@Article{Paulsen2000,
  author   = {O Paulsen and TJ Sejnowski},
  journal  = {Curr Opin Neurobiol},
  title    = {Natural patterns of activity and long-term synaptic plasticity.},
  year     = {2000},
  number   = {2},
  pages    = {172-9},
  volume   = {10},
  abstract = {Long-term potentiation (LTP) of synaptic transmission is traditionally
	elicited by massively synchronous, high-frequency inputs, which rarely
	occur naturally. Recent in vitro experiments have revealed that both
	LTP and long-term depression (LTD) can arise by appropriately pairing
	weak synaptic inputs with action potentials in the postsynaptic cell.
	This discovery has generated new insights into the conditions under
	which synaptic modification may occur in pyramidal neurons in vivo.
	First, it has been shown that the temporal order of the synaptic
	input and the postsynaptic spike within a narrow temporal window
	determines whether LTP or LTD is elicited, according to a temporally
	asymmetric Hebbian learning rule. Second, backpropagating action
	potentials are able to serve as a global signal for synaptic plasticity
	in a neuron compared with local associative interactions between
	synaptic inputs on dendrites. Third, a specific temporal pattern
	of activity--postsynaptic bursting--accompanies synaptic potentiation
	in adults.},
  keywords = {Action Potentials, Animals, Computer Simulation, Excitatory Postsynaptic Potentials, Hippocampus, Human, Learning, Long-Term Potentiation, Neuronal Plasticity, Rats, Support, Non-U.S. Gov't, Synaptic Transmission, 10753798},
}

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