Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols. Papahatjis, D. P., Nikas, S. P., Andreou, T., & Makriyannis, A. Bioorganic \& Medicinal Chemistry Letters, 12(24):3583--3586, December, 2002.
Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols [link]Paper  doi  abstract   bibtex   
1′,1′-Cyclopropyl side chain substituents enhance the affinities of Δ8-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1′,1′-cyclopropyl analogues are described.
@article{ papahatjis_novel_2002,
  title = {Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols},
  volume = {12},
  issn = {0960-894X},
  url = {http://www.sciencedirect.com/science/article/pii/S0960894X02007850},
  doi = {10.1016/S0960-894X(02)00785-0},
  abstract = {1′,1′-Cyclopropyl side chain substituents enhance the affinities of Δ8-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1′,1′-cyclopropyl analogues are described.},
  number = {24},
  urldate = {2015-02-25TZ},
  journal = {Bioorganic \& Medicinal Chemistry Letters},
  author = {Papahatjis, Demetris P. and Nikas, Spyros P. and Andreou, Thanos and Makriyannis, Alexandros},
  month = {December},
  year = {2002},
  pages = {3583--3586}
}

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