Implementing a Decision-Theoretic Design in Clinical Trials: Why and How?. Palmer, C. R. & Shahumyan, H. Stat Med, 26:4939-4957, 2007.
bibtex   
@article{pal07imp,
  title = {Implementing a Decision-Theoretic Design in Clinical Trials: {{Why}} and How?},
  volume = {26},
  journal = {Stat Med},
  author = {Palmer, Christoper R. and Shahumyan, Harutyun},
  year = {2007},
  keywords = {rct,software,ethics,data-dependent-designs,decision-theoretic-approach,history},
  pages = {4939-4957},
  citeulike-article-id = {13265635},
  posted-at = {2014-07-14 14:10:00},
  priority = {0},
  annote = {Benefits of a decision-theoretic approach to clinical trials;excellent summary of ethical issues;first known clinical trial}
}

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