@article{patel_topical_2017,
	title = {Topical and low-dose intravenous tranexamic acid in cyanotic cardiac surgery.},
	volume = {25},
	issn = {1816-5370},
	abstract = {Background Coagulopathy is a major problem in surgery for cyanotic congenital heart disease. Tranexamic acid has been used both topically and systemically and plays a vital role in pediatric cardiac surgery by reducing blood loss and blood product requirement. We aimed to determine the anti-fibrinolytic effectiveness of low-dose systemic or topical tranexamic acid or a combination of both. Methods Seventy-five patients were divided in 3 groups of 25. Group A patients were given tranexamic acid 20mgkg-1 intravenously after sternotomy and 20mgkg-1 after heparin reversal. Group B patients were given tranexamic acid 50mgkg-1 in 20mL of saline intrapericardially before sternal closure, with the drain clamped for 20min. Group C patients were given tranexamic acid 20mgkg-1 intravenously after sternotomy and 50mgkg-1 intrapericardially before sternal closure. A number of clinical variables were recorded in the first 3 postoperative days. Ventilator time, intensive care unit stay, and outcome were also recorded. Results Chest tube drainage and blood product requirements were lowest in group C. Blood urea and serum creatinine levels were higher in groups A and C ( p{\textless}0.05). Intensive care unit stay and ventilator time were similar in all 3 groups. No patient died and none had a seizure or other neurological event or thromboembolic complication postoperatively. Conclusion The combination of low-dose intravenous and topical tranexamic acid reduces postoperative blood loss and blood product requirement without incurring neurological, renal or thromboembolic complications. We recommend the routine use of topical and low-dose systemic tranexamic acid in cyanotic pediatric cardiac surgery.},
	number = {2},
	journal = {Asian cardiovascular \& thoracic annals},
	author = {Patel, Jigar and Prajapati, Mrugesh and Patel, Hardik and Gandhi, Hemang and Deodhar, Shilpa and Pandya, Himani},
	year = {2017},
	note = {Patel, Jigar. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.
Prajapati, Mrugesh. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.
Patel, Hardik. 2 Department of Medical Officer, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.
Gandhi, Hemang. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.
Deodhar, Shilpa. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.
Pandya, Himani. 3 Department of Research, UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India.},
	keywords = {*Antifibrinolytic Agents/ad [Administration \& Dosage], *Blood Coagulation/de [Drug Effects], *Cardiac Surgical Procedures, *Cyanosis/et [Etiology], *Fibrinolysis/de [Drug Effects], *Heart Defects, Congenital/dt [Drug Therapy], *Postoperative Hemorrhage/pc [Prevention \& Control], *Tranexamic Acid/ad [Administration \& Dosage], Administration, Intravenous, Administration, Topical, Antifibrinolytic Agents/ae [Adverse Effects], Cardiac Surgical Procedures/ae [Adverse Effects], Chest Tubes, Child, Child, Preschool, Cyanosis/bl [Blood], Cyanosis/di [Diagnosis], Double-Blind Method, Drainage/is [Instrumentation], Heart Defects, Congenital/bl [Blood], Heart Defects, Congenital/co [Complications], Heart Defects, Congenital/di [Diagnosis], Humans, Intensive Care Units, Postoperative Hemorrhage/et [Etiology], Prospective Studies, Respiration, Artificial, Time Factors, Tranexamic Acid/ae [Adverse Effects], adolescent, female, infant, length of stay, male, treatment outcome},
	pages = {118--122}
}

{"_id":"ANxFwJsfGmTowBtYG","bibbaseid":"patel-prajapati-patel-gandhi-deodhar-pandya-topicalandlowdoseintravenoustranexamicacidincyanoticcardiacsurgery-2017","downloads":0,"creationDate":"2017-05-12T19:33:31.291Z","title":"Topical and low-dose intravenous tranexamic acid in cyanotic cardiac surgery.","author_short":["Patel, J.","Prajapati, M.","Patel, H.","Gandhi, H.","Deodhar, S.","Pandya, H."],"year":2017,"bibtype":"article","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"article","type":"article","title":"Topical and low-dose intravenous tranexamic acid in cyanotic cardiac surgery.","volume":"25","issn":"1816-5370","abstract":"Background Coagulopathy is a major problem in surgery for cyanotic congenital heart disease. Tranexamic acid has been used both topically and systemically and plays a vital role in pediatric cardiac surgery by reducing blood loss and blood product requirement. We aimed to determine the anti-fibrinolytic effectiveness of low-dose systemic or topical tranexamic acid or a combination of both. Methods Seventy-five patients were divided in 3 groups of 25. Group A patients were given tranexamic acid 20mgkg-1 intravenously after sternotomy and 20mgkg-1 after heparin