@article{owen_comparing_2020,
	title = {Comparing associations between frailty and mortality in hospitalised older adults with or without {COVID}-19 infection: a retrospective observational study using electronic health records},
	issn = {1468-2834},
	shorttitle = {Comparing associations between frailty and mortality in hospitalised older adults with or without {COVID}-19 infection},
	doi = {10.1093/ageing/afaa167},
	abstract = {BACKGROUND: The aim of this study was to describe outcomes in hospitalised older people with different levels of frailty and COVID-19 infection.
METHODS: We undertook a single centre, retrospective cohort study examining COVID-19 related mortality using Electronic Health Records, for older people (65 and over) with frailty, hospitalised with or without COVID-19 infection. Baseline covariates included demographics, Early Warning Scores, Charlson Comorbidity Indices and frailty (Clinical Frailty Scale, CFS), linked to COVID-19 status.
FINDINGS: We analysed outcomes on 1,071 patients with COVID-19 test results; 285 (27\%) were positive for COVID-19.)The mean age at ED arrival was 79.7 and 49.4\% were female. All-cause mortality (by 30 days) rose from 9\% (not frail) through to 33\% (severely frail) in the COVID negative cohort but was around 60\% for all frailty categories in the COVID positive cohort. In adjusted analyses, the hazard ratio for death in those with COVID-19 compared to those without COVID-19 was 7.3, 95\% CI: 3.00, 18.0) with age, comorbidities and illness severity making small additional contributions.
INTERPRETATION: In this study frailty, measured using the Clinical Frailty Scale, appeared to make little incremental contribution to the hazard of dying in older people hospitalised with COVID-19 infection; illness severity and comorbidity had a modest association with the overall adjusted hazard of death, whereas confirmed COVID-19 infection dominated, with a seven-fold hazard for death.},
	language = {eng},
	journal = {Age and Ageing},
	author = {Owen, R.K. and Conroy, S.P. and Taub, N. and Jones, W. and Bryden, D. and Pareek, M. and Faull, C. and Abrams, K.R. and Davis, D. and Banerjee, J.},
	month = jul,
	year = {2020},
	keywords = {COVID-19, Cohort study, Frailty, older people},
}

{"_id":"xu5Xx8taWRvzLgoWD","bibbaseid":"owen-conroy-taub-jones-bryden-pareek-faull-abrams-etal-comparingassociationsbetweenfrailtyandmortalityinhospitalisedolderadultswithorwithoutcovid19infectionaretrospectiveobservationalstudyusingelectronichealthrecords-2020","authorIDs":[],"author_short":["Owen, R.","Conroy, S.","Taub, N.","Jones, W.","Bryden, D.","Pareek, M.","Faull, C.","Abrams, K.","Davis, D.","Banerjee, J."],"bibdata":{"bibtype":"article","type":"article","title":"Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using electronic health records","issn":"1468-2834","shorttitle":"Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection","doi":"10.1093/ageing/afaa167","abstract":"BACKGROUND: The aim of this study was to describe outcomes in hospitalised older people with different levels of frailty and COVID-19 infection. METHODS: We undertook a single centre, retrospective cohort study examining COVID-19 related mortality using Electronic Health Records, for older people (65 and over) with frailty, hospitalised with or without COVID-19 infection. Baseline covariates included demographics, Early Warning Scores, Charlson Comorbidity Indices and frailty (Clinical Frailty Scale, CFS), linked to COVID-19 status. FINDINGS: We analysed outcomes on 1,071 patients with COVID-19 test results; 285 (27%) were positive for COVID-19.)The mean age at ED arrival was 79.7 and 49.4% were female. All-cause mortality (by 30 days) rose from 9% (not frail) through to 33% (severely frail) in the COVID negative cohort but was around 60% for all frailty categories in the COVID positive cohort. In adjusted analyses, the hazard ratio for death in those with COVID-19 compared to those without COVID-19 was 7.3, 95% CI: 3.00, 18.0) with age, comorbidities and illness severity making small additional contributions. INTERPRETATION: In this study frailty, measured using the Clinical Frailty Scale, appeared to make little incremental contribution to the hazard of dying in older people hospitalised with COVID-19 infection; illness severity and comorbidity had a modest association with the overall adjusted hazard of death, whereas confirmed COVID-19 infection