Diffusion of DNA molecules in gel at high electric fields. Pasciak, P., Krawczyk, M., Gudowska-Nowak, E., & Kulakowski, K. Journal of Biological Physics, 31(3-4):365-373, 2005. Paper doi abstract bibtex Problems related to the gel electrophoretic migration of polymers can be investigated by models based on a Brownian-type ratchet where a particle can undergo a net transport on a potential energy surface that is externally driven to fluctuate between several distinct states. Here we describe the method of polymer transport and separation by means of the cellular automata technique. Numerical simulations of the polymer reptation in the model system allow us to understand the band-broadening processes in the gel electrophoresis experiments. They indicate also possible ways of fine-tuning the parameters in designing desired resolution of the experiments. © Springer 2005.
@ARTICLE{Pasciak2005365,
author={Pasciak, P. and Krawczyk, M.J. and Gudowska-Nowak, E. and Kulakowski, K.},
title={Diffusion of DNA molecules in gel at high electric fields},
journal={Journal of Biological Physics},
year={2005},
volume={31},
number={3-4},
pages={365-373},
doi={10.1007/s10867-005-7287-2},
url={https://www2.scopus.com/inward/record.uri?eid=2-s2.0-28744432533&doi=10.1007%2fs10867-005-7287-2&partnerID=40&md5=dc3d74affa3150521e5cd2eb7cadcccb},
abstract={Problems related to the gel electrophoretic migration of polymers can be investigated by models based on a Brownian-type ratchet where a particle can undergo a net transport on a potential energy surface that is externally driven to fluctuate between several distinct states. Here we describe the method of polymer transport and separation by means of the cellular automata technique. Numerical simulations of the polymer reptation in the model system allow us to understand the band-broadening processes in the gel electrophoresis experiments. They indicate also possible ways of fine-tuning the parameters in designing desired resolution of the experiments. © Springer 2005.},
author_keywords={Ratchet systems; Reptation model; Transport coefficients},
keywords={polymer, automation; conference paper; diffusion; diffusion coefficient; electric field; experiment; gel; gel electrophoresis; mathematical analysis; methodology; molecule; nonhuman; parameter; priority journal; separation technique; technique; tuning curve},
document_type={Conference Paper},
source={Scopus},
}
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