reversal. Group B patients were given tranexamic acid 50mgkg-1 in 20mL of saline intrapericardially before sternal closure, with the drain clamped for 20min. Group C patients were given tranexamic acid 20mgkg-1 intravenously after sternotomy and 50mgkg-1 intrapericardially before sternal closure. A number of clinical variables were recorded in the first 3 postoperative days. Ventilator time, intensive care unit stay, and outcome were also recorded. Results Chest tube drainage and blood product requirements were lowest in group C. Blood urea and serum creatinine levels were higher in groups A and C ( p\\textless0.05). Intensive care unit stay and ventilator time were similar in all 3 groups. No patient died and none had a seizure or other neurological event or thromboembolic complication postoperatively. Conclusion The combination of low-dose intravenous and topical tranexamic acid reduces postoperative blood loss and blood product requirement without incurring neurological, renal or thromboembolic complications. We recommend the routine use of topical and low-dose systemic tranexamic acid in cyanotic pediatric cardiac surgery.","number":"2","journal":"Asian cardiovascular & thoracic annals","author":[{"propositions":[],"lastnames":["Patel"],"firstnames":["Jigar"],"suffixes":[]},{"propositions":[],"lastnames":["Prajapati"],"firstnames":["Mrugesh"],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["Hardik"],"suffixes":[]},{"propositions":[],"lastnames":["Gandhi"],"firstnames":["Hemang"],"suffixes":[]},{"propositions":[],"lastnames":["Deodhar"],"firstnames":["Shilpa"],"suffixes":[]},{"propositions":[],"lastnames":["Pandya"],"firstnames":["Himani"],"suffixes":[]}],"year":"2017","note":"Patel, Jigar. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India. Prajapati, Mrugesh. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India. Patel, Hardik. 2 Department of Medical Officer, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India. Gandhi, Hemang. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India. Deodhar, Shilpa. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India. Pandya, Himani. 3 Department of Research, UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India.","keywords":"*Antifibrinolytic Agents/ad [Administration & Dosage], *Blood Coagulation/de [Drug Effects], *Cardiac Surgical Procedures, *Cyanosis/et [Etiology], *Fibrinolysis/de [Drug Effects], *Heart Defects, Congenital/dt [Drug Therapy], *Postoperative Hemorrhage/pc [Prevention & Control], *Tranexamic Acid/ad [Administration & Dosage], Administration, Intravenous, Administration, Topical, Antifibrinolytic Agents/ae [Adverse Effects], Cardiac Surgical Procedures/ae [Adverse Effects], Chest Tubes, Child, Child, Preschool, Cyanosis/bl [Blood], Cyanosis/di [Diagnosis], Double-Blind Method, Drainage/is [Instrumentation], Heart Defects, Congenital/bl [Blood], Heart Defects, Congenital/co [Complications], Heart Defects, Congenital/di [Diagnosis], Humans, Intensive Care Units, Postoperative Hemorrhage/et [Etiology], Prospective Studies, Respiration, Artificial, Time Factors, Tranexamic Acid/ae [Adverse Effects], adolescent, female, infant, length of stay, male, treatment outcome","pages":"118--122","bibtex":"@article{patel_topical_2017,\n\ttitle = {Topical and low-dose intravenous tranexamic acid in cyanotic cardiac surgery.},\n\tvolume = {25},\n\tissn = {1816-5370},\n\tabstract = {Background Coagulopathy is a major problem in surgery for cyanotic congenital heart disease. Tranexamic acid has been used both topically and systemically and plays a vital role in pediatric cardiac surgery by reducing blood loss and blood product requirement. We aimed to determine the anti-fibrinolytic effectiveness of low-dose systemic or topical tranexamic acid or a combination of both. Methods Seventy-five patients were divided in 3 groups of 25. Group A patients were given tranexamic acid 20mgkg-1 intravenously after sternotomy and 20mgkg-1 after heparin reversal. Group B patients were given tranexamic acid 50mgkg-1 in 20mL of saline intrapericardially before sternal closure, with the drain clamped for 20min. Group C patients were given tranexamic acid 20mgkg-1 intravenously after sternotomy and 50mgkg-1 intrapericardially before sternal closure. A number of clinical variables were recorded in the first 3 postoperative days. Ventilator time, intensive care unit stay, and outcome were also recorded. Results Chest tube drainage and blood product requirements were lowest in group C. Blood urea and serum creatinine levels were higher in groups A and C ( p{\\textless}0.05). Intensive care unit stay and ventilator time were similar in all 3 groups. No patient died and none had a seizure or other neurological event or thromboembolic complication postoperatively. Conclusion The combination of low-dose intravenous and topical tranexamic acid reduces postoperative blood loss and blood product requirement without incurring neurological, renal or thromboembolic complications. We recommend the routine use of topical and low-dose systemic tranexamic acid in cyanotic pediatric cardiac surgery.