@ARTICLE{Paredes2022-ro,
  title    = "Nests of dividing neuroblasts sustain interneuron production for
              the developing human brain",
  author   = "Paredes, Mercedes F and Mora, Cristina and Flores-Ramirez,
              Quetzal and Cebrian-Silla, Arantxa and Del Dosso, Ashley and
              Larimer, Phil and Chen, Jiapei and Kang, Gugene and Gonzalez
              Granero, Susana and Garcia, Eric and Chu, Julia and Delgado, Ryan
              and Cotter, Jennifer A and Tang, Vivian and Spatazza, Julien and
              Obernier, Kirsten and Ferrer Lozano, Jaime and Vento, Maximo and
              Scott, Julia and Studholme, Colin and Nowakowski, Tomasz J and
              Kriegstein, Arnold R and Oldham, Michael C and Hasenstaub, Andrea
              and Garcia-Verdugo, Jose Manuel and Alvarez-Buylla, Arturo and
              Huang, Eric J",
  abstract = "The human cortex contains inhibitory interneurons derived from
              the medial ganglionic eminence (MGE), a germinal zone in the
              embryonic ventral forebrain. How this germinal zone generates
              sufficient interneurons for the human brain remains unclear. We
              found that the human MGE (hMGE) contains nests of proliferative
              neuroblasts with ultrastructural and transcriptomic features that
              distinguish them from other progenitors in the hMGE. When
              dissociated hMGE cells are transplanted into the neonatal mouse
              brain, they reform into nests containing proliferating
              neuroblasts that generate young neurons that migrate extensively
              into the mouse forebrain and mature into different subtypes of
              functional interneurons. Together, these results indicate that
              the nest organization and sustained proliferation of neuroblasts
              in the hMGE provide a mechanism for the extended production of
              interneurons for the human forebrain.",
  journal  = "Science",
  volume   =  375,
  number   =  6579,
  pages    = "eabk2346",
  month    =  jan,
  year     =  2022,
  language = "en"
}

{"_id":"FHgffFcQ22SvJ7nrX","bibbaseid":"paredes-mora-floresramirez-cebriansilla-deldosso-larimer-chen-kang-etal-nestsofdividingneuroblastssustaininterneuronproductionforthedevelopinghumanbrain-2022","author_short":["Paredes, M. F","Mora, C.","Flores-Ramirez, Q.","Cebrian-Silla, A.","Del Dosso, A.","Larimer, P.","Chen, J.","Kang, G.","Gonzalez Granero, S.","Garcia, E.","Chu, J.","Delgado, R.","Cotter, J. A","Tang, V.","Spatazza, J.","Obernier, K.","Ferrer Lozano, J.","Vento, M.","Scott, J.","Studholme, C.","Nowakowski, T. J","Kriegstein, A. R","Oldham, M. C","Hasenstaub, A.","Garcia-Verdugo, J. M.","Alvarez-Buylla, A.","Huang, E. J"],"bibdata":{"bibtype":"article","type":"article","title":"Nests of dividing neuroblasts sustain interneuron production for the developing human brain","author":[{"propositions":[],"lastnames":["Paredes"],"firstnames":["Mercedes","F"],"suffixes":[]},{"propositions":[],"lastnames":["Mora"],"firstnames":["Cristina"],"suffixes":[]},{"propositions":[],"lastnames":["Flores-Ramirez"],"firstnames":["Quetzal"],"suffixes":[]},{"propositions":[],"lastnames":["Cebrian-Silla"],"firstnames":["Arantxa"],"suffixes":[]},{"propositions":[],"lastnames":["Del","Dosso"],"firstnames":["Ashley"],"suffixes":[]},{"propositions":[],"lastnames":["Larimer"],"firstnames":["Phil"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Jiapei"],"suffixes":[]},{"propositions":[],"lastnames":["Kang"],"firstnames":["Gugene"],"suffixes":[]},{"propositions":[],"lastnames":["Gonzalez","Granero"],"firstnames":["Susana"],"suffixes":[]},{"propositions":[],"lastnames":["Garcia"],"firstnames":["Eric"],"suffixes":[]},{"propositions":[],"lastnames":["Chu"],"firstnames":["Julia"],"suffixes":[]},{"propositions":[],"lastnames":["Delgado"],"firstnames":["Ryan"],"suffixes":[]},{"propositions":[],"lastnames":["Cotter"],"firstnames":["Jennifer","A"],"suffixes":[]},{"propositions":[],"lastnames":["Tang"],"firstnames":["Vivian"],"suffixes":[]},{"propositions":[],"lastnames":["Spatazza"],"firstnames":["Julien"],"suffixes":[]},{"propositions":[],"lastnames":["Obernier"],"firstnames":["Kirsten"],"suffixes":[]},{"propositions":[],"lastnames":["Ferrer","Lozano"],"firstnames":["Jaime"],"suffixes":[]},{"propositions":[],"lastnames":["Vento"],"firstnames":["Maximo"],"suffixes":[]},{"propositions":[],"lastnames":["Scott"],"firstnames":["Julia"],"suffixes":[]},{"propositions":[],"lastnames":["Studholme"],"firstnames":["Colin"],"suffixes":[]},{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","J"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Oldham"],"firstnames":["Michael","C"],"suffixes":[]},{"propositions":[],"lastnames":["Hasenstaub"],"firstnames":["Andrea"],"suffixes":[]},{"propositions":[],"lastnames":["Garcia-Verdugo"],"firstnames":["Jose","Manuel"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarez-Buylla"],"firstnames":["Arturo"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Eric","J"],"suffixes":[]}],"abstract":"The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic