Transcriptional dynamics and chromatin accessibility in the regulation of shade-responsive genes in Arabidopsis. Paulišić, S., Boccaccini, A., Dreos, R., Ambrosini, G., Guex, N., Benstein, R. M., Schmid, M., & Fankhauser, C. Genome Biology, 26(1):422, December, 2025.
Transcriptional dynamics and chromatin accessibility in the regulation of shade-responsive genes in Arabidopsis [link]Paper  doi  abstract   bibtex   
Open chromatin regions host DNA regulatory motifs that are accessible to transcription factors and the transcriptional machinery. In Arabidopsis, responses to light are heavily regulated at the transcriptional level. Shade, for example, can limit photosynthesis and is rapidly perceived by phytochromes as a reduction of red to far-red light ratio (LRFR). Under shade, phytochromes become inactive, enabling PHYTOCHROME INTERACTING FACTORs (PIFs), particularly PIF7, to promote genome-wide reprogramming essential for LRFR responses. An initial strong and fast regulation of shade-responsive genes is followed by attenuation of this response under prolonged shade.
@article{paulisic_transcriptional_2025,
	title = {Transcriptional dynamics and chromatin accessibility in the regulation of shade-responsive genes in {Arabidopsis}},
	volume = {26},
	issn = {1474-760X},
	url = {https://doi.org/10.1186/s13059-025-03901-2},
	doi = {10.1186/s13059-025-03901-2},
	abstract = {Open chromatin regions host DNA regulatory motifs that are accessible to transcription factors and the transcriptional machinery. In Arabidopsis, responses to light are heavily regulated at the transcriptional level. Shade, for example, can limit photosynthesis and is rapidly perceived by phytochromes as a reduction of red to far-red light ratio (LRFR). Under shade, phytochromes become inactive, enabling PHYTOCHROME INTERACTING FACTORs (PIFs), particularly PIF7, to promote genome-wide reprogramming essential for LRFR responses. An initial strong and fast regulation of shade-responsive genes is followed by attenuation of this response under prolonged shade.},
	language = {en},
	number = {1},
	urldate = {2025-12-18},
	journal = {Genome Biology},
	author = {Paulišić, Sandi and Boccaccini, Alessandra and Dreos, René and Ambrosini, Giovanna and Guex, Nicolas and Benstein, Ruben Maximilian and Schmid, Markus and Fankhauser, Christian},
	month = dec,
	year = {2025},
	keywords = {ATAC-seq, Arabidopsis, Chromatin accessibility, PIF7, Shade, Transcription},
	pages = {422},
}

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