Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. Park, S. L., Cheng, I., Pendergrass, S. A., Kucharska-Newton, A. M., Lim, U., Ambite, J. L., Caberto, C. P., Monroe, K. R., Schumacher, F., Hindorff, L. A., Oetjens, M. T., Wilson, S., Goodloe, R. J., Love, S., Henderson, B. E., Kolonel, L. N., Haiman, C. A., Crawford, D. C., North, K. E., Heiss, G., Ritchie, M. D., Wilkens, L. R., & Le Marchand, L. American journal of epidemiology, 178:780–790, September, 2013. ![Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Common obesity risk variants have been associated with macronutrient intake; however, these associations' generalizability across populations has not been demonstrated. We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 Population Architecture using Genomics and Epidemiology (PAGE) studies: the Multiethnic Cohort Study (1993-2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987-1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991-1994) (n = 6,347). We used linear regression, with adjustment for age, sex, and ethnicity, to estimate the associations between obesity risk genotypes and macronutrient intake. A fixed-effects meta-analysis model showed that the FTO rs8050136 A allele (n = 36,973) was positively associated with percentage of calories derived from fat (βmeta = 0.2244 (standard error, 0.0548); P = 4 × 10(-5)) and inversely associated with percentage of calories derived from carbohydrate (βmeta = -0.2796 (standard error, 0.0709); P = 8 × 10(-5)). In the Multiethnic Cohort Study, percentage of calories from fat assessed at baseline was a partial mediator of the rs8050136 effect on body mass index (weight (kg)/height (m)(2)) obtained at 10 years of follow-up (mediation of effect = 0.0823 kg/m(2), 95% confidence interval: 0.0559, 0.1128). Our data provide additional evidence that the association of FTO with obesity is partially mediated by dietary intake.
@article{ParkChengPendergrassEtAl2013,
abstract = {Common obesity risk variants have been associated with macronutrient intake; however, these associations' generalizability across populations has not been demonstrated. We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 {Population Architecture using Genomics and Epidemiology} (PAGE) studies: the Multiethnic Cohort Study (1993-2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987-1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991-1994) (n = 6,347). We used linear regression, with adjustment for age, sex, and ethnicity, to estimate the associations between obesity risk genotypes and macronutrient intake. A fixed-effects meta-analysis model showed that the FTO rs8050136 A allele (n = 36,973) was positively associated with percentage of calories derived from fat (βmeta = 0.2244 (standard error, 0.0548); P = 4 × 10(-5)) and inversely associated with percentage of calories derived from carbohydrate (βmeta = -0.2796 (standard error, 0.0709); P = 8 × 10(-5)). In the Multiethnic Cohort Study, percentage of calories from fat assessed at baseline was a partial mediator of the rs8050136 effect on body mass index (weight (kg)/height (m)(2)) obtained at 10 years of follow-up (mediation of effect = 0.0823 kg/m(2), 95% confidence interval: 0.0559, 0.1128). Our data provide additional evidence that the association of FTO with obesity is partially mediated by dietary intake.},
author = {Park, Sungshim Lani and Cheng, Iona and Pendergrass, Sarah A. and Kucharska-Newton, Anna M. and Lim, Unhee and Ambite, Jose Luis and Caberto, Christian P. and Monroe, Kristine R. and Schumacher, Fredrick and Hindorff, Lucia A. and Oetjens, Matthew T. and Wilson, Sarah and Goodloe, Robert J. and Love, Shelly-Ann and Henderson, Brian E. and Kolonel, Laurence N. and Haiman, Christopher A. and Crawford, Dana C. and North, Kari E. and Heiss, Gerardo and Ritchie, Marylyn D. and Wilkens, Lynne R. and Le Marchand, Lo{\"\i}c},
chemicals = {Dietary Fats, Proteins, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, FTO protein, human},
citation-subset = {IM},
completed = {2013-11-04},
country = {United States},
doi = {10.1093/aje/kwt028},
issn = {1476-6256},
issn-linking = {0002-9262},
issue = {5},
journal = {American journal of epidemiology},
keywords = {Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Continental Population Groups, genetics; Diet; Dietary Fats, administration & dosage; Energy Intake; Ethnic Groups, genetics; Female; Genotype; Humans; Male; Middle Aged; Obesity, ethnology, genetics; Polymorphism, Single Nucleotide; Proteins, genetics; Risk Factors; energy intake; fat mass and obesity-associated (FTO) gene; obesity; percent calories from fat; race/ethnicity},
month = sep,
nlm-id = {7910653},
owner = {NLM},
pages = {780--790},
pii = {kwt028},
pmc = {PMC3755639},
pmid = {23820787},
url = {https://pubmed.ncbi.nlm.nih.gov/23820787/},
pubmodel = {Print-Electronic},
pubstate = {ppublish},
revised = {2018-11-13},
title = {Association of the {FTO} obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the {PAGE} study.},
volume = {178},
year = {2013},
bdsk-url-1 = {https://pubmed.ncbi.nlm.nih.gov/23820787/},
bdsk-url-2 = {https://doi.org/10.1093/aje/kwt028}}
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We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 Population Architecture using Genomics and Epidemiology (PAGE) studies: the Multiethnic Cohort Study (1993-2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987-1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991-1994) (n = 6,347). We used linear regression, with adjustment for age, sex, and ethnicity, to estimate the associations between obesity risk genotypes and macronutrient intake. A fixed-effects meta-analysis model showed that the FTO rs8050136 A allele (n = 36,973) was positively associated with percentage of calories derived from fat (βmeta = 0.2244 (standard error, 0.0548); P = 4 × 10(-5)) and inversely associated with percentage of calories derived from carbohydrate (βmeta = -0.2796 (standard error, 0.0709); P = 8 × 10(-5)). In the Multiethnic Cohort Study, percentage of calories from fat assessed at baseline was a partial mediator of the rs8050136 effect on body mass index (weight (kg)/height (m)(2)) obtained at 10 years of follow-up (mediation of effect = 0.0823 kg/m(2), 95% confidence interval: 0.0559, 0.1128). 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