Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming. Pateras, I. S., Williams, C., Gianniou, D. D., Margetis, A. T., Avgeris, M., Rousakis, P., Legaki, A., Mirtschink, P., Zhang, W., Panoutsopoulou, K., Delis, A. D., Pagakis, S. N., Tang, W., Ambs, S., Warpman Berglund, U., Helleday, T., Varvarigou, A., Chatzigeorgiou, A., Nordström, A., Tsitsilonis, O. E., Trougakos, I. P., Gilthorpe, J. D., & Frisan, T. Journal of Translational Medicine, 21(1):169, March, 2023. ![Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic agents and also ameliorates CT-associated adverse effects. However, the molecular mechanism(s) by which fasting, or short-term starvation (STS), improves the efficacy of CT is poorly characterized.
@article{pateras_short_2023,
title = {Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming},
volume = {21},
issn = {1479-5876},
url = {https://doi.org/10.1186/s12967-023-03935-9},
doi = {10.1186/s12967-023-03935-9},
abstract = {Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic agents and also ameliorates CT-associated adverse effects. However, the molecular mechanism(s) by which fasting, or short-term starvation (STS), improves the efficacy of CT is poorly characterized.},
number = {1},
urldate = {2023-03-10},
journal = {Journal of Translational Medicine},
author = {Pateras, Ioannis S. and Williams, Chloe and Gianniou, Despoina D. and Margetis, Aggelos T. and Avgeris, Margaritis and Rousakis, Pantelis and Legaki, Aigli-Ioanna and Mirtschink, Peter and Zhang, Wei and Panoutsopoulou, Konstantina and Delis, Anastasios D. and Pagakis, Stamatis N. and Tang, Wei and Ambs, Stefan and Warpman Berglund, Ulrika and Helleday, Thomas and Varvarigou, Anastasia and Chatzigeorgiou, Antonios and Nordström, Anders and Tsitsilonis, Ourania E. and Trougakos, Ioannis P. and Gilthorpe, Jonathan D. and Frisan, Teresa},
month = mar,
year = {2023},
keywords = {Breast cancer, Caloric restriction, Fasting, Metabolic reprogramming, Mitochondria, Oncological treatment, Oxidative stress, Reactive oxygen species, Starvation, Triple negative breast cancer},
pages = {169},
}
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