Morphological transitions in polymer vesicles upon bilayer swelling with small hydrophobic molecules in water. Parmenter, C., D., J., Chen, R., Cheung, D., L., & Bon, S., A., F. Soft Matter, 9(29):6890, Royal Society of Chemistry, 2013. ![Morphological transitions in polymer vesicles upon bilayer swelling with small hydrophobic molecules in water [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex We show that when unilamellar polymer vesicles dispersed in water made from a blockcopolymer, in this case poly((ethylene oxide)45-block-(methyl methacrylate)164), poly((ethylene oxide)45-block-(methyl methacrylate)170), or poly(n-butyl methacrylate)81-block-(2-(dimethylamino)ethyl methacrylate)20, are exposed to small hydrophobic molecules, here methyl methacrylate as well as n-butyl methacrylate, they can undergo morphological transitions. Upon swelling, the polymersomes lose their original simple bilayer morphology and transform into more complex coil-like and patchy colloidal structures, as investigated experimentally by cryogenic electron microscopy (cryo-EM). Dissipative particle dynamics (DPD) simulations on a model flat bilayer indeed show that transitions can occur upon bilayer swelling, which is accompanied by a change in the mechanical bilayer properties. The transition involves the formation of water pockets in the interior regions of the bilayer. Co-existence of the various morphologies in the experiments suggests an activation barrier towards morphological changes and a possibility of multiple meta-stable states. The latter indeed is supported by the existence of multiple minima in the surface tension as a function of bilayer area, as found in the simulations.
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abstract = {We show that when unilamellar polymer vesicles dispersed in water made from a blockcopolymer, in this case poly((ethylene oxide)45-block-(methyl methacrylate)164), poly((ethylene oxide)45-block-(methyl methacrylate)170), or poly(n-butyl methacrylate)81-block-(2-(dimethylamino)ethyl methacrylate)20, are exposed to small hydrophobic molecules, here methyl methacrylate as well as n-butyl methacrylate, they can undergo morphological transitions. Upon swelling, the polymersomes lose their original simple bilayer morphology and transform into more complex coil-like and patchy colloidal structures, as investigated experimentally by cryogenic electron microscopy (cryo-EM). Dissipative particle dynamics (DPD) simulations on a model flat bilayer indeed show that transitions can occur upon bilayer swelling, which is accompanied by a change in the mechanical bilayer properties. The transition involves the formation of water pockets in the interior regions of the bilayer. Co-existence of the various morphologies in the experiments suggests an activation barrier towards morphological changes and a possibility of multiple meta-stable states. The latter indeed is supported by the existence of multiple minima in the surface tension as a function of bilayer area, as found in the simulations.},
bibtype = {article},
author = {Parmenter, Christopher D. J. and Chen, Rong and Cheung, David L. and Bon, Stefan A. F.},
doi = {10.1039/c3sm50184a},
journal = {Soft Matter},
number = {29}
}
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