},\n\tnumber = {2},\n\tjournal = {Asian cardiovascular \\& thoracic annals},\n\tauthor = {Patel, Jigar and Prajapati, Mrugesh and Patel, Hardik and Gandhi, Hemang and Deodhar, Shilpa and Pandya, Himani},\n\tyear = {2017},\n\tnote = {Patel, Jigar. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.\nPrajapati, Mrugesh. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.\nPatel, Hardik. 2 Department of Medical Officer, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.\nGandhi, Hemang. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.\nDeodhar, Shilpa. 1 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India.\nPandya, Himani. 3 Department of Research, UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India.},\n\tkeywords = {*Antifibrinolytic Agents/ad [Administration \\& Dosage], *Blood Coagulation/de [Drug Effects], *Cardiac Surgical Procedures, *Cyanosis/et [Etiology], *Fibrinolysis/de [Drug Effects], *Heart Defects, Congenital/dt [Drug Therapy], *Postoperative Hemorrhage/pc [Prevention \\& Control], *Tranexamic Acid/ad [Administration \\& Dosage], Administration, Intravenous, Administration, Topical, Antifibrinolytic Agents/ae [Adverse Effects], Cardiac Surgical Procedures/ae [Adverse Effects], Chest Tubes, Child, Child, Preschool, Cyanosis/bl [Blood], Cyanosis/di [Diagnosis], Double-Blind Method, Drainage/is [Instrumentation], Heart Defects, Congenital/bl [Blood], Heart Defects, Congenital/co [Complications], Heart Defects, Congenital/di [Diagnosis], Humans, Intensive Care Units, Postoperative Hemorrhage/et [Etiology], Prospective Studies, Respiration, Artificial, Time Factors, Tranexamic Acid/ae [Adverse Effects], adolescent, female, infant, length of stay, male, treatment outcome},\n\tpages = {118--122}\n}\n","author_short":["Patel, J.","Prajapati, M.","Patel, H.","Gandhi, H.","Deodhar, S.","Pandya, H."],"key":"patel_topical_2017","id":"patel_topical_2017","bibbaseid":"patel-prajapati-patel-gandhi-deodhar-pandya-topicalandlowdoseintravenoustranexamicacidincyanoticcardiacsurgery-2017","role":"author","urls":{},"keyword":["*Antifibrinolytic Agents/ad [Administration & Dosage]","*Blood Coagulation/de [Drug Effects]","*Cardiac Surgical Procedures","*Cyanosis/et [Etiology]","*Fibrinolysis/de [Drug Effects]","*Heart Defects","Congenital/dt [Drug Therapy]","*Postoperative Hemorrhage/pc [Prevention & Control]","*Tranexamic Acid/ad [Administration & Dosage]","Administration","Intravenous","Administration","Topical","Antifibrinolytic Agents/ae [Adverse Effects]","Cardiac Surgical Procedures/ae [Adverse Effects]","Chest Tubes","Child","Child","Preschool","Cyanosis/bl [Blood]","Cyanosis/di [Diagnosis]","Double-Blind Method","Drainage/is [Instrumentation]","Heart Defects","Congenital/bl [Blood]","Heart Defects","Congenital/co [Complications]","Heart Defects","Congenital/di [Diagnosis]","Humans","Intensive Care Units","Postoperative Hemorrhage/et [Etiology]","Prospective Studies","Respiration","Artificial","Time Factors","Tranexamic Acid/ae [Adverse Effects]","adolescent","female","infant","length of stay","male","treatment outcome"],"downloads":0,"html":""},"search_terms":["topical","low","dose","intravenous","tranexamic","acid","cyanotic","cardiac","surgery","patel","prajapati","patel","gandhi","deodhar","pandya"],"keywords":["*antifibrinolytic agents","*blood loss","*cyanosis","*heart defects","*cardiopulmonary bypass","*congenital","*surgical","*tranexamic acid","*antifibrinolytic agents/ad [administration & dosage]","*blood coagulation/de [drug effects]","*cardiac surgical procedures","*cyanosis/et [etiology]","*fibrinolysis/de [drug effects]","congenital/dt [drug therapy]","*postoperative hemorrhage/pc [prevention & control]","*tranexamic acid/ad [administration & dosage]","administration","intravenous","administration","topical","antifibrinolytic agents/ae [adverse effects]","cardiac surgical procedures/ae [adverse effects]","chest tubes","child","child","preschool","cyanosis/bl [blood]","cyanosis/di [diagnosis]","double-blind method","drainage/is [instrumentation]","heart defects","congenital/bl [blood]","heart defects","congenital/co [complications]","heart defects","congenital/di [diagnosis]","humans","intensive care units","postoperative hemorrhage/et [etiology]","prospective studies","respiration","artificial","time factors","tranexamic acid/ae [adverse effects]","adolescent","female","infant","length of stay","male","treatment outcome"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}