Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with Type 1 diabetes mellitus. Paterson M.A., Smart C.E.M., Lopez P.E., Howley P., Mcelduff P., Attia J., Morbey C., & King B.R. 2017. ![Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with Type 1 diabetes mellitus [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c \textless 64 mmol/mol (8%), BMI \textless 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results: Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points (P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points (P \textless 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min (P \textless 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink (P \textless 0.001). Conclusions: Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner. Copyright © 2017 Diabetes UK.
@misc{paterson_m.a._increasing_2017,
title = {Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with {Type} 1 diabetes mellitus},
url = {http://www3.interscience.wiley.com/journal/119818374/grouphome/home.html},
abstract = {Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c {\textless} 64 mmol/mol (8\%), BMI {\textless} 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results: Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points (P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points (P {\textless} 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min (P {\textless} 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink (P {\textless} 0.001). Conclusions: Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner. Copyright © 2017 Diabetes UK.},
journal = {Diabetic Medicine},
author = {{Paterson M.A.} and {Smart C.E.M.} and {Lopez P.E.} and {Howley P.} and {Mcelduff P.} and {Attia J.} and {Morbey C.} and {King B.R.}},
year = {2017},
keywords = {*blood glucose monitoring, *insulin dependent diabetes mellitus, Child, body mass, clinical article, clinical trial, controlled clinical trial, controlled study, dose response, female, glucose, hemoglobin A1c, human, insulin, insulin treatment, lipid, lipid diet, male, postprandial state, randomized controlled trial, school child, whey}
}
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{"_id":"3vnBjPxZRmiEfLp32","bibbaseid":"patersonma-smartcem-lopezpe-howleyp-mcelduffp-attiaj-morbeyc-kingbr-increasingtheproteinquantityinamealresultsindosedependenteffectsonpostprandialglucoselevelsinindividualswithtype1diabetesmellitus-2017","downloads":0,"creationDate":"2017-05-12T20:20:58.413Z","title":"Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with Type 1 diabetes mellitus","author_short":["Paterson M.A.","Smart C.E.M.","Lopez P.E.","Howley P.","Mcelduff P.","Attia J.","Morbey C.","King B.R."],"year":2017,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with Type 1 diabetes mellitus","url":"http://www3.interscience.wiley.com/journal/119818374/grouphome/home.html","abstract":"Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c \\textless 64 mmol/mol (8%), BMI \\textless 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results: Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points (P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points (P \\textless 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min (P \\textless 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink (P \\textless 0.001). Conclusions: Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner. Copyright © 2017 Diabetes UK.","journal":"Diabetic Medicine","author":[{"firstnames":[],"propositions":[],"lastnames":["Paterson M.A."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Smart C.E.M."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Lopez P.E."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Howley P."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Mcelduff P."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Attia J."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Morbey C."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["King B.R."],"suffixes":[]}],"year":"2017","keywords":"*blood glucose monitoring, *insulin dependent diabetes mellitus, Child, body mass, clinical article, clinical trial, controlled clinical trial, controlled study, dose response, female, glucose, hemoglobin A1c, human, insulin, insulin treatment, lipid, lipid diet, male, postprandial state, randomized controlled trial, school child, whey","bibtex":"@misc{paterson_m.a._increasing_2017,\n\ttitle = {Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with {Type} 1 diabetes mellitus},\n\turl = {http://www3.interscience.wiley.com/journal/119818374/grouphome/home.html},\n\tabstract = {Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c {\\textless} 64 mmol/mol (8\\%), BMI {\\textless} 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results: Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points (P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points (P {\\textless} 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min (P {\\textless} 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink (P {\\textless} 0.001). Conclusions: Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner. Copyright © 2017 Diabetes UK.},\n\tjournal = {Diabetic Medicine},\n\tauthor = {{Paterson M.A.} and {Smart C.E.M.} and {Lopez P.E.} and {Howley P.} and {Mcelduff P.} and {Attia J.} and {Morbey C.} and {King B.R.}},\n\tyear = {2017},\n\tkeywords = {*blood glucose monitoring, *insulin dependent diabetes mellitus, Child, body mass, clinical article, clinical trial, controlled clinical trial, controlled study, dose response, female, glucose, hemoglobin A1c, human, insulin, insulin treatment, lipid, lipid diet, male, postprandial state, randomized controlled trial, school child, whey}\n}\n\n","author_short":["Paterson M.A.","Smart C.E.M.","Lopez P.E.","Howley P.","Mcelduff P.","Attia J.","Morbey C.","King B.R."],"key":"paterson_m.a._increasing_2017","id":"paterson_m.a._increasing_2017","bibbaseid":"patersonma-smartcem-lopezpe-howleyp-mcelduffp-attiaj-morbeyc-kingbr-increasingtheproteinquantityinamealresultsindosedependenteffectsonpostprandialglucoselevelsinindividualswithtype1diabetesmellitus-2017","role":"author","urls":{"Paper":"http://www3.interscience.wiley.com/journal/119818374/grouphome/home.html"},"keyword":["*blood glucose monitoring","*insulin dependent diabetes mellitus","Child","body mass","clinical article","clinical trial","controlled clinical trial","controlled study","dose response","female","glucose","hemoglobin A1c","human","insulin","insulin treatment","lipid","lipid diet","male","postprandial state","randomized controlled trial","school child","whey"],"downloads":0,"html":""},"search_terms":["increasing","protein","quantity","meal","results","dose","dependent","effects","postprandial","glucose","levels","individuals","type","diabetes","mellitus","paterson m.a.","smart c.e.m.","lopez p.e.","howley p.","mcelduff p.","attia j.","morbey c.","king b.r."],"keywords":["*blood glucose monitoring","*insulin dependent diabetes mellitus","child","body mass","clinical article","clinical trial","controlled clinical trial","controlled study","dose response","female","glucose","hemoglobin a1c","human","insulin","insulin treatment","lipid","lipid diet","male","postprandial state","randomized controlled trial","school child","whey"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}