Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Patel, D. J, Phan, A. T., Kuryavyi, V., Luu, K N, & Tua, A. Nucleic Acids Research, 35(22):7429–7455, January, 2007. Publisher: Oxford University Press Publisher: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. pateld@mskcc.org![Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked GGGG tetrads in monovalent cation-containing solution. The length and number of individual G-tracts and the length and sequence context of linker residues define the diverse topologies adopted by G-quadruplexes. The review highlights recent solution NMR-based G-quadruplex structures formed by the four-repeat human telomere in K+ solution and the guanine-rich strands of c-myc, c-kit and variant bcl-2 oncogenic promoters, as well as a bimolecular G-quadruplex that targets HIV-1 integrase. Such structure determinations have helped to identify unanticipated scaffolds such as interlocked G-quadruplexes, as well as novel topologies represented by double-chain-reversal and V-shaped loops, triads, mixed tetrads, adenine-mediated pentads and hexads and snap-back G-tetrad alignments. The review also highlights the recent identification of guanine-rich sequences positioned adjacent to translation start sites in 5-untranslated regions (5-UTRs) of RNA oncogenic sequences. The activity of the enzyme telomerase, which maintains telomere length, can be negatively regulated through G-quadruplex formation at telomeric ends. The review evaluates progress related to ongoing efforts to identify small molecule drugs that bind and stabilize distinct G-quadruplex scaffolds associated with telomeric and oncogenic sequences, and outlines progress towards identifying recognition principles based on several X-ray-based structures of ligandG-quadruplex complexes.
@article{Patel2007,
title = {Human telomere, oncogenic promoter and 5′-{UTR} {G}-quadruplexes: diverse higher order {DNA} and {RNA} targets for cancer therapeutics},
volume = {35},
issn = {1362-4962},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2190718&tool=pmcentrez&rendertype=abstract},
doi = {10.1093/nar/gkm711},
abstract = {Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked GGGG tetrads in monovalent cation-containing solution. The length and number of individual G-tracts and the length and sequence context of linker residues define the diverse topologies adopted by G-quadruplexes. The review highlights recent solution NMR-based G-quadruplex structures formed by the four-repeat human telomere in K+ solution and the guanine-rich strands of c-myc, c-kit and variant bcl-2 oncogenic promoters, as well as a bimolecular G-quadruplex that targets HIV-1 integrase. Such structure determinations have helped to identify unanticipated scaffolds such as interlocked G-quadruplexes, as well as novel topologies represented by double-chain-reversal and V-shaped loops, triads, mixed tetrads, adenine-mediated pentads and hexads and snap-back G-tetrad alignments. The review also highlights the recent identification of guanine-rich sequences positioned adjacent to translation start sites in 5-untranslated regions (5-UTRs) of RNA oncogenic sequences. The activity of the enzyme telomerase, which maintains telomere length, can be negatively regulated through G-quadruplex formation at telomeric ends. The review evaluates progress related to ongoing efforts to identify small molecule drugs that bind and stabilize distinct G-quadruplex scaffolds associated with telomeric and oncogenic sequences, and outlines progress towards identifying recognition principles based on several X-ray-based structures of ligandG-quadruplex complexes.},
number = {22},
journal = {Nucleic Acids Research},
author = {Patel, Dinshaw J and Phan, Anh Tuân and Kuryavyi, Vitaly and Luu, K N and Tua, Anh},
month = jan,
year = {2007},
pmid = {17913750},
note = {Publisher: Oxford University Press
Publisher: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. pateld@mskcc.org},
keywords = {\#nosource, 5' Untranslated Regions, 5' Untranslated Regions: chemistry, DNA, DNA Repeat Expansion, DNA: chemistry, DNA: drug effects, G-Quadruplexes, G-Quadruplexes: drug effects, Genetic, Humans, Neoplasms, Neoplasms: drug therapy, Oncogenes, Promoter Regions, RNA, RNA: chemistry, RNA: drug effects, Telomere, Telomere: chemistry},
pages = {7429--7455},
}
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