@article{Parenty2005,
	title = {Highly stable phenanthridinium frameworks as a new class of tunable {DNA} binding agents with cytotoxic properties.},
	volume = {48},
	issn = {0022-2623},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15999988},
	doi = {10.1021/jm050320z},
	abstract = {A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.},
	number = {14},
	journal = {Journal of medicinal chemistry},
	author = {Parenty, Alexis D C and Smith, Louise V and Guthrie, Kevin M and Long, De-Liang and Plumb, Jane and Brown, Robert and Cronin, Leroy},
	month = jul,
	year = {2005},
	pmid = {15999988},
	keywords = {\#nosource, Antineoplastic Agents, Antineoplastic Agents: chemical synthesis, Antineoplastic Agents: chemistry, Antineoplastic Agents: pharmacology, Antitumor, Cell Line, Crystallography, DNA, DNA: metabolism, Drug Screening Assays, Humans, Imidazoles, Imidazoles: chemical synthesis, Imidazoles: chemistry, Imidazoles: pharmacology, Intercalating Agents, Intercalating Agents: chemical synthesis, Intercalating Agents: chemistry, Intercalating Agents: pharmacology, Phenanthridines, Phenanthridines: chemical synthesis, Phenanthridines: chemistry, Phenanthridines: pharmacology, Structure-Activity Relationship, Tumor, X-Ray},
	pages = {4504--6},
}

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