en","bibtex":"@ARTICLE{Ostrem2014-ds,\n title = \"Control of outer radial glial stem cell mitosis in the human\n brain\",\n author = \"Ostrem, Bridget E L and Lui, Jan H and Gertz, Caitlyn C and\n Kriegstein, Arnold R\",\n abstract = \"Evolutionary expansion of the human neocortex is partially\n attributed to a relative abundance of neural stem cells in the\n fetal brain called outer radial glia (oRG). oRG cells display a\n characteristic division mode, mitotic somal translocation (MST),\n in which the soma rapidly translocates toward the cortical plate\n immediately prior to cytokinesis. MST may be essential for\n progenitor zone expansion, but the mechanism of MST is unknown,\n hindering exploration of its function in development and disease.\n Here, we show that MST requires activation of the Rho effector\n ROCK and nonmuscle myosin II, but not intact microtubules,\n centrosomal translocation into the leading process, or calcium\n influx. MST is independent of mitosis and distinct from\n interkinetic nuclear migration and saltatory migration. Our\n findings suggest that disrupted MST may underlie\n neurodevelopmental diseases affecting the Rho-ROCK-myosin pathway\n and provide a foundation for future exploration of the role of\n MST in neocortical development, evolution, and disease.\",\n journal = \"Cell Rep\",\n volume = 8,\n number = 3,\n pages = \"656--664\",\n month = jul,\n year = 2014,\n language = \"en\"\n}\n\n","author_short":["Ostrem, B. E L","Lui, J. H","Gertz, C. C","Kriegstein, A. R"],"key":"Ostrem2014-ds","id":"Ostrem2014-ds","bibbaseid":"ostrem-lui-gertz-kriegstein-controlofouterradialglialstemcellmitosisinthehumanbrain-2014","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["control","outer","radial","glial","stem","cell","mitosis","human","brain","ostrem","lui","gertz","kriegstein"],"title":"Control of outer radial glial stem cell mitosis in the human brain","year":2014}