@article{Pagano2007,
	title = {Energetics of quadruplex-drug recognition in anticancer therapy.},
	volume = {7},
	issn = {1873-5576},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17896919},
	abstract = {Immortality of tumour cells is strictly correlated to telomerase activity. Telomerase is overexpressed in about 85\% of tumour cells and maintains telomere length contributing to cell immortalisation, whereas in somatic cells telomeres progressively shorten until cell death occurs by apoptosis. Different drugs can promote telomeric G-rich overhangs which fold into quadruplex structures that inhibit telomerase activity. Detailed studies on drug-quadruplex complexes are essential to understand quadruplex recognition and address drug design. This review will discuss the energetic aspects of quadruplex-drug interactions with a particular attention to physico-chemical methodologies.},
	number = {6},
	journal = {Current cancer drug targets},
	author = {Pagano, B and Giancola, C},
	month = oct,
	year = {2007},
	pmid = {17896919},
	keywords = {\#nosource, Antineoplastic Agents, Antineoplastic Agents: pharmacology, Humans, Telomerase, Telomerase: metabolism, Telomere},
	pages = {520--40},
}

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