Prostaglandin E2 receptors have differential effects on Leishmania major infection. Penke, L. R., Sudan, R., Sathishkumar, S., & Saha, B. PARASITE IMMUNOLOGY, 35(1):51-54, JAN, 2013. doi abstract bibtex Through their receptors, prostaglandins play crucial roles in various infections. Although prostaglandin E2 (PGE2) is implicated as a susceptibility factor in Leishmania infection, the relative contributions of its four receptors EP1, EP2, EP3 and EP4 to this infection remain unknown. We report that Leishmania major infection of BALB/c-derived peritoneal macrophages up-regulated EP1 and EP3 expressions but down-regulated EP2 and EP4 expressions. EP2 and EP4 agonists reduced parasite load, but EP1 and EP3 agonists increased parasite load in macrophages in vitro. Agonists of EP2 and EP4, antagonists of EP1 and EP3, or lentivirally expressed EP1-shRNA and EP3-shRNA significantly reduced parasite burden in susceptible BALB/c mice. These novel data suggest differential regulation and counteractive functions of EP receptor subsets.
@article{ ISI:000312455000006,
author = {Penke, L. R. and Sudan, R. and Sathishkumar, S. and Saha, B.},
title = {{Prostaglandin E2 receptors have differential effects on Leishmania major
infection}},
journal = {{PARASITE IMMUNOLOGY}},
year = {{2013}},
volume = {{35}},
number = {{1}},
pages = {{51-54}},
month = {{JAN}},
abstract = {{Through their receptors, prostaglandins play crucial roles in various
infections. Although prostaglandin E2 (PGE2) is implicated as a
susceptibility factor in Leishmania infection, the relative
contributions of its four receptors EP1, EP2, EP3 and EP4 to this
infection remain unknown. We report that Leishmania major infection of
BALB/c-derived peritoneal macrophages up-regulated EP1 and EP3
expressions but down-regulated EP2 and EP4 expressions. EP2 and EP4
agonists reduced parasite load, but EP1 and EP3 agonists increased
parasite load in macrophages in vitro. Agonists of EP2 and EP4,
antagonists of EP1 and EP3, or lentivirally expressed EP1-shRNA and
EP3-shRNA significantly reduced parasite burden in susceptible BALB/c
mice. These novel data suggest differential regulation and counteractive
functions of EP receptor subsets.}},
doi = {{10.1111/pim.12011}},
issn = {{0141-9838}},
unique-id = {{ISI:000312455000006}}
}
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