@article{
 title = {Human gut microbes impact host serum metabolome and insulin sensitivity},
 type = {article},
 year = {2016},
 pages = {376-381},
 volume = {535},
 id = {00fa075a-2f80-3580-b77a-3bcd671ddeba},
 created = {2025-07-07T13:25:12.164Z},
 file_attached = {true},
 profile_id = {9c1a206b-6cfb-375e-a257-a4c31f5a0791},
 group_id = {89bece75-0a7e-3035-98e1-71b82260b8e8},
 last_modified = {2025-07-07T13:25:59.509Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Pedersen2016},
 private_publication = {false},
 abstract = {Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.},
 bibtype = {article},
 author = {Pedersen, Helle Krogh and Gudmundsdottir, Valborg and Nielsen, Henrik Bjørn and Hyotylainen, Tuulia and Nielsen, Trine and Jensen, Benjamin A.H. and Forslund, Kristoffer and Hildebrand, Falk and Prifti, Edi and Falony, Gwen and Le Chatelier, Emmanuelle and Levenez, Florence and Doré, Joel and Mattila, Ismo and Plichta, Damian R. and Pöhö, Päivi and Hellgren, Lars I. and Arumugam, Manimozhiyan and Sunagawa, Shinichi and Vieira-Silva, Sara and Jørgensen, Torben and Holm, Jacob Bak and Trošt, Kajetan and Kristiansen, Karsten and Brix, Susanne and Raes, Jeroen and Wang, Jun and Hansen, Torben and Bork, Peer and Brunak, Søren and Oresic, Matej and Ehrlich, S. Dusko and Pedersen, Oluf},
 doi = {10.1038/nature18646},
 journal = {Nature},
 number = {7612}
}

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Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.","bibtype":"article","author":"Pedersen, Helle Krogh and Gudmundsdottir, Valborg and Nielsen, Henrik Bjørn and Hyotylainen, Tuulia and Nielsen, Trine and Jensen, Benjamin A.H. and Forslund, Kristoffer and Hildebrand, Falk and Prifti, Edi and Falony, Gwen and Le Chatelier, Emmanuelle and Levenez, Florence and Doré, Joel and Mattila, Ismo and Plichta, Damian R. and Pöhö, Päivi and Hellgren, Lars I. and Arumugam, Manimozhiyan and Sunagawa, Shinichi and Vieira-Silva, Sara and Jørgensen, Torben and Holm, Jacob Bak and Trošt, Kajetan and Kristiansen, Karsten and Brix, Susanne and Raes, Jeroen and Wang, Jun and Hansen, Torben and Bork, Peer and Brunak, Søren and Oresic, Matej and Ehrlich, S. Dusko and Pedersen, Oluf","doi":"10.1038/nature18646","journal":"Nature","number":"7612","bibtex":"@article{\n title = {Human gut microbes impact host serum metabolome and insulin sensitivity},\n type = {article},\n year = {2016},\n pages = {376-381},\n volume = {535},\n id = {00fa075a-2f80-3580-b77a-3bcd671ddeba},\n created = {2025-07-07T13:25:12.164Z},\n file_attached = {true},\n profile_id = {9c1a206b-6cfb-375e-a257-a4c31f5a0791},\n group_id = {89bece75-0a7e-3035-98e1-71b82260b8e8},\n last_modified = {2025-07-07T13:25:59.509Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {Pedersen2016},\n private_publication = {false},\n abstract = {Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. 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