dominated, with a seven-fold hazard for death.","language":"eng","journal":"Age and Ageing","author":[{"propositions":[],"lastnames":["Owen"],"firstnames":["R.K."],"suffixes":[]},{"propositions":[],"lastnames":["Conroy"],"firstnames":["S.P."],"suffixes":[]},{"propositions":[],"lastnames":["Taub"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Jones"],"firstnames":["W."],"suffixes":[]},{"propositions":[],"lastnames":["Bryden"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Pareek"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Faull"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Abrams"],"firstnames":["K.R."],"suffixes":[]},{"propositions":[],"lastnames":["Davis"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Banerjee"],"firstnames":["J."],"suffixes":[]}],"month":"July","year":"2020","keywords":"COVID-19, Cohort study, Frailty, older people","bibtex":"@article{owen_comparing_2020,\n\ttitle = {Comparing associations between frailty and mortality in hospitalised older adults with or without {COVID}-19 infection: a retrospective observational study using electronic health records},\n\tissn = {1468-2834},\n\tshorttitle = {Comparing associations between frailty and mortality in hospitalised older adults with or without {COVID}-19 infection},\n\tdoi = {10.1093/ageing/afaa167},\n\tabstract = {BACKGROUND: The aim of this study was to describe outcomes in hospitalised older people with different levels of frailty and COVID-19 infection.\nMETHODS: We undertook a single centre, retrospective cohort study examining COVID-19 related mortality using Electronic Health Records, for older people (65 and over) with frailty, hospitalised with or without COVID-19 infection. Baseline covariates included demographics, Early Warning Scores, Charlson Comorbidity Indices and frailty (Clinical Frailty Scale, CFS), linked to COVID-19 status.\nFINDINGS: We analysed outcomes on 1,071 patients with COVID-19 test results; 285 (27\\%) were positive for COVID-19.)The mean age at ED arrival was 79.7 and 49.4\\% were female. All-cause mortality (by 30 days) rose from 9\\% (not frail) through to 33\\% (severely frail) in the COVID negative cohort but was around 60\\% for all frailty categories in the COVID positive cohort. In adjusted analyses, the hazard ratio for death in those with COVID-19 compared to those without COVID-19 was 7.3, 95\\% CI: 3.00, 18.0) with age, comorbidities and illness severity making small additional contributions.\nINTERPRETATION: In this study frailty, measured using the Clinical Frailty Scale, appeared to make little incremental contribution to the hazard of dying in older people hospitalised with COVID-19 infection; illness severity and comorbidity had a modest association with the overall adjusted hazard of death, whereas confirmed COVID-19 infection dominated, with a seven-fold hazard for death.},\n\tlanguage = {eng},\n\tjournal = {Age and Ageing},\n\tauthor = {Owen, R.K. and Conroy, S.P. and Taub, N. and Jones, W. and Bryden, D. and Pareek, M. and Faull, C. and Abrams, K.R. and Davis, D. and Banerjee, J.},\n\tmonth = jul,\n\tyear = {2020},\n\tkeywords = {COVID-19, Cohort study, Frailty, older people},\n}\n\n","author_short":["Owen, R.","Conroy, S.","Taub, N.","Jones, W.","Bryden, D.","Pareek, M.","Faull, C.","Abrams, K.","Davis, D.","Banerjee, J."],"key":"owen_comparing_2020","id":"owen_comparing_2020","bibbaseid":"owen-conroy-taub-jones-bryden-pareek-faull-abrams-etal-comparingassociationsbetweenfrailtyandmortalityinhospitalisedolderadultswithorwithoutcovid19infectionaretrospectiveobservationalstudyusingelectronichealthrecords-2020","role":"author","urls":{},"keyword":["COVID-19","Cohort study","Frailty","older people"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://api.zotero.org/groups/2370791/items?key=xZUdkZVhlhTAvt1X1CRQzNcj&format=bibtex&limit=100","creationDate":"2021-03-10T13:27:05.973Z","downloads":1,"keywords":["covid-19","cohort study","frailty","older people"],"search_terms":["comparing","associations","between","frailty","mortality","hospitalised","older","adults","without","covid","infection","retrospective","observational","study","using","electronic","health","records","owen","conroy","taub","jones","bryden","pareek","faull","abrams","davis","banerjee"],"title":"Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using electronic health records","year":2020,"dataSources":["D2Q39xf6WKbfdGeLv","LiQPGJg2JYtcSm8X3"]}