@article{pena-abaurrea_comprehensive_2011,
	title = {Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the identification of organobrominated compounds in bluefin tuna.},
	volume = {1218},
	issn = {1873-3778},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21872866},
	doi = {10.1016/j.chroma.2011.08.031},
	abstract = {This study evaluates comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (GC×GC-ToF MS) for the simultaneous analysis of several classes of organobromines (OBs), including polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), methoxylated PBDEs (MeO-PBDEs), several halogenated naturally produced compounds (HNPs) and eight novel brominated flame retardants (NBFRs), polybrominated hexahydroxanthene derivates (PBHDs), 2,4,6-tribromoanisole and a mixed halogenated compound (MHC-1), in bluefin tuna muscles. The proposed methodology maximised separation of both within and among OB families, and among these and other halogenated micropollutants detected in these samples and co-extracted matrix components. Special attention has been paid to solve co-elution problems observed during the analysis of OBs with one-dimensional GC-based techniques. Satisfactory separation among several relevant PBDEs and MeO-PBDEs has been obtained allowing their unambiguous determination in a single run. Additional studies were conducted to identify selected NBFRs and HNPs. 2,4-Dibromoanisole, a dibromophenol isomer and hexabromobenzene were identified in the investigated samples. Several new tri- and tetra-BHD derivates were also identified, indicating that these compounds could apparently exist as structured families in nature. In addition, a tetrabrominated diMeO-biphenyl and two tetrabrominated diMeO-BDEs were also tentatively identified.},
	number = {39},
	journal = {Journal of chromatography. A},
	author = {Pena-Abaurrea, Miren and Covaci, Adrian and Ramos, Lourdes},
	month = sep,
	year = {2011},
	pmid = {21872866},
	keywords = {Animals, Brominated, Brominated: analysis, Environmental Monitoring, Environmental Monitoring: methods, Female, Flame Retardants: analysis, Flame retardants, Gas Chromatography-Mass Spectrometry, Gas Chromatography-Mass Spectrometry: methods, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Hydrocarbons, Male, Muscles, Muscles: chemistry, Tuna, unsure},
	pages = {6995--7002},
}

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The proposed methodology maximised separation of both within and among OB families, and among these and other halogenated micropollutants detected in these samples and co-extracted matrix components. Special attention has been paid to solve co-elution problems observed during the analysis of OBs with one-dimensional GC-based techniques. Satisfactory separation among several relevant PBDEs and MeO-PBDEs has been obtained allowing their unambiguous determination in a single run. Additional studies were conducted to identify selected NBFRs and HNPs. 2,4-Dibromoanisole, a dibromophenol isomer and hexabromobenzene were identified in the investigated samples. Several new tri- and tetra-BHD derivates were also identified, indicating that these compounds could apparently exist as structured families in nature. In addition, a tetrabrominated diMeO-biphenyl and two tetrabrominated diMeO-BDEs were also tentatively identified.","number":"39","journal":"Journal of chromatography. A","author":[{"propositions":[],"lastnames":["Pena-Abaurrea"],"firstnames":["Miren"],"suffixes":[]},{"propositions":[],"lastnames":["Covaci"],"firstnames":["Adrian"],"suffixes":[]},{"propositions":[],"lastnames":["Ramos"],"firstnames":["Lourdes"],"suffixes":[]}],"month":"September","year":"2011","pmid":"21872866","keywords":"Animals, Brominated, Brominated: analysis, Environmental Monitoring, Environmental Monitoring: methods, Female, Flame Retardants: analysis, Flame retardants, Gas Chromatography-Mass Spectrometry, Gas Chromatography-Mass Spectrometry: methods, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Hydrocarbons, Male, Muscles, Muscles: chemistry, Tuna, unsure","pages":"6995–7002","bibtex":"@article{pena-abaurrea_comprehensive_2011,\n\ttitle = {Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the identification of organobrominated compounds in bluefin tuna.},\n\tvolume = {1218},\n\tissn = {1873-3778},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/21872866},\n\tdoi = {10.1016/j.chroma.2011.08.031},\n\tabstract = {This study evaluates comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (GC×GC-ToF MS) for the simultaneous analysis of several classes of organobromines (OBs), including polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), methoxylated PBDEs (MeO-PBDEs), several halogenated naturally produced compounds (HNPs) and eight novel brominated flame retardants (NBFRs), polybrominated hexahydroxanthene derivates (PBHDs), 2,4,6-tribromoanisole and a mixed halogenated compound (MHC-1), in bluefin tuna muscles. The proposed methodology maximised separation of both within and among OB families, and among these and other halogenated micropollutants detected in these samples and co-extracted matrix components. Special attention has been paid to solve co-elution problems observed during the analysis of OBs with one-dimensional GC-based techniques. Satisfactory separation among several relevant PBDEs and MeO-PBDEs has been obtained allowing their unambiguous determination in a single run. Additional studies were conducted to identify selected NBFRs and HNPs. 2,4-Dibromoanisole, a dibromophenol isomer and hexabromobenzene were identified in the investigated samples. Several new tri- and tetra-BHD derivates were also identified, indicating that these compounds could apparently exist as structured families in nature. In addition, a tetrabrominated diMeO-biphenyl and two tetrabrominated diMeO-BDEs were also tentatively identified.},\n\tnumber = {39},\n\tjournal = {Journal of chromatography. A},\n\tauthor = {Pena-Abaurrea, Miren and Covaci, Adrian and Ramos, Lourdes},\n\tmonth = sep,\n\tyear = {2011},\n\tpmid = {21872866},\n\tkeywords = {Animals, Brominated, Brominated: analysis, Environmental Monitoring, Environmental Monitoring: methods, Female, Flame Retardants: analysis, Flame retardants, Gas Chromatography-Mass Spectrometry, Gas Chromatography-Mass Spectrometry: methods, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Hydrocarbons, Male, Muscles, Muscles: chemistry, Tuna, unsure},\n\tpages = {6995--7002},\n}\n\n","author_short":["Pena-Abaurrea, M.","Covaci, A.","Ramos, L."],"key":"pena-abaurrea_comprehensive_2011","id":"pena-abaurrea_comprehensive_2011","bibbaseid":"penaabaurrea-covaci-ramos-comprehensivetwodimensionalgaschromatographytimeofflightmassspectrometryfortheidentificationoforganobrominatedcompoundsinbluefintuna-2011","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/21872866"},"keyword":["Animals","Brominated","Brominated: analysis","Environmental Monitoring","Environmental Monitoring: methods","Female","Flame Retardants: analysis","Flame retardants","Gas Chromatography-Mass Spectrometry","Gas Chromatography-Mass Spectrometry: methods","Halogenated Diphenyl Ethers","Halogenated Diphenyl Ethers: analysis","Hydrocarbons","Male","Muscles","Muscles: chemistry","Tuna","unsure"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/mdedeo","dataSources":["SSfxPwd7XbkRtnZ9f"],"keywords":["animals","brominated","brominated: analysis","environmental monitoring","environmental monitoring: methods","female","flame retardants: analysis","flame retardants","gas chromatography-mass spectrometry","gas chromatography-mass spectrometry: methods","halogenated diphenyl ethers","halogenated diphenyl ethers: analysis","hydrocarbons","male","muscles","muscles: chemistry","tuna","unsure"],"search_terms":["comprehensive","two","dimensional","gas","chromatography","time","flight","mass","spectrometry","identification","organobrominated","compounds","bluefin","tuna","pena-abaurrea","covaci","ramos"],"title":"Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the identification of organobrominated compounds in bluefin tuna.","year":2011}