ventral forebrain. How this germinal zone generates sufficient interneurons for the human brain remains unclear. We found that the human MGE (hMGE) contains nests of proliferative neuroblasts with ultrastructural and transcriptomic features that distinguish them from other progenitors in the hMGE. When dissociated hMGE cells are transplanted into the neonatal mouse brain, they reform into nests containing proliferating neuroblasts that generate young neurons that migrate extensively into the mouse forebrain and mature into different subtypes of functional interneurons. Together, these results indicate that the nest organization and sustained proliferation of neuroblasts in the hMGE provide a mechanism for the extended production of interneurons for the human forebrain.","journal":"Science","volume":"375","number":"6579","pages":"eabk2346","month":"January","year":"2022","language":"en","bibtex":"@ARTICLE{Paredes2022-ro,\n title = \"Nests of dividing neuroblasts sustain interneuron production for\n the developing human brain\",\n author = \"Paredes, Mercedes F and Mora, Cristina and Flores-Ramirez,\n Quetzal and Cebrian-Silla, Arantxa and Del Dosso, Ashley and\n Larimer, Phil and Chen, Jiapei and Kang, Gugene and Gonzalez\n Granero, Susana and Garcia, Eric and Chu, Julia and Delgado, Ryan\n and Cotter, Jennifer A and Tang, Vivian and Spatazza, Julien and\n Obernier, Kirsten and Ferrer Lozano, Jaime and Vento, Maximo and\n Scott, Julia and Studholme, Colin and Nowakowski, Tomasz J and\n Kriegstein, Arnold R and Oldham, Michael C and Hasenstaub, Andrea\n and Garcia-Verdugo, Jose Manuel and Alvarez-Buylla, Arturo and\n Huang, Eric J\",\n abstract = \"The human cortex contains inhibitory interneurons derived from\n the medial ganglionic eminence (MGE), a germinal zone in the\n embryonic ventral forebrain. How this germinal zone generates\n sufficient interneurons for the human brain remains unclear. We\n found that the human MGE (hMGE) contains nests of proliferative\n neuroblasts with ultrastructural and transcriptomic features that\n distinguish them from other progenitors in the hMGE. When\n dissociated hMGE cells are transplanted into the neonatal mouse\n brain, they reform into nests containing proliferating\n neuroblasts that generate young neurons that migrate extensively\n into the mouse forebrain and mature into different subtypes of\n functional interneurons. Together, these results indicate that\n the nest organization and sustained proliferation of neuroblasts\n in the hMGE provide a mechanism for the extended production of\n interneurons for the human forebrain.\",\n journal = \"Science\",\n volume = 375,\n number = 6579,\n pages = \"eabk2346\",\n month = jan,\n year = 2022,\n language = \"en\"\n}\n\n","author_short":["Paredes, M. F","Mora, C.","Flores-Ramirez, Q.","Cebrian-Silla, A.","Del Dosso, A.","Larimer, P.","Chen, J.","Kang, G.","Gonzalez Granero, S.","Garcia, E.","Chu, J.","Delgado, R.","Cotter, J. A","Tang, V.","Spatazza, J.","Obernier, K.","Ferrer Lozano, J.","Vento, M.","Scott, J.","Studholme, C.","Nowakowski, T. J","Kriegstein, A. R","Oldham, M. C","Hasenstaub, A.","Garcia-Verdugo, J. M.","Alvarez-Buylla, A.","Huang, E. J"],"key":"Paredes2022-ro","id":"Paredes2022-ro","bibbaseid":"paredes-mora-floresramirez-cebriansilla-deldosso-larimer-chen-kang-etal-nestsofdividingneuroblastssustaininterneuronproductionforthedevelopinghumanbrain-2022","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["nests","dividing","neuroblasts","sustain","interneuron","production","developing","human","brain","paredes","mora","flores-ramirez","cebrian-silla","del dosso","larimer","chen","kang","gonzalez granero","garcia","chu","delgado","cotter","tang","spatazza","obernier","ferrer lozano","vento","scott","studholme","nowakowski","kriegstein","oldham","hasenstaub","garcia-verdugo","alvarez-buylla","huang"],"title":"Nests of dividing neuroblasts sustain interneuron production for the developing human brain","year":2022}