Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols. Papahatjis, D. P., Nikas, S. P., Andreou, T., & Makriyannis, A. Bioorganic \& Medicinal Chemistry Letters, 12(24):3583--3586, December, 2002. Paper doi abstract bibtex 1′,1′-Cyclopropyl side chain substituents enhance the affinities of Δ8-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1′,1′-cyclopropyl analogues are described.
@article{ papahatjis_novel_2002,
title = {Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols},
volume = {12},
issn = {0960-894X},
url = {http://www.sciencedirect.com/science/article/pii/S0960894X02007850},
doi = {10.1016/S0960-894X(02)00785-0},
abstract = {1′,1′-Cyclopropyl side chain substituents enhance the affinities of Δ8-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1′,1′-cyclopropyl analogues are described.},
number = {24},
urldate = {2015-02-25TZ},
journal = {Bioorganic \& Medicinal Chemistry Letters},
author = {Papahatjis, Demetris P. and Nikas, Spyros P. and Andreou, Thanos and Makriyannis, Alexandros},
month = {December},
year = {2002},
pages = {3583--3586}